Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice.

Abstract

Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones/humoral factors, such as aldosterone, angiotensin, catecholamines, endothelin, oxytocin, prolactin pro-opiomelancortin, reactive oxygen species, renin, and vasopressin. Dopamine receptors are classified into D(1)-like (D(1) and D(5)) and D(2)-like (D(2), D(3), and D(4)) subtypes based on their structure and pharmacology. In recent years, mice deficient in one or more of the five dopamine receptor subtypes have been generated, leading to a better understanding of the physiological role of each of the dopamine receptor subtypes. This review summarizes the results from studies of various dopamine receptor mutant mice on the role of individual dopamine receptor subtypes and their interactions with other G protein-coupled receptors in the regulation of blood pressure.

• Authors: Chunyu Zeng, Ines Armando, Yingjin Luo, Gilbert M Eisner, Robin A Felder, Pedro A Jose
• Journal: American journal of physiology. Heart and circulatory physiology (Am J Physiol Heart Circ Physiol) Vol. 294 Issue 2 Pg. H551-69 (Feb 2008) ISSN: 0363-6135 [Print] United States
• PMID: 18083900 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Receptors, Dopamine
• Receptors, Dopamine D1
• Receptors, Dopamine D2
• Receptors, Dopamine D3
• Receptors, Dopamine D4
• Receptors, Dopamine D5
• Dopamine

Topics

• Animals
• Blood Pressure (genetics, physiology)
• Dopamine (physiology)
• Hypertension (genetics, physiopathology)
• Mice
• Mice, Knockout
• Receptors, Dopamine (genetics, physiology)
• Receptors, Dopamine D1 (genetics, physiology)
• Receptors, Dopamine D2 (genetics, physiology)
• Receptors, Dopamine D3 (genetics, physiology)
• Receptors, Dopamine D4 (genetics, physiology)
• Receptors, Dopamine D5 (genetics, physiology)