Vitamin E

A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.

Networked: 6481 relevant articles (588 outcomes, 1434 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Buring, Julie E: 33 articles (09/2014 - 09/2002)
2.	Neuzil, Jiri: 31 articles (06/2015 - 05/2002)
3.	Albanes, Demetrius: 27 articles (09/2014 - 01/2002)
4.	Thompson, Ian M: 25 articles (06/2015 - 01/2003)
5.	Kline, Kimberly: 23 articles (12/2012 - 04/2002)
6.	Sanders, Bob G: 23 articles (12/2012 - 04/2002)
7.	Klein, Eric A: 21 articles (01/2015 - 01/2003)
8.	Traber, Maret G: 20 articles (03/2014 - 08/2003)
9.	Gaziano, J Michael: 19 articles (01/2015 - 08/2003)
10.	Manson, JoAnn E: 17 articles (09/2014 - 09/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2002 - "Thus vitamin E appears to be protective against genotoxicity by scavenging reactive species, but also its ability to affect the distribution of neutrophils within tumors may be important." 03/01/1992 - "The protection against genetic toxic effects may be an important part of the cancer-protective effects of vitamin E." 06/01/2013 - "Taken together, these data suggest that the use of vitamin E or its analogue as a dietary supplement may be beneficial for the treatment of cancer." 02/01/2003 - "Whether vitamin E supplementation might be effective in reducing AOM-induced colon tumors is unclear." 01/01/2003 - "A majority of studies investigating the protective effects of certain types of vitamin E in animal models of mammary cancer prevention conclude that there is little or no effect. "
2.	Atherosclerosis 08/15/1998 - "Our economic evaluation indicates that vitamin E therapy in patients with angiographically proven atherosclerosis is cost-effective in the Australian and US settings." 02/04/2003 - "In contrast, vitamin E-treated animals showed a significant reduction in progression of atherosclerosis. " 02/01/1995 - "We suggest that supplementation with low-dose vitamin E would be beneficial for ameliorating atherosclerosis." 01/01/2004 - "These interactions promise to reveal the biological properties of vitamin E and allow designing better strategies for the protection against atherosclerosis progression." 09/01/2000 - "Vitamin E (VE) is thought to be effective in preventing atherosclerosis. "
3.	Prostatic Neoplasms (Prostate Cancer) 06/01/2003 - "Increased intake of vitamin E has been suggested to be protective against prostate cancer in men, but the effects of vitamin E on prostate growth and function remain poorly defined. " 09/01/2015 - "Controversies remain over the safety and efficacy of vitamin E (i.e., α-tocopherol) supplementation use for the prevention of prostate cancer (CaP); however, associations of different tocopherol forms and CaP aggressiveness have yet to be examined. " 11/05/2014 - "The present study identified δ-T as a better form of vitamin E than α-T for future clinical studies of prostate cancer prevention. " 11/05/2014 - "In the present study, the effects of δ-tocopherol (δ-T) on growth and apoptosis of human prostate cancer cells were determined and compared with that of α-tocopherol (α-T), a commonly used form of vitamin E. " 09/01/2014 - "Recent posttrial analysis of a completed randomized trial found an increased risk of prostate cancer among healthy men taking high-dose vitamin E supplements. "
4.	Cardiovascular Diseases (Cardiovascular Disease) 12/01/1995 - "All three large epidemiologic cohort studies of vitamin E noted that high-level vitamin E intake or supplementation was associated with a significant reduction in cardiovascular disease (RRR range, 31% to 65%), as measured by various fatal and nonfatal cardiovascular end points. " 11/01/2005 - "Secondary prevention requires more adequate clinical trials with selected populations to examine protective effects of vitamin E in cardiovascular disease. " 11/01/1999 - "Data from the 1970s first suggested that vitamin E may be effective in decreasing mortality from cardiovascular disease. " 11/01/1999 - "Even though the efficacy of vitamin E in the management of cardiovascular disease has been shown, the potential role of vitamin E in the treatment of cerebrovascular disease remains essentially unknown. " 05/01/2010 - "Clinical studies at large have not demonstrated a benefit of vitamin E in the primary and secondary prevention of cardiovascular disease. "
5.	Alzheimer Disease (Alzheimer's Disease) 07/01/2002 - "Alzheimer's Disease Assessment Scale-Cognition and Wechsler Adult Intelligence Scale scores improved during the same period, and the difference between Vitamin E and DPZ treated patients was highly significant for P3 (analysis of variance) and for P3-Alzheimer's Diseases Assessment Scale-Cognition (analysis of covariance) with p < 0.001 for pooled groups of patients with AD and Group II (DPZ) versus Group II (Vitamin E). " 01/01/2009 - "There is controversy as to whether vitamin E is beneficial in Alzheimer's disease (AD). " 05/01/1999 - "In your article on Alzheimer's disease (March, 1999), you mention "high doses of vitamin E" as helpful in slowing the progression of the condition. " 01/01/2009 - "Vitamin E at a dose of 2,000 IU per day has been shown to delay Alzheimer's disease (AD) progression, but recent studies have questioned the safety of this dose level and the overall efficacy of vitamin E in AD treatment. " 01/01/2003 - "However, vitamin E was only marginally effective in clinical trials in Alzheimer's disease. "

Related Drugs and Biologics

1.	Selenium
2.	Ascorbic Acid (Vitamin C)
3.	Antioxidants
4.	alpha-Tocopherol
5.	beta Carotene (Betacarotene)
6.	Vitamins
7.	Carotenoids (Carotene)
8.	Glutathione (Reduced Glutathione)
9.	Tocopherols
10.	Zinc

Related Therapies and Procedures

1.	Chemoprevention
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration
4.	Renal Dialysis (Hemodialysis)
5.	Ligation