Anti-inflammatory activity of the oriental herb medicine, Arisaema cum Bile, in LPS-induced PMA-differentiated THP-1 cells.

Abstract	Arisaema cum Bile is widely used as a folk medicine in Korea. However, the systematic biological properties of Arisaema cum Bile have seldom been addressed. In this study, we evaluated the anti-inflammatory activity of Arisaema cum Bile extract on lipopolysaccharide (LPS)-induced inflammation in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages. The Arisaema cum Bile extract markedly inhibited the production of pro-inflammatory cytokines including interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, and also suppressed the mRNA and protein expressions of these cytokines. Furthermore, the Arisaema cum Bile extract also inhibited LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein and gene expressions in PMA-differentiaed THP-1 macrophages. These results suggest that Arisaema cum Bile extract may have potential for development into an effective anti-inflammatory agent, and/or as an ingredient of functional foods.
Authors	Chang-Bum Ahn, Jae-Young Je
Journal	Immunopharmacology and immunotoxicology (Immunopharmacol Immunotoxicol) Vol. 34 Issue 3 Pg. 379-84 (Jun 2012) ISSN: 1532-2513 [Electronic] England
PMID	21981079 (Publication Type: Journal Article)
Chemical References	Anti-Inflammatory Agents Carcinogens IL1B protein, human IL6 protein, human Interleukin-1beta Interleukin-6 Lipopolysaccharides Plant Extracts RNA, Messenger Tumor Necrosis Factor-alpha Cyclooxygenase 2 PTGS2 protein, human Tetradecanoylphorbol Acetate
Topics	Anti-Inflammatory Agents (chemistry, pharmacology) Arisaema (chemistry) Carcinogens (pharmacology) Cell Differentiation (drug effects) Cell Line Cyclooxygenase 2 (biosynthesis) Gene Expression Regulation (drug effects) Humans Interleukin-1beta (biosynthesis) Interleukin-6 (biosynthesis) Lipopolysaccharides (pharmacology) Medicine, Korean Traditional Plant Extracts (chemistry, pharmacology) Plants, Medicinal (chemistry) RNA, Messenger (biosynthesis) Tetradecanoylphorbol Acetate (pharmacology) Tumor Necrosis Factor-alpha (biosynthesis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!