Abstract | OBJECTIVE: Zinc-α2-glycoprotein (ZAG) has been proposed to play a role in the pathogenesis of insulin resistance. Previous studies in humans and in rodents have produced conflicting results regarding the link between ZAG and insulin resistance. The objective of this study was to examine the relationships between ZAG and insulin resistance in cross-sectional and interventional studies. RESEARCH DESIGN AND METHODS: RESULTS: Circulating ZAG was lower in patients with IGT and newly diagnosed T2DM than in controls. Circulating ZAG correlated positively with HDL cholesterol and adiponectin, and correlated inversely with BMI, waist-to-hip ratio, body fat percentage, triglycerides, fasting blood glucose, fasting insulin, HbA1c, and homeostasis model assessment of insulin resistance (HOMA-IR). On multivariate analysis, ZAG was independently associated with BMI, HOMA-IR, and adiponectin. ZAG mRNA and protein were decreased in adipose tissue of T2DM patients. Moreover, circulating ZAG levels were lower in women with PCOS than in women with high insulin sensitivity. Liraglutide treatment for 12 weeks significantly increased circulating ZAG levels. CONCLUSIONS:
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Authors | Mengliu Yang, Rui Liu, Shu Li, Yu Luo, Yali Zhang, Lili Zhang, Dongfang Liu, Yaxu Wang, Zhengai Xiong, Guenther Boden, Shirong Chen, Ling Li, Gangyi Yang |
Journal | Diabetes care
(Diabetes Care)
Vol. 36
Issue 5
Pg. 1074-82
(May 2013)
ISSN: 1935-5548 [Electronic] United States |
PMID | 23275352
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adipokines
- Seminal Plasma Proteins
- Zn-Alpha-2-Glycoprotein
- Liraglutide
- Glucagon-Like Peptide 1
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Topics |
- Adipokines
(blood)
- Adult
- Aged
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(blood, drug therapy, metabolism)
- Female
- Glucagon-Like Peptide 1
(analogs & derivatives, therapeutic use)
- Humans
- Hyperglycemia
(blood, metabolism)
- Hyperinsulinism
(blood, metabolism)
- Insulin Resistance
(physiology)
- Liraglutide
- Male
- Middle Aged
- Polycystic Ovary Syndrome
- Seminal Plasma Proteins
(metabolism)
- Zn-Alpha-2-Glycoprotein
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