phorbol

RN given refers to (1aR-(1a alpha,1b beta,4a beta,7a alpha,7b alpha,8 alpha,9 beta,9b beta))-isomer; synonym isophorbol refers to (4a alpha)-isomer; structure in Merck Index, 9th ed, #7143

Also Known As:

Networked: 1373 relevant articles (11 outcomes, 104 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kazanietz, Marcelo G: 6 articles (01/2019 - 10/2005)
2.	Lee, Jae-Won: 5 articles (12/2023 - 09/2019)
3.	Kim, Cheorl-Ho: 4 articles (01/2019 - 03/2005)
4.	Hussaini, Isa M: 4 articles (11/2007 - 12/2004)
5.	Kuroda, Y: 4 articles (04/2002 - 06/2000)
6.	Ahn, Kyung-Seop: 3 articles (12/2023 - 09/2019)
7.	Lee, Jae Kyoung: 3 articles (07/2023 - 09/2019)
8.	Lee, Su Ui: 3 articles (07/2023 - 09/2019)
9.	Ryu, Hyung Won: 3 articles (07/2023 - 09/2019)
10.	Han, Na-Ra: 3 articles (01/2023 - 10/2016)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2017 - "In the present study, we found that pre- or post-treatment with EYK inhibited phorbol 12-myristate 13-acetate (PMA)-induced cancer cell migration and invasion in A172 cells, but not in U373MG or T98G cells. " 01/01/1974 - "V. Studies of the metabolism of tumor promoting and non promoting phorbol derivatives in vivo and in vitro." 01/01/2015 - "As it contains phorbol derivatives, we investigated the mutagenicity and tumor-promoting activity of Tiglium seed. " 02/01/2012 - "Phorbol 12-myristate 13-acetate-activated granulocytes (CD16(low)/CD66b(++)/CD15(+)) that have a phenotype similar to MDSCs from cancer patients, effectively suppressed both proliferation and cytotoxicity of normal T cells. " 05/01/2011 - "These compounds have been previously demonstrated to inhibit phorbol 12-myristate-13-acetate (PMA) induced tumor promotion in mouse skin, but their mechanism of action has never been elucidated. "
2.	Inflammation (Inflammations) 05/01/2022 - "To study the protective effects and molecular mechanism of CK, phorbol 12-myristate 13-acetate (PMA)-induced human airway epithelial (NCI-H292) cells were used as a cellular model of airway inflammation. " 09/01/2019 - "In this study, we investigated whether 2ccPA has anti-inflammatory effect on peripheral immune function or not using inflammation-induced macrophages-like cell line, THP-1 monocytes differentiated by phorbol 12-myristate 13-acetate (PMA). " 12/01/2023 - "Phorbol 12-myristate 13-acetate (PMA, 100 nM) was used to induce inflammation in A549 airway epithelial cells. " 01/01/2022 - "The exposure of uninfected and RSV-infected HAE cultures to NETs, as produced by stimulation of neutrophils by a low dose of phorbol 12-myristate 13-acetate (PMA), did not induce or aggravate cell injury or inflammation. " 01/01/2022 - "The THP-1 cells were differentiated into macrophages under the stimulation of phorbol 12-myristate 13-acetate (PMA) and then treated with LPS to build a cellular inflammation model. "
3.	Lymphoma (Lymphomas) 05/01/2017 - "Differentiation of human lymphoma cell line U937 can be triggered by phorbol 12-myristate 13-acetate (PMA). " 08/01/2011 - "The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to phorbol 12-myristate 13-acetate (PMA). " 12/21/2001 - "U-937 cells, which represent a human monocytelike histocytic lymphoma, were differentiated into macrophages by preincubation with phorbol 12-myristate 13-acetate (PMA). " 09/25/1986 - "In contrast to this inhibition of Ca2+ mobilization, addition of 4 beta-phorbol 12-myristate 13-acetate (PMA) to murine S49 lymphoma cells stimulated Mg2+ influx severalfold without any detectable alteration of Mg2+ efflux or of Ca2+ influx or efflux. " 06/01/1984 - "Thus, the maturational arrest of this lymphoma cell line can be overcome with phorbol 12-myristate 13-acetate, indicating that translocation of the c-myc gene does not permanently block the capacity for differentiation. "
4.	Infections 10/20/2011 - "Furthermore, phorbol 12-myristate 13-acetate (PMA)-induced c-Fos level was synergistically increased by HCV infection. " 12/29/2009 - "Knockdown of N-WASP expression blocked HCMV-induced but not phorbol 12-myristate 13-acetate (PMA)-induced monocyte motility, suggesting that a switch to and/or the distinct use of a new actin nucleator controlling motility occurs during HCMV infection of monocytes. " 03/01/2002 - "Supernatants from phorbol-induced cultures transfer latent KSHV infection to uninfected cells, which can likewise be induced to undergo lytic replication by TPA treatment, and the virus can be further serially transmitted. " 01/01/1999 - "Pretreatment of MRC-5 and phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells with IFN-alpha or IFN-gamma for 24 hr prior to the infection reduced the number of infected cells and virus yield. " 08/01/1997 - "Undifferentiated U937 cells were not susceptible to herpes simplex virus type 1 (HSV-1) infection, but after differentiation with phorbol 12-myristate 13-acetate an increase in the permissivity to the virus was observed accompanied by the production of significant levels of viral particles. "
5.	Necrosis 02/01/1996 - "Rapid killing of human neutrophils by the potent activator phorbol 12-myristate 13-acetate (PMA) accompanied by changes different from typical apoptosis or necrosis." 11/01/2005 - "The compounds completely suppressed tumour necrosis factor alpha (TNF-alpha)- and phorbol 12-myristate 13-acetate (PMA)-induced HIV-1 expression in latently HIV-1-infected OM-10.1 and U1 cell lines at non-toxic concentrations. " 03/01/2001 - "Using luminol, respiratory burst activity was assayed with a BioOrbit Luminometer to detect whole blood chemiluminescence (CL) by stimulation with phorbol 1,2-myristate 1,3-acetate (PMA) in the absence or presence of tumour necrosis factor (TNF) respectively. " 01/01/2000 - "phthalimido- (LK-511, LK-413, LK-512, LK-423, LK-508), adamantyl- (LK-415, LK-517), 7-oxoaIkyl-(LK-409) desmuramylpeptides were assessed for the tumour necrosis factor (TNF) inducing activity and the ability to modulate TNF production in in vitro phorbol 12-myristate 13-acetate (PMA) & ionomycin stimulated cultures of human peripheral blood mononuclear cells. " 01/01/2000 - "phthalimido- (LK-511, LK-413, LK-512, LK-423, LK-508), adamantyl- (LK-415, LK-517), 7-oxoalkyl-(LK-409) desmuramylpeptides were assessed for the tumour necrosis factor (TNF) inducing activity and the ability to modulate TNF production in in vitro phorbol 12-myristate 13-acetate (PMA) & ionomycin stimulated cultures of human peripheral blood mononuclear cells. "

Related Drugs and Biologics

1.	Acetates (Acetic Acid Esters)
2.	Phorbol Esters
3.	RNA (Ribonucleic Acid)
4.	Messenger RNA (mRNA)
5.	Insulin (Novolin)
6.	Adenylyl Cyclases (Adenylyl Cyclase)
7.	Phorbol 12,13-Dibutyrate
8.	mezerein
9.	Chloramphenicol O-Acetyltransferase (Chloramphenicol Acetyltransferase)
10.	Insulin Receptor

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Injections
3.	Transplantation
4.	Therapeutics
5.	Microelectrodes