Aurora Kinase C

Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. It is found primarily in GERM CELLS in the TESTIS, and may mediate CHROMOSOME SEGREGATION during SPERMATOGENESIS.

Also Known As:

Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ray, Pierre F: 3 articles (05/2022 - 04/2009)
2.	Arnoult, Christophe: 2 articles (05/2022 - 01/2015)
3.	Coutton, Charles: 2 articles (05/2022 - 01/2015)
4.	Schindler, Karen: 2 articles (01/2016 - 01/2015)
5.	Martinez, Delphine: 2 articles (01/2015 - 04/2009)
6.	Zoghmar, Abdelali: 2 articles (01/2015 - 04/2009)
7.	Cazin, Caroline: 1 article (05/2022)
8.	Kherraf, Zine-Eddine: 1 article (05/2022)
9.	Lestrade, Florence: 1 article (05/2022)
10.	Muronova, Jana: 1 article (05/2022)

Related Diseases

1.	Polyploidy 04/01/2009 - "In a previous study, we demonstrated that a homozygous mutation (c.144delC) in the Aurora Kinase C (AURKC) gene led to the production of large-headed polyploid multi-flagellar spermatozoa, a primary infertility phenotype mainly observed in North Africans. "
2.	Infertility (Sterility) 04/01/2009 - "In a previous study, we demonstrated that a homozygous mutation (c.144delC) in the Aurora Kinase C (AURKC) gene led to the production of large-headed polyploid multi-flagellar spermatozoa, a primary infertility phenotype mainly observed in North Africans. "
3.	Neoplasms (Cancer) 01/01/2015 - "Functions of Aurora kinase C in meiosis and cancer." 03/26/2012 - "As Aurora kinase C is rarely expressed in normal somatic cells and has been found over expressed in many cancer lines. " 10/12/2004 - "In addition, given the important role of Aurora kinases in cancer, evolutionary analysis and comparisons of ATP-binding domains suggest a rationale for designing dual action anti-tumor drugs that inhibit both Aurora-B and Aurora-C kinases." 09/01/2015 - "In this context, we investigated the expression of two known cancer testis genes, Aurora kinase C (AURKC) and testis expressed 101 (TEX101), and one new candidate, deleted in azoospermia 1 (DAZ1), in six breast cancer cell lines including two ductal carcinomas, T47D and BT-474, and four adenocarcinomas, MDA-MB-231, MDA-MB-468, MCF7, and SKBR3 as well as 50 breast cancer tumors in comparison to normal mammary epithelial cells using quantitative real-time reverse transcription PCR (RT-PCR). "
4.	Teratozoospermia 12/01/2017 - "To investigate the association of a very common mutation of c.144delC in the aurora kinase C (AURKC) gene with idiopathic teratozoospermia in Chinese infertile men in Sichuan. " 01/01/2015 - "Analyses of aurora kinase C (AURKC) and DPY19L2 are now recommended for patients presenting macrozoospermia and globozoospermia, respectively, two rare forms of teratozoospermia particularly frequent among North African men. " 06/01/2011 - "[Confirmation of the high prevalence in Morocco of the homozygous mutation c.144delC in the aurora kinase C gene (AURKC) in the teratozoospermia with large-headed spermatozoa]."
5.	Azoospermia 05/01/2022 - "A precise genetic diagnosis is obtained for a minority of patients and only for the most severe defects like azoospermia or macrozoospermia which is very often due to defects in the aurora kinase C (AURKC gene. " 09/01/2015 - "In this context, we investigated the expression of two known cancer testis genes, Aurora kinase C (AURKC) and testis expressed 101 (TEX101), and one new candidate, deleted in azoospermia 1 (DAZ1), in six breast cancer cell lines including two ductal carcinomas, T47D and BT-474, and four adenocarcinomas, MDA-MB-231, MDA-MB-468, MCF7, and SKBR3 as well as 50 breast cancer tumors in comparison to normal mammary epithelial cells using quantitative real-time reverse transcription PCR (RT-PCR). "

Related Drugs and Biologics

1.	Aurora Kinases
2.	Aurora Kinase B
3.	CCAAT-Enhancer-Binding Protein-delta
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
5.	NF-kappa B (NF-kB)
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Proteins (Proteins, Gene)
8.	Ligands
9.	Fibroblast Growth Factors (Fibroblast Growth Factor)
10.	Adenosine Triphosphate (ATP)