Abstract | BACKGROUND: METHODS: RESULTS: The present results showed that amygdalin suppressed the prostaglandin E(2) synthesis and the nitric oxide production by inhibiting the LPS-stimulated mRNA expressions of COX-2 and iNOS in the mouse BV2 cells. CONCLUSION: These results show that amygdalin exerts anti-inflammatory and analgesic effects and it dose so probably by suppressing the mRNA expressions of COX-2 and iNOS.
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Authors | Hye-Young Yang, Hyun-Kyung Chang, Jin-Woo Lee, Young-Sick Kim, Hong Kim, Myoung-Hwa Lee, Mal-Soon Shin, Dae-Hyun Ham, Hun-Kuk Park, Hyejung Lee, Chang-Ju Kim |
Journal | Neurological research
(Neurol Res)
Vol. 29 Suppl 1
Pg. S59-64
( 2007)
ISSN: 0161-6412 [Print] England |
PMID | 17359643
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Lipopolysaccharides
- RNA, Messenger
- Tetrazolium Salts
- Thiazoles
- Amygdalin
- Nitric Oxide Synthase Type II
- Cyclooxygenase 2
- thiazolyl blue
- Dinoprostone
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Topics |
- Amygdalin
(pharmacology)
- Animals
- Cell Line
- Cyclooxygenase 2
(metabolism)
- Dinoprostone
(metabolism)
- Drug Interactions
- Gene Expression Regulation
(drug effects)
- Lipopolysaccharides
(pharmacology)
- Mice
- Microglia
(drug effects)
- Nitric Oxide Synthase Type II
(metabolism)
- RNA, Messenger
(biosynthesis)
- Reverse Transcriptase Polymerase Chain Reaction
(methods)
- Tetrazolium Salts
- Thiazoles
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