Azoospermia

01/01/2020 - "It was concluded that both treatments were effective in inhibiting the reproductive axis; however, neither of them produced azoospermia or decreased testosterone concentrations to undetectable levels. "
01/01/1998 - "Our data may also help to explain the greater efficacy of testosterone-induced spermatogenic suppression to azoospermia observed in Asian compared to non-Asian men."
06/17/2021 - "In this study we aimed to investigate whether serum concentrations of AMH and the AMH to total testosterone ratio (AMH/T) might be predictive factors for sperm retrieval outcomes during TESE in a cohort of 155 adult Caucasian men with azoospermia. "
01/01/2020 - "In this study, we investigated the risk of azoospermia and testosterone deficiency, the diagnostic value of markers of spermatogenesis, and paternity at long-term follow-up after pediatric allogeneic HSCT. "
09/01/2014 - "Several trials aimed at improving the sperm retrieval from men with non-obstructive azoospermia (NOA) by optimizing intratesticular testosterone (ITT) have reported partial responses, however, an appropriate level of ITT has not been identified. "

10/20/1990 - "A multicentre study (ten centres) in seven countries was done to assess the contraceptive efficacy of hormonally-induced azoospermia in 271 healthy fertile men. "
04/15/2015 - "The complete azoospermia confirms its contraceptive effect. "
01/01/2002 - "Data from monkeys and men treated with steroidal contraceptives indicate that impairment of spermiation is a key to achieving azoospermia. "
04/01/2001 - "Human male hormonal contraceptive regimens do not consistently induce azoospermia, and the basis of this variable response is unclear. "
09/01/1999 - "The rationale and technique underlying a novel concept of non-invasive removal of an intravasal vas deferens polymeric contraceptive drug to reverse drug injection-induced azoospermia are explained. "

05/01/1995 - " One multicenter study injected men weekly with testosterone enanthate to induce azoospermia. "
01/01/1995 - "Factors in nonuniform induction of azoospermia by testosterone enanthate in normal men. "
11/01/1985 - "Testosterone enanthate, given on a weekly or bimonthly basis, failed to predictably induce azoospermia in men. "
01/01/1995 - " Weekly injections of testosterone enanthate (TE) produced azoospermia in most men. "
03/01/1987 - "To learn more about the post-vasectomy autoimmune antisperm reaction, vasectomy was performed on 2 subjects who had achieved azoospermia through the administration of 250 mg/week of testosterone enanthate. "

08/01/2002 - "Although more efficacious than T patch alone, Norplant II or oral LNG plus T patch was not as effective in suppressing spermatogenesis to severe oligo- or azoospermia as in previous reports using oral LNG plus TE. "
03/14/2012 - "5) TU 500 mg was less likely to produce azoospermia than TU 1000 mg (with levonorgestrel implants). "
12/01/2001 - "The primary aim of the present study was to determine the therapeutic dose of subcutaneous levonorgestrel (LNG) to induce azoospermia or severe oligozoospermia (<3 x 10(6)/mL) in normal men requiring contraception. "
02/01/2005 - "The addition of levonorgestrel 500 microg po daily improved the effectiveness of testosterone enanthate 100 mg im weekly by itself (OR for azoospermia with the combined regimen, 4.0; 95% CI, 1.00-15.99). "
01/01/2004 - "The addition of levonorgestrel 500 mcg by mouth daily improved the effectiveness of testosterone enanthate 100 mg IM weekly by itself (OR for azoospermia with the combined regimen 4.0; 95%CI 1.00-15.99). "

04/01/2023 - "Azoospermia cases secondary to high androgen levels are frequently encountered in LCTs. "
08/01/2012 - "Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu."
03/20/2006 - "Serum T decreased significantly at follow-up (p < 0.05) and 5/31 (16%) de novo androgen deficiencies developed In patients with non-obstructive azoospermia in whom no spermatozoa were found following a micro epididymal sperm aspiration and a simple testicular biopsy, we were able to retrieve spermatozoa in 35% of the men. "
03/20/2006 - "Long term effects of micro-surgical testicular sperm extraction on androgen status in patients with non obstructive azoospermia."
01/01/2004 - "However, in contrast to East Asian men, only two-thirds of Caucasian men respond to such androgen-based regimens with the desired azoospermia (no sperm produced), and thus additional agents are required. "

