Oxytocin (Pitocin)

A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.

Also Known As:

Networked: 2685 relevant articles (126 outcomes, 382 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Carter, C Sue: 16 articles (08/2015 - 01/2007)
2.	Young, Larry J: 10 articles (02/2015 - 04/2005)
3.	Yang, Jun: 10 articles (04/2013 - 01/2006)
4.	Brown, Colin H: 9 articles (11/2015 - 11/2003)
5.	Pournajafi-Nazarloo, Hossein: 9 articles (08/2015 - 05/2009)
6.	Faghihi, Mahdieh: 9 articles (08/2015 - 12/2009)
7.	Russell, John A: 9 articles (02/2014 - 11/2003)
8.	Guastella, Adam J: 8 articles (11/2015 - 07/2009)
9.	Uvnäs-Moberg, Kerstin: 8 articles (09/2015 - 01/2002)
10.	Lawson, Elizabeth A: 8 articles (05/2015 - 11/2011)

Related Diseases

1.	Postpartum Hemorrhage 03/01/2005 - "Postpartum hemorrhage (PPH) is the single most common cause of maternal death in the world, and oxytocin is known to be effective for its prevention and treatment. " 02/01/2012 - "Higher-dose oxytocin is more effective than lower-dose regimens to prevent postpartum hemorrhage after cesarean delivery. " 02/01/2012 - "Uterotonic drugs are recommended for the prevention and treatment of postpartum hemorrhage (PPH), and oxytocin is considered the gold standard for both indications due to its established efficacy and safety. " 10/01/2003 - "Oxytocin via Uniject holds promise for safer, more convenient use of oxytocin by trained midwives attending home deliveries, thereby potentially reducing the incidence of postpartum hemorrhage." 12/01/2012 - "Training auxiliary nurses to perform AMTSL using oxytocin in this birth center setting was effective in reducing the rate of postpartum hemorrhage; however, increased use of intrapartum oxytocin may be an unintended outcome of the increased accessibility of oxytocin."
2.	Schizophrenia (Dementia Praecox) 09/01/2014 - "Patients with schizophrenia showed significant impairments in automatic and controlled social cognition compared to healthy controls, and administration of oxytocin significantly improved their controlled, but not automatic, social cognition, F(1, 58)=8.75; p=0.004. " 11/01/2015 - "The aim of this study was to determine whether a single dose of oxytocin improved higher-order and lower-order social cognition performance for patients with schizophrenia across a well-established battery of social cognition tests. " 05/01/2013 - "This is one of the first studies to demonstrate that social perception in schizophrenia can be improved by the administration of oxytocin and that patients show a greater treatment effect than controls." 02/01/2011 - "Is oxytocin a promising treatment for schizophrenia?" 07/01/2013 - "The study supported the role of add-on yoga therapy in management of schizophrenia and demonstrated an improvement in endogenous plasma oxytocin levels in schizophrenia patients receiving yoga therapy."
3.	Hemorrhage 01/01/1997 - "Methyl carprost suppository is more effective than oxytocin in controlling postpartum bleeding. " 08/01/2013 - "We conducted a PubMed search for clinical trials that utilized oxytocin for hemorrhage prophylaxis following either vaginal or cesarean delivery. " 02/01/2015 - "After she was transferred to our hospital, she had another episode of vaginal bleeding that was successfully managed with oxytocin and hemostatic. " 11/01/2014 - "Higher-dose oxytocin to prevent obstetric hemorrhage at vaginal delivery-does duration of infusion matter?" 01/01/2014 - "To determine if there was an increase in postpartum (PP) hemorrhage after decreasing the PP oxytocin dose from 40 to 30 units. "
4.	Retained Placenta 11/01/2011 - "Intra-umbilical vein oxytocin injection is clinically effective for the management of a retained placenta." 01/01/2013 - "Efficacy of intra-umbilical oxytocin in the management of retained placenta: a randomized controlled trial." 01/01/2013 - "This was a single-center randomized controlled trial incorporating 58 women with retained placenta of more than 30 min, equally distributed into two study arms of intra-umbilical injection of oxytocin (50 IU oxytocin diluted with normal saline [NS] to a total volume 30 mL) and intra-umbilical injection of NS (30 mL). " 01/09/2010 - "Umbilical vein oxytocin for the treatment of retained placenta (Release Study): a double-blind, randomised controlled trial." 10/01/2005 - "The Release Trial: a randomised controlled trial of umbilical vein oxytocin versus placebo for the treatment of retained placenta."
5.	Uterine Inertia 11/01/2011 - "There was a significant reduction in the rate of subsequent manual removal of placenta (30 vs. 67.7%, p < 0.05), incidence of uterine atony (3.3 vs. 25.8%, p < 0.05) and the need for uterotonic agents (33.3 vs. 64.5%, p < 0.05) in the oxytocin group when compared with the control group. " 10/01/2009 - "In cases in which postpartum haemorrhage was due to uterine atony, 83.1% of women underwent examination of the uterine cavity and 96.3% received oxytocin, which proved therapeutic. " 07/01/2013 - "We conducted a secondary analysis of a 3-arm double-blind randomized trial of different dose regimens of oxytocin to prevent uterine atony after vaginal delivery. " 06/01/2011 - "Recent studies suggest that the effective dose of oxytocin for prophylaxis against uterine atony during caesarean delivery is significantly lower than the 5-10 IU historically used by anaesthesiologists. " 06/01/2010 - "This study was designed to determine the effective dose (ED)(90) of oxytocin infusion for an elective Cesarean delivery (CD) to prevent uterine atony. "

Related Drugs and Biologics

1.	Misoprostol (Cytotec)
2.	Ergonovine (Ergometrine)
3.	carbetocin
4.	Dinoprostone (PGE2)
5.	Neuropeptides
6.	Methylergonovine (Methergine)
7.	Dinoprost
8.	syntometrine
9.	Prostaglandins
10.	Hormones

Related Therapies and Procedures

1.	Cesarean Section (Caesarean Section)
2.	Analgesia
3.	Blood Transfusion (Blood Transfusions)
4.	Moxibustion
5.	Uterine Balloon Tamponade