Renin

A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.

Also Known As:

Networked: 10517 relevant articles (350 outcomes, 1054 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ichihara, Atsuhiro: 45 articles (11/2015 - 02/2002)
2.	Itoh, Hiroshi: 29 articles (10/2015 - 03/2002)
3.	Danser, A H Jan: 22 articles (10/2015 - 02/2002)
4.	Nishiyama, Akira: 21 articles (04/2015 - 02/2002)
5.	Calhoun, David A: 20 articles (04/2013 - 12/2002)
6.	Mullins, John J: 19 articles (12/2014 - 05/2002)
7.	Bader, Michael: 18 articles (11/2015 - 02/2002)
8.	Stowasser, Michael: 18 articles (09/2015 - 02/2002)
9.	Luft, Friedrich C: 18 articles (03/2011 - 03/2002)
10.	Gordon, Richard D: 17 articles (09/2015 - 02/2002)

Related Diseases

1.	Hypertension (High Blood Pressure) 11/01/1985 - "Hypertension was cured dramatically and plasma renin activity was within the normal range after the operation. " 11/01/1980 - "Patients with renin-dependent hypertension had dramatic reduction in blood pressure in most instances; 90% were cured or improved. " 09/26/2014 - "Despite lower circulating renin levels and a less significant fall in blood pressure in response to RAS inhibitors in African Americans, numerous clinical trials support the efficacy of RAS inhibitors to improve clinical outcomes in this population, especially in those with hypertension and risk factors for cardiovascular and related diseases. " 12/01/1989 - "Clinical studies have proved their efficacy, safety, and good tolerability alone or in combination with other drugs in uncomplicated hypertension in which they are particularly effective in older, low renin, and possibly, black patients. " 01/01/1988 - "Clinical studies have proved their efficacy, safety, and good tolerability alone or in combination with other drugs in uncomplicated hypertension where they are particularly effective in older and low-renin and possibly black patients. "
2.	Heart Failure 02/01/1969 - "Hepatic clearance of renin in canine experimental models for low- and high-output heart failure." 04/01/2009 - "[Direct renin inhibition: a new and promising treatment principle in heart failure?]." 03/01/2010 - "Novel treatment strategy with direct renin inhibition against heart failure." 04/01/2013 - "In a hypertensive rat model that underwent experimental MI, EF, and LVEDP, key functional indices of heart failure, were improved by treatment with combination ACE and direct renin inhibition when compared with either agent used alone." 01/01/2015 - "The purpose of our study is to analyze A/G renin genetic polymorphism in heart failure patients. "
3.	Renal Artery Obstruction (Renal Artery Stenosis) 10/01/1994 - "However, the poor specificity was related to certain clinical characteristics; high baseline plasma renin activity measurements, female gender, current smoking, renal dysfunction, and bilateral renal artery stenosis were all associated with false-positive results. " 09/01/1989 - "In six of 10 patients with unilateral renal artery stenosis and in two patients with bilateral renal artery stenoses (two of 4 affected kidneys), the split renal function was improved after the therapeutic intervention, in accordance with the drop in blood pressure and the reduction of plasma renin activity. " 11/01/1999 - "The aim of this study was to determine the role of renal innervation in the prolonged stimulation of renin secretion and renin synthesis accompanying renal artery stenosis. " 04/01/1990 - "The distribution of renin-containing cells in kidneys with renal artery stenosis--an immunocytochemical study." 04/01/1989 - "All had lateralizing renal venous renin ratio (RVRR) studies, 15 had renal artery stenosis (RAS) on angiography and one had unilateral chronic parenchymal renal disease (CPRD). "
4.	Hyperaldosteronism (Conn Syndrome) 07/01/2000 - "The blood chemistry studies showed elevated levels of peripheral renin with evidence of secondary aldosteronism. " 08/01/1989 - "In the present study, the renal, hemodynamic, humoral, and vascular effects of a synthetic (WY-47663) human analogue were studied in five water-loaded (15 ml H2O/kg) patients with adenomatous primary aldosteronism, a salt-sensitive, low renin, volume-expanded syndrome. " 01/17/1989 - "The results of a peripheral renin-study were typical for secondary aldosteronism. " 09/28/1968 - "[Renin studies in idiopathic edemas with secondary hyperaldosteronism]." 01/01/1968 - "Studies on plasma renin activity in patients with primary aldosteronism."
5.	Cardiovascular Diseases (Cardiovascular Disease) 12/01/2011 - "Moreover, novel targets have been identified in RAAS, such as the (pro)renin receptor, and molecules, which counteract the classical actions of Ang II and are therefore beneficial in cardiovascular diseases. " 03/01/2011 - "The development of the first rat knockout in the renin-angiotensin system demonstrates the efficacy of the ZFN technology for creating knockout rats for cardiovascular disease on any genetic background and emphasizes the role of renin in BP regulation and kidney function even in the low-renin SS rat." 04/01/2011 - "Recent studies have revealed that (pro)renin receptor ((P)RR), a newly identified member of the renin-angiotensin system, is associated with organ damage that occurs with cardiovascular disease. " 09/01/2009 - "Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases." 11/01/2007 - "Previous studies relating plasma renin to cardiovascular disease (CVD) and mortality yielded conflicting results. "

Related Drugs and Biologics

1.	Aldosterone
2.	Angiotensins
3.	aliskiren
4.	Captopril (Capoten)
5.	Sodium
6.	Angiotensin II
7.	Norepinephrine (Noradrenaline)
8.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
9.	Spironolactone (Aldactone)
10.	Potassium

Related Therapies and Procedures

1.	Nephrectomy
2.	Adrenalectomy
3.	Transplants (Transplant)
4.	Drug Therapy (Chemotherapy)
5.	Transplantation (Transplant Recipients)