Abstract |
The aim of the study was to evaluate the effect of exogenous mouse leptin on ethanol-induced cardiac toxicity in mice. Administering ethanol (6.32 g/kg body weight p.o.) to 4-week-old healthy mice for 45 days resulted in significantly elevated plasma levels of leptin, lactate dehydrogenase (LDH), cardiac lipid hydroperoxides (LOOH) and thiobarbituric acid reactive substances ( TBARS) and significantly decreased cardiac superoxide dismutase, catalase, vitamin C, vitamin E, reduced glutathione and glutathione-dependent enzyme levels ( glutathione peroxidase and glutathione S-transferase). Subsequent to the experimental induction of toxicity (i.e., after the initial period of 30 days) exogenous leptin was administered (230 microg/kg body weight i.p.) every alternate day for 15 days along with the daily dose of ethanol. Leptin administration to ethanol-treated mice significantly elevated the levels of plasma leptin, LDH and cardiac LOOH, TBARS, whereas the activity of antioxidant enzymes and the concentrations of vitamins C and E were further decreased significantly. These findings were consistent with our histological observations, confirming that leptin enhances cardiac toxicity in ethanol-supplemented mice.
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Authors | V Balasubramaniyan, N Nalini |
Journal | Fundamental & clinical pharmacology
(Fundam Clin Pharmacol)
Vol. 21
Issue 3
Pg. 245-53
(Jun 2007)
ISSN: 0767-3981 [Print] England |
PMID | 17521293
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Central Nervous System Depressants
- Leptin
- Thiobarbituric Acid Reactive Substances
- Vitamin E
- Ethanol
- L-Lactate Dehydrogenase
- Catalase
- Glutathione Peroxidase
- Superoxide Dismutase
- Glutathione Transferase
- Glutathione
- Ascorbic Acid
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Topics |
- Animals
- Antioxidants
(metabolism)
- Ascorbic Acid
(metabolism)
- Body Weight
(drug effects)
- Catalase
(metabolism)
- Central Nervous System Depressants
(pharmacology)
- Ethanol
(pharmacology)
- Glutathione
(metabolism)
- Glutathione Peroxidase
(metabolism)
- Glutathione Transferase
(metabolism)
- Heart
(drug effects, growth & development)
- L-Lactate Dehydrogenase
(blood)
- Leptin
(blood, pharmacokinetics, pharmacology)
- Lipid Peroxidation
- Male
- Mice
- Myocardium
(metabolism, pathology)
- Organ Size
(drug effects)
- Superoxide Dismutase
(metabolism)
- Thiobarbituric Acid Reactive Substances
(metabolism)
- Vitamin E
(metabolism)
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