Abstract | OBJECTIVE: METHODS: RESULTS: No significant differences were observed in lipid peroxidation among the groups. The superoxide dismutase activity was increased (P < 0.05) in the PFC-treated group. The expressions of nuclear factor қB, inducible nitric oxide synthase, and caspase 3 were significantly lower in the PFC group than in the IR group (P < 0.05). The histologic analysis showed a reduction in lung injuries in the PFC group compared with the sham and IR groups. CONCLUSION: The use of endobronchial PFC reduces the inflammatory response, preserves the alveolar structure, and protects the lungs against the hazardous effects of ischemia-reperfusion injuries.
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Authors | Luiz Alberto Forgiarini Jr, Luiz Felipe Forgiarini, Darlan Pase da Rosa, Rodrigo Mariano, Jane Maria Ulbrich, Cristiano Feijó Andrade |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 183
Issue 2
Pg. 835-40
(Aug 2013)
ISSN: 1095-8673 [Electronic] United States |
PMID | 23434305
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Fluorocarbons
- NF-kappa B
- Nitric Oxide Synthase Type II
- Caspase 3
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Topics |
- Administration, Inhalation
- Animals
- Apoptosis
(drug effects)
- Blood Gas Analysis
- Caspase 3
(metabolism)
- Disease Models, Animal
- Fluorocarbons
(administration & dosage, pharmacology, therapeutic use)
- Hemodynamics
(drug effects, physiology)
- Lipid Peroxidation
(drug effects, physiology)
- Lung
(blood supply, metabolism, pathology)
- NF-kappa B
(metabolism)
- Nitric Oxide Synthase Type II
(metabolism)
- Rats
- Rats, Wistar
- Reperfusion Injury
(metabolism, pathology, prevention & control)
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