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Dimethyl Sulfoxide (DMSO)

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A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.

Also Known As:

DMSO; Dimethylsulfoxide; Sclerosol; Dimethyl Sulphoxide; Dimethylsulphinyl; Dimethylsulphoxide; Dimexide; Merckle Brand of Dimethyl Sulfoxide; Research Ind. Corp. Brand 1 of Dimethyl Sulfoxide; Research Ind. Corp. Brand 2 of Dimethyl Sulfoxide; Rheumabene; Rimso; Rimso 100; Rimso-50; Shire Brand of Dimethyl Sulfoxide; Sulfinylbis(methane); Sulfoxide, Dimethyl; Sulphoxide, Dimethyl; Methane, sulfinylbis-

Networked: 2614 relevant articles (144 outcomes, 244 trials/studies)

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Drug Context: Research Results

Experts

1.	Wang, Ping: 8 articles (01/2016 - 09/2012)
2.	Yang, Weng-Lang: 7 articles (01/2016 - 09/2012)
3.	Nicastro, Jeffrey: 6 articles (01/2016 - 09/2012)
4.	Coppa, Gene F: 6 articles (01/2016 - 09/2012)
5.	Cuzzocrea, Salvatore: 6 articles (05/2014 - 12/2003)
6.	Di Paola, Rosanna: 6 articles (05/2014 - 12/2003)
7.	Paterniti, Irene: 5 articles (05/2014 - 01/2010)
8.	Sava, Gianni: 5 articles (05/2008 - 02/2003)
9.	Kuncewitch, Michael: 4 articles (03/2015 - 01/2013)
10.	Shaw, D Graeme: 4 articles (09/2014 - 09/2010)

Related Diseases

1.	Neoplasms (Cancer) 10/01/1986 - "Recognition that diverse effects can occur depending on the method of application of DMSO may help to decipher the conflicting literature on its relation to tumorigenesis, could be of value in probing the mechanism of tumor promotion, and might signal further caution in its clinical use." 03/01/2015 - "In this study, we show that the enrichment of tumor cells in fresh or DMSO frozen BM samples with a minimum of 0.05% or 0.1% infiltration rate, respectively, by applying magnetic bead-based technique increased the DTC content to a sufficient level to allow SNP array analyses in 49 out of 69 samples. " 12/01/2013 - "In this study we report the synthesis, the X-ray crystal structure and the in vivo tumor growth suppression and nephroprotective activity of bis-dimethylsulfoxide-cis-tetrachlorodi-μ-pivalatodirhenium(III), cis-Re2[(CH3)3CCOO]2Cl4·2(CH3)2SO (I). " 11/01/2013 - "Complementary QRT-PCR studies in human HL1-1 and HepG2 cells treated with 50μM WY or DMSO for 1, 2, 4, 8, 12, 24 or 48h identified a minimal number of conserved orthologous responses (e.g., Pdk4, Adfp and Angptl4) while some genes (i.e., Bmf, a tumor suppressor) exhibited induction in human cells but repression in mice. " 05/08/1993 - "In this study, we examined the effect of DMSO on the adhesion of tumor cells to endothelial cells. "
2.	Pain (Aches) 11/01/2008 - "Two of the four DMSO trials, and both MSM trials reported significant improvement in pain outcomes in the treatment group compared to comparator treatments, however, methodological issues and concerns over optimal dosage and treatment period, were highlighted. " 04/10/1994 - "Pain of movement under loading and the mobility of the joints were significantly improved after, respectively, 3 and 7 days treatment with DMSO, as compared with placebo. " 11/25/1981 - "In the IDU group the interval before pain improved was significantly shorter than in the control DMSO group, and significantly fewer new vesicles developed at the three day follow up in the active group compared with the control group. " 01/01/2011 - "Current evidence suggests DMSO and MSM are not clinically effective in the reduction of pain in the treatment of OA. " 09/01/2012 - "Evaluate the efficacy of a topical treatment protocol with DMSO 50% to alleviate inflammatory processes in type 1 complex regional pain syndrome (CRPS) with a course of less than 1 year. "
3.	Amyloidosis 02/15/1989 - "In the case of renal amyloidosis with a creatinin-clearance of more than 10 ml/min, a therapeutic attempt should be made with 1.0 to 1.5 mg/day of colchicin or 10 g/day dimethylsulphoxid (DMSO) for at least six months. " 09/01/2012 - "Study on epidemiology of cutaneous amyloidosis in northern India and effectiveness of dimethylsulphoxide in cutaneous amyloidosis." 01/01/1997 - "In our study 10 patients with either MA or LA or biphasic amyloidosis were treated with a 50% solution of DMSO in water. " 12/01/1982 - "We conclude that a therapeutic trial with oral DMSO is warranted in all patients with secondary amyloidosis. " 09/01/2014 - "Endoscopic submucosal dissection combined with orally administered dimethyl sulfoxide for primary gastric localized amyloidosis."
4.	Body Weight (Weight, Body) 01/01/2016 - "At 4 h after CLP, different doses of C75 (1- or 5-mg/kg body weight) or vehicle (20% dimethyl sulfoxide in saline) were injected intraperitoneally. " 10/01/2015 - "Group I (control group) was given saline (1 ml/kg body weight (b.w.), 0.85% NaCl) and dimethyl sulfoxide (1 ml/kg b.w.); group II was treated with CCl4 (1 ml/kg b.w. " 07/01/2015 - "The VEH group was injected with DMSO (1 μl/g body weight). " 12/01/2014 - "Rats exposed to EB or MXC (at either the high and/or low dose), independent of exposure interval showed lower body weight, LBM, tibia and femur BMD and length, and total body BMD and BMC than DMSO control group (p ≤ 0.05). " 09/16/2013 - "At 8-10 weeks of age, female F344 rats were orally gavaged for 3 consecutive days with 4.5 and 24 μmol/kg body weight test article in 0.5 mL of 10% DMSO in water. "
5.	Ischemia 01/01/1983 - "It is further concluded from the available and theoretical evidence presented here, that clinical trials using DMSO in cerebral and extracerebral organ ischemia should be designed in order to evaluate the efficacy of this compound to other antithrombogenic therapies. " 01/01/2008 - "In addition to the control group, the study group received 0.1 mL/kg DMSO prior to ischemia. " 11/01/2004 - "The aim of this study was to investigate the effects of dimethyl sulfoxide on liver damage caused by ischemia-reperfusion after portal vein clamping. " 09/05/2015 - "Both rats and H9C2 cells were randomly divided into 6 groups as follows: S group, ischemia-reperfusion (I/R) group, DMSO group, IWP group, SP group, and SP + IWP group. " 01/01/2013 - "DMSO did not reverse the loss of post-ischemia neuronal immune-reactivity, but prevented the morphological damage of neurons, and significantly reduced astrocytic hyperactivity in the somato-sensory cortex and CA1 (p <0.001). "

Related Drugs and Biologics

1.	Dimethyl Sulfoxide (DMSO)
2.	Hydroxyl Radical
3.	Cisplatin (Platino)
4.	Propylene Glycol (1,2 Propanediol)
5.	EMLA
6.	Glycerol (Glycerine)
7.	Doxorubicin (Adriamycin)
8.	Mannitol (Osmitrol)
9.	Povidone-Iodine (Betadine)
10.	Ethanol (Ethyl Alcohol)

Related Therapies and Procedures

1.	Oral Administration
2.	Intravesical Administration
3.	Aftercare (After-Treatment)
4.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
5.	Intraperitoneal Injections