Tenascin

Hexameric extracellular matrix glycoprotein transiently expressed in many developing organs and often re-expressed in tumors. It is present in the central and peripheral nervous systems as well as in smooth muscle and tendons. (From Kreis & Vale, Guidebook to the Extracellular Matrix and Adhesion Proteins, 1993, p93)

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Networked: 1210 relevant articles (14 outcomes, 172 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yoshida, Toshimichi: 50 articles (01/2016 - 04/2002)
2.	Imanaka-Yoshida, Kyoko: 45 articles (01/2016 - 07/2002)
3.	Chiquet-Ehrismann, Ruth: 23 articles (10/2015 - 01/2003)
4.	Neri, Dario: 20 articles (04/2015 - 06/2005)
5.	Orend, Gertraud: 18 articles (11/2015 - 06/2003)
6.	Hiroe, Michiaki: 17 articles (10/2015 - 07/2002)
7.	Taki, Waro: 14 articles (01/2015 - 10/2005)
8.	Suzuki, Hidenori: 13 articles (01/2016 - 05/2008)
9.	Berndt, Alexander: 13 articles (01/2015 - 07/2004)
10.	Franz, Marcus: 11 articles (01/2015 - 07/2006)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2015 - "PET imaging studies for the evaluation of tumor uptake and pharmacokinetics of tenascin-C aptamer were performed in comparison to a nonspecific scrambled aptamer (Sc aptamer). " 01/01/2012 - "The present study extends the tumor biomarker potential of tenascin-W to a broad range of solid tumors and shows its accessibility from the blood stream for potential therapeutic strategies." 01/01/2012 - "The present study was undertaken to determine whether tenascin-W could serve as a cancer-specific extracellular matrix protein in a broad range of solid tumors. " 01/01/2012 - "Furthermore, we discuss studies describing tenascin-C as an important component of stem cell niches and present examples reporting its role in cancer therapy resistance." 04/01/2011 - "The present study thus identified SMOC1 as a new cancer-associated protein capable of interacting with tenascin-C in vitro."
2.	Glioma (Gliomas) 03/01/2013 - "In the current study, we show that miR-107 is down-regulated in glioma tissues and cell lines, and its overexpression leads to inhibition of the migratory and invasive ability of glioma cells via direct targeting of Notch2, which is known to transactivate Tenascin-C and Cox-2. " 06/01/2005 - "Dosimetry and radiographic analysis of 131I-labeled anti-tenascin 81C6 murine monoclonal antibody in newly diagnosed patients with malignant gliomas: a phase II study." 03/01/1989 - "Detailed studies on the mechanism of the tenascin-promoted cell attachment were carried out with the human glioma cell line U251MG. " 08/01/2015 - "Tenascin-C (TNC), an extracellular matrix protein overexpressed in malignant gliomas, stimulates invasion of conventional glioma cell lines (U251, U87). " 08/01/2015 - "Does Tenascin have Clinical Implications in Pathological Grade of Glioma Patients?: A Systematic Meta-Analysis."
3.	Necrosis 01/01/1991 - "In the CCl4-acutely-damaged liver a strong tenascin staining is detected in cells located among the mononuclear cells of the inflammatory infiltrates in the areas of necrosis and in cells of the sinusoids. " 07/01/1990 - "Most striking, however, was the preferential accumulation of tenascin at connective tissue-parenchymal interfaces between proliferating ductules and in areas of piecemeal necrosis. " 01/01/1996 - "In this study, the expression of tenascin in the renal interstitium was immunohistochemically evaluated in 208 renal specimens during normal kidney (23 cases), acute tubular necrosis (8), acute tubulointerstitial nephritis (8), chronic primary tubulointerstitial nephritis (30), tubulointerstitial nephritis secondary to glomerular diseases of mild (46) and severe (55) degree, ischemic damage (24), and rejection (14). " 04/01/2006 - "Circulating level of large splice variants of tenascin-C is a marker of piecemeal necrosis activity in patients with chronic hepatitis C." 01/01/1997 - "We did not find a statistically significant correlation between tenascin expression, elastosis and prognostic factors such as size of the tumour, lymph node metastasis, tumour necrosis and age. "
4.	Myocarditis (Carditis) 07/01/2009 - "The ratio of tenascin C-positive area to the whole myocardium in the active and borderline myocarditis groups was significantly greater than that in the noninflammatory group. " 12/01/2014 - "Tenascin-C aggravates autoimmune myocarditis via dendritic cell activation and Th17 cell differentiation." 12/01/2013 - "Serum tenascin-C: a novel biomarker for diagnosis and predicting prognosis of rheumatic carditis?" 05/31/2012 - "A case of fulminant myocarditis ultimately diagnosed by tenascin C staining." 03/01/2005 - "Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis."
5.	Spinal Cord Injuries (Spinal Cord Injury) 05/30/2012 - "Mice deficient in the recognition molecules, close homolog of L1 (CHL1) and tenascin-C, show improved and reduced functional recovery, respectively, after spinal cord injury compared with wild-type littermates. " 06/02/2011 - "Thus, our current study addresses the question as to which of these features prevails in vivo: whether tenascin-C reduces or enhances axonal regrowth after injury in a well accepted vertebrate model of spinal cord injury. " 06/02/2011 - "In the current study, the extracellular matrix glycoprotein tenascin-C was studied in the zebrafish spinal cord injury model to assess the often disparate functions of this multidomain molecule under in vivo conditions. " 06/02/2011 - "The extracellular matrix glycoprotein tenascin-C promotes locomotor recovery after spinal cord injury in adult zebrafish." 02/01/2005 - "Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis."

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4.	Extracellular Matrix Proteins
5.	Transforming Growth Factor beta (TGF-beta)
6.	Radioisotopes (Radionuclides)
7.	Biotin (Vitamin H)
8.	Avidin
9.	APT
10.	Fibronectins (Fibronectin)

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