Fibroblast Growth Factors (Fibroblast Growth Factor)

A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.

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Networked: 1481 relevant articles (15 outcomes, 126 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tran, Nhan L: 11 articles (08/2014 - 02/2005)
2.	Winkles, Jeffrey A: 10 articles (01/2014 - 02/2005)
3.	Fukumoto, Seiji: 10 articles (01/2012 - 02/2004)
4.	Wellstein, Anton: 10 articles (10/2008 - 04/2003)
5.	Ezzat, Shereen: 9 articles (04/2014 - 09/2003)
6.	Ittmann, Michael: 9 articles (04/2013 - 09/2003)
7.	Cuevas, P: 9 articles (03/2006 - 01/2000)
8.	Asa, Sylvia L: 8 articles (11/2012 - 09/2003)
9.	Cuevas, Pedro: 8 articles (01/2012 - 06/2003)
10.	Presta, Marco: 7 articles (08/2015 - 02/2002)

Related Diseases

1.	Wounds and Injuries (Trauma) 05/01/2015 - "Fibroblast growth factors (FGFs) belong to the FGF superfamily with diverse biological functions, including proliferation, cellular differentiation, wound repair, angiogenesis and tumorigenesis. " 01/01/2015 - "This computational approach allowed the analysis of cell migration at the front of the wound and a reliable identification and quantification of the impaired polarization and migration of keratinocytes from mice lacking fibroblast growth factors 1 and 2--an established model of impaired healing. " 12/01/2011 - "The authors have previously demonstrated that normal mice lacking fibroblast growth factor (FGF)-7 can heal cutaneous wounds normally, likely as a result of various compensatory mechanisms. " 05/10/2001 - "[Expression of fibroblast growth factor and c-fos proto-oncogene in burned wound in rats and their influence on wound healing]." 01/01/1999 - "Fibroblast growth factors (FGFs) have mitogenic activity toward a wide variety of cells of mesenchymal, neuronal, and epithelial origin and regulate events in normal embryonic development, angiogenesis, wound repair, and neoplasia. "
2.	Coronary Artery Disease (Coronary Atherosclerosis) 01/01/2013 - "Serum levels of fibroblast growth factor 19 are inversely associated with coronary artery disease in chinese individuals." 06/01/2004 - "Clinical use of intracoronary gene transfer of fibroblast growth factor for coronary artery disease." 05/01/2015 - "The aim of this study was to evaluate the association of plasma fibroblast growth factor (FGF)-21 with angiographically significant coronary artery disease (CAD) in patients with type 2 diabetes mellitus. " 06/01/2012 - "Fibroblast growth factors (FGFs) and their receptors (FGFRs) play crucial roles in vascular smooth muscle cell proliferation and atherosclerosis and, therefore, may potentially affect the development of coronary artery disease (CAD). " 05/01/2000 - "Fibroblast growth factor, in addition to operative myocardial revascularization, may be the appropriate treatment for patients with peripheral stenosis or diffuse coronary arteriosclerosis. "
3.	Obesity 07/01/2015 - "Serum concentrations of the hepatokine fibroblast growth factor (FGF) 21 are elevated in obesity, type-2 diabetes, and the metabolic syndrome. " 01/01/2013 - "Fibroblast growth factor (FGF)-19, an endocrine FGF protein mainly produced by the ileum, stimulates metabolic activity and alleviates obesity. " 08/01/2013 - "The objectives of the study were as follows: 1) to determine circulating sTWEAK in severe obesity and after bariatric surgery; 2) to study m/sTWEAK and its receptor fibroblast growth factor-inducible 14 (Fn14) protein expression in sc adipose tissue (SAT) of severely obese subjects, in SAT stromal vascular fraction (SVF), and isolated adipocytes and in human monocyte-derived macrophages; and 3) to explore, on human adipocytes, the sTWEAK effect on TNFα proinflammatory activity. " 01/01/2011 - "The aim of our study was to measure serum concentrations of fibroblast growth factor 19 (FGF-19) in patients with obesity (OB), obesity and type 2 diabetes mellitus (T2DM) and healthy subjects (C) at baseline and after selected interventions. " 01/01/2015 - "Fibroblast growth factor (FGF)-21, and possibly FGF19, protect against type 2 diabetes mellitus (T2DM) and obesity in rodents. "
4.	Inflammation 11/01/2014 - "Moreover, administration of a bile acid-sequestering agent suppressed ileal fibroblast growth factor 15 expression, leading to increased iASBT expression to restore bile filling in the liver and biliary tree, which ameliorates steatosis and inflammation in the liver. " 10/01/2015 - "The interaction between TNF-like weak inducer of apoptosis (TWEAK, Tnfsf12) and the receptor, fibroblast growth factor-inducible 14 (Fn14), regulates vascular damage through different mechanisms, including inflammation. " 07/01/2011 - "TNF-like weak inducer of apoptosis (TWEAK) and fibroblast growth factor (FGF)-inducible 14 (Fn14) are a TNF superfamily ligand-receptor pair involved in many cellular processes including proliferation, migration, differentiation, inflammation, and angiogenesis. " 01/01/2011 - "TNF-like weak inducer of apoptosis (TWEAK) binds to its receptor, fibroblast growth factor-inducible 14 (Fn14), and controls many cellular activities, including proliferation, migration, differentiation, apoptosis, angiogenesis, and inflammation. " 01/01/2011 - "Through activation of the fibroblast growth factor-inducible 14 (Fn14) receptor, TWEAK regulates cell proliferation, cell death and inflammation. "
5.	Anoxia (Hypoxia) 11/01/2015 - "Hypoxia-induced fibroblast growth factor 11 stimulates capillary-like endothelial tube formation." 12/01/1993 - "Psychometric analysis in children with mental retardation due to perinatal hypoxia treated with fibroblast growth factor (FGF) and showing improvement in mental development." 07/01/2015 - "The early phase of hypoxia induced a significantly lower increase in fibroblast growth factor receptor-1 (FGFR1) protein level and receptor phosphorylation, and reduced pulmonary artery smooth muscle cell (PASMC) proliferation in Hspg2(Δ3/Δ3). " 03/19/2015 - "Fibroblast growth factor and endothelin-1 receptors mediate the response of human striatal precursor cells to hypoxia." 01/01/2012 - "The cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) are found in neurons and their expression is induced by exposure to sub-lethal hypoxia. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Intercellular Signaling Peptides and Proteins (Growth Factors)
3.	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)
4.	Platelet-Derived Growth Factor
5.	Transforming Growth Factor beta (TGF-beta)
6.	Insulin (Novolin)
7.	Transforming Growth Factors (Transforming Growth Factor)
8.	Cytokines
9.	Proteins (Proteins, Gene)
10.	BMS 540215

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1.	Transplants (Transplant)
2.	Transplantation (Transplant Recipients)
3.	Biological Therapy
4.	Lasers (Laser)
5.	Bariatric Surgery