Abstract | BACKGROUND: METHODS: The authors studied AMPAkines ( CX546 and CX516) in rat spared nerve injury (SNI) model of neuropathic pain and Complete Freund's Adjuvant (CFA) model of inflammatory pain. They measured the effect of AMPAkines on mechanical and cold allodynia. They also evaluated their effect on depressive symptoms of pain using the forced swim test, as time of immobility on this test has been used as a measure for behavioral despair, a feature of depression. RESULTS: The authors found that CX546, compared with dimethyl sulfoxide ( DMSO) control, reduced both mechanical and sensory allodynia in SNI ( DMSO group, n = 9; CX546 group, n = 11) and CFA models (both DMSO and CX546 groups, n = 9). They found that CX546, compared with control, also reduced depressive symptoms of pain by decreasing immobility on the forced swim test in both SNI (both DMSO and CX546 groups, n = 8) and CFA models (both DMSO and CX546 groups, n = 10). Finally, they found that CX516, compared with control, also reduced mechanical and cold allodynia in the SNI model (both DMSO and CX516 groups, n = 10). CONCLUSIONS: AMPAkines alleviate pain hypersensitivity as well as depression-like behavior associated with long-lasting nerve injury and inflammatory insult.
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Authors | Alexander M Le, Michelle Lee, Chen Su, Anthony Zou, Jing Wang |
Journal | Anesthesiology
(Anesthesiology)
Vol. 121
Issue 5
Pg. 1080-90
(Nov 2014)
ISSN: 1528-1175 [Electronic] United States |
PMID | 25338127
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- 1-(1,4-benzodioxan-6-ylcarbonyl)piperidine
- 1-(quinoxalin-6-ylcarbonyl)piperidine
- Analgesics
- Anti-Inflammatory Agents, Non-Steroidal
- Antidepressive Agents
- Dioxoles
- Piperidines
- Receptors, AMPA
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Topics |
- Analgesics
(therapeutic use)
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Antidepressive Agents
(pharmacology)
- Behavior, Animal
(drug effects)
- Dioxoles
(therapeutic use)
- Inflammation
(chemically induced, drug therapy)
- Male
- Motor Activity
(drug effects)
- Neuralgia
(drug therapy)
- Pain Measurement
(drug effects)
- Piperidines
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Receptors, AMPA
(drug effects)
- Swimming
(psychology)
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