Enhanced oxidative damage to DNA, lipids, and proteins and levels of some antioxidant enzymes, cytokines, and heat shock proteins in patients infected with influenza H1N1 virus.

Abstract

Overweight and obesity is becoming widespread enough to generate an acceptable and misleading social status. By 2030, in the USA up to 86 % of adults will be overweight or obese. Some selected statistical data based on the body mass index (BMI) indicated that overweight was not associated with increased mortality, this provoked a conceivable interest. Added to this is the observation that while the prevalence of obesity is dramatically increasing, the cardiovascular mortality and life expectancy in the European Union and USA has improved. When more sensitive indicators of body adiposity and its distribution than the BMI, like the waist-thigh ratio in both sexes and the waist-hip ratio in women are projected on mortality, it becomes obvious that even overweight is associated with an increased health risk. Gaining excessive body fat is a continuous, frequently progressive process. Present obesity epidemic in childhood will manifest with deleterious consequences only in future years when adolescents reach adulthood. Prevention is thus essential even before the overweight sets in. Improved life expectancy observed in large populations despite obesity epidemic, is a favourable medical success in the management of hypertension, of serum lipid disorders and diabetes. While encouraging, when it is observed in large population, it does not take away the potential health risk of a metabolic disorder in an individual who is overweight (Fig. 7, Ref. 25).

• Authors: J-Y Lim, E Oh, Y Kim, W-W Jung, H-S Kim, J Lee, D Sul
• Journal: Acta virologica (Acta Virol) Vol. 58 Issue 3 Pg. 253-60 ( 2014) ISSN: 0001-723X [Print] Slovakia
• PMID: 25283860 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Cytokines
• Heat-Shock Proteins

Topics

• Adult
• Antioxidants (metabolism)
• Case-Control Studies
• Cytokines (genetics, metabolism)
• DNA Damage
• Female
• Heat-Shock Proteins (genetics, metabolism)
• Humans
• Influenza A Virus, H1N1 Subtype (physiology)
• Influenza, Human (complications, genetics, metabolism, virology)
• Lipid Metabolism
• Male
• Middle Aged
• Obesity (complications, genetics, metabolism)
• Oxidative Stress
• Young Adult