Matrilin Proteins

PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.

Also Known As:

Cartilage Matrix Glycoprotein; Cartilage Matrix Protein; Cartilage Matrix Proteins; MATN1 Protein; MATN2 Protein; MATN3 Protein; MATN4 Protein; Matrilin 1; Matrilin 2; Matrilin 3; Matrilin 4; Matrilin-1; Matrilin-2; Matrilin-3; Matrilin-4; Matrilins; Glycoprotein, Cartilage Matrix; Matrix Glycoprotein, Cartilage; Matrix Protein, Cartilage; Matrix Proteins, Cartilage; Protein, Cartilage Matrix; Protein, MATN1; Protein, MATN2; Protein, MATN3; Protein, MATN4; Proteins, Cartilage Matrix; Proteins, Matrilin

Networked: 134 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Scleroproteins: 74
    - Extracellular Matrix Proteins: 3148
      - Matrilin Proteins: 134
        human MATN1 protein
        human MATN2 protein
        human MATN3 protein
        human MATN4 protein
        mouse Matn1 protein
        mouse Matn2 protein
        mouse Matn3 protein
        mouse Matn4 protein
        rat Matn2 protein

Experts

1.	Briggs, Michael D: 11 articles (01/2019 - 05/2002)
2.	Wagener, Raimund: 11 articles (10/2018 - 02/2004)
3.	Paulsson, Mats: 9 articles (04/2015 - 02/2004)
4.	Boot-Handford, Raymond P: 6 articles (01/2019 - 07/2007)
5.	Zaucke, Frank: 6 articles (10/2018 - 07/2007)
6.	Chen, Qian: 6 articles (01/2018 - 08/2006)
7.	Wagener, R: 4 articles (01/2021 - 02/2000)
8.	Deák, Ferenc: 4 articles (06/2015 - 03/2008)
9.	Kiss, Ibolya: 4 articles (06/2015 - 03/2008)
10.	Thornton, David J: 4 articles (05/2012 - 07/2007)

Related Diseases

1.	Intervertebral Disc Degeneration 01/01/2021 - "USC-exos may represent a potentially effective agent for alleviating intervertebral disc degeneration by promoting NPC proliferation and ECM synthesis by transferring the MATN3 protein." 01/01/2021 - "USC-exos were found to be rich in MATN3 protein, and exosomal MATN3 was required for USC-exos-induced promotion of NPC proliferation and ECM synthesis, as well as alleviation of intervertebral disc degeneration in IVD rats. " 08/01/2006 - "Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand." 01/01/2021 - "The protein differences between normal and degenerative intervertebral discs were mined, and the temporal and spatial variations in matrilin-3 (MATN3) content were determined by WB and IF in the intervertebral disc tissues. " 03/01/2011 - "In contrast, a mutation in an EGF domain of matrilin-3 that is associated with hand osteoarthritis and disc degeneration does not interfere with secretion but instead with extracellular assembly of matrix structures. "
2.	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 08/29/2022 - "We quantified galactosaminoglycans (GAAGs), oligomeric cartilage matrix protein (COMP), and human cartilage glycoprotein 39 (YKL-40) in blood obtained from juvenile idiopathic arthritis (JIA) before and during 2-year treatment with etanercept (ETA), as potential biomarkers of cartilage extracellular matrix (ECM) dysfunction and indicators of efficacy of biologic therapy. "
3.	Scoliosis 01/01/2014 - "Several previous studies have evaluated the association between rs1149048 polymorphism in the matrilin-1 gene (MATN1) and the risk of adolescent idiopathic scoliosis (AIS). " 12/18/2006 - "The objective of this study was to assess a linkage disequilibrium between the matrilin-1 (MATN1) gene and the idiopathic scoliosis (IS). " 05/01/2012 - "Associations between matrilin-1 gene polymorphisms and adolescent idiopathic scoliosis curve patterns in a Korean population." 11/15/2009 - "To investigate the association between matrilin-1 gene polymorphism and bracing effectiveness in adolescent idiopathic scoliosis girls. " 11/15/2009 - "[Association between matrilin-1 gene polymorphism and bracing effectiveness in adolescent idiopathic scoliosis girls]."
4.	Osteoarthritis 12/31/2022 - " are many biological elements of the discussed disorder and they concern: the state of articular cartilage structure, matrix structure, matrix biophysical elements, molecular sponge mechanism, chondrocytes, cartilage nutrition and the severity of osteoarthritis (OA).The improvement of the conditions of the biological elements of damaged articular cartilage is considered fundamental and concerns the positive impact on numerous cartilage matrix proteins by chondroprotection. " 01/01/2021 - "The mouse matrilin-3 T298M mutation causes a predisposition for post-traumatic osteoarthritis and the corresponding knock-in mouse line therefore represents a valid model for investigating the pathogenic mechanisms involved in osteoarthritis development." 01/01/2021 - "The effect of transgenic matrilin-3 was also studied after surgically induced osteoarthritis. " 01/01/2021 - "The human matrilin-3 T303M (in mouse T298M) mutation has been proposed to predispose for osteoarthritis, but due to the lack of an appropriate animal model this hypothesis could not be tested. " 01/01/2021 - "The Matrilin-3 T298M mutation predisposes for post-traumatic osteoarthritis in a knock-in mouse model."
5.	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia) 08/21/2014 - "Studies have shown that mutations in the matrilin-3 gene (MATN3) are associated with multiple epiphyseal dysplasia (MED) and spondyloepimetaphyseal dysplasia (SEMD). " 05/01/2023 - "Multiple epiphyseal dysplasia type 5, which is usually an autosomal dominant disease (Ballhausen et al., 2003 [1]) characterized by normal height; it is seen due to heterozygous mutation of matrilin-3 gene (MATN3) at 2p24.1 location. " 04/07/2020 - "A novel p.A191D matrilin-3 variant in a Vietnamese family with multiple epiphyseal dysplasia: a case report." 12/20/2013 - "Mutant matrilin-3 (V194D) forms non-native disulphide bonded aggregates in the rER of chondrocytes from cell and mouse models of multiple epiphyseal dysplasia (MED). " 05/01/2012 - "Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation."

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Chitinase-3-Like Protein 1
3.	Etanercept (Enbrel)
4.	Aggrecans (Aggrecan)
5.	Tenascin
6.	inhibin A
7.	Proteins (Proteins, Gene)
8.	Collagen
9.	Matrilin Proteins
10.	Cartilage Oligomeric Matrix Protein

Related Therapies and Procedures

1.	Biological Therapy
2.	Corneal Transplantation (Keratoplasty)