10/01/1983 - "Azoospermia was, however, not achieved even after 22 weeks of treatment although in a previous study in which the LHRH agonist had been administered alone, azoospermia had been achieved after 8-10 weeks. "
10/01/1996 - "The results indicate that immunoneutralization of GnRH induced complete azoospermia, and subsequent treatment with DHT implants of 2 or 4 cm for 8 wk restored accessory organ weights, but did not restore spermatogenesis or fertility. "
10/01/1996 - "Twenty-five sexually mature male rats of proven fertility were actively immunized against gonadotropin releasing hormone (GnRH) to induce azoospermia. "
10/01/1996 - "Genetic defects are associated with a variety of clinical presentations by the infertile man ranging from gonadotropin-releasing hormone deficiency to spermatogenic failure to obstructive azoospermia. "
10/01/1994 - "A GnRH challenge test was made in both groups, two days after we perform a testicular biopsy in patients with azoospermia. "

05/27/2023 - "Availability and adoption of such non-invasive molecular biomarkers would represent a great improvement in reproductive treatment decision protocols for azoospermia in clinical practice."
08/01/2023 - "Thus, our study underscores the potential of TIF in sperm retrieval biomarker discovery and would serve as a foundation for further studies to improve treatment strategies against azoospermia. "
01/01/2023 - "In the last two decades, there have been many proteomics studies investigating potential azoospermia biomarkers. "
07/22/2022 - "This study identified that the extracellular vesicles tRF-Val-AAC-010 and tRF-Pro-AGG-003 are biomarkers for the diagnosis of non-obstructive azoospermia, and that tRF-Val-AAC-010 as a potential non-invasive biomarker for predicting the presence of sperm in non-obstructive azoospermia testicular tissue."
07/20/2019 - "The aim of this study was to investigate the relationship of the CD133 and CD24 genes with spermatogenesis defects and examine them as a candidate a useful biomarker for azoospermia men. "

08/01/1999 - "Testis tissues from a patient with idiopathic azoospermia and from a normal fathered man were investigated with an improved mRNA differential display approach. "
03/01/2020 - "This study applied cfs-mRNA of ESX1, ZMYND15 and its target haploid genes (TNP1 and PRM1) to identify the presence of spermatozoa in men with azoospermia. "
05/01/2018 - "Ninety male participants were included in the study, among which 47 were with normozoospermia, 36 with impaired semen characteristics according to the World Health Organization (WHO) manual, 5th edition, and 7 with azoospermia serving as negative control for the PIWI-LIKE 1-4 mRNA expression in somatic cells in the ejaculate. "
01/01/2017 - "In this study, we examined DNA methylation and mRNA expression status in a set of testicular tissues of SO patients (n = 3), and compared methylated data with those derived from obstructive azoospermia (OA) patients (n = 3) with normal spermatogenesis phenotype. "
04/01/2012 - "This study applied cfs-mRNA in identifying the presence of either germ cells or complete obstruction in men with azoospermia. "

06/01/2003 - "Steroid-induced azoospermia that is persistent after cessation of steroid use can be treated successfully with hCG and hMG."
04/01/2011 - "Testicular masses vanished after administering steroids, and azoospermia recovered. "
08/01/1997 - "Little literature exists on the treatment of steroid-induced azoospermia following the cessation of abuse. "
04/01/1996 - " Moreover, significant population differences have been found in the extent of sex steroid-induced spermatogenesis suppression required to achieve azoospermia within 6 months of treatment. "
01/01/1979 - "II. Serum steroid levels in obstructive azoospermia."

02/01/1996 - "Previous studies of T and progestogen combinations have shown comparable rates of azoospermia, but have been uncontrolled or used T in doses less than that associated with maximal suppression of sperm production. "
02/01/2002 - "Suppression of spermatogenesis to azoospermia is the goal of hormonal male contraception based on T combined with gestagens. "
07/01/2000 - "Marked suppression of gonadotrophins in both treatment groups resulted in azoospermia in 8/14 and 7/14 volunteers and severe oligozoospermia (< 3 x 1012/l) in 4/14 and 7/14 in the placebo and gestagen treated groups, respectively. "
05/01/1998 - " For both androgens alone and androgens in combination with a progestin, the suppression of spermatogenesis to persistent azoospermia occurred in about 90% of Asian men compared to 60-70% of Caucasians. "
08/01/1991 - "Reversible azoospermia induced by an androgen-progestin combination regimen in Indonesian men."

10/01/1998 - "Physicians' variations in occlusion methods, use of fascial interposition, and postvasectomy protocols underscore the need for large scale, controlled, and statistically valid studies to determine the efficacy of occlusion methods and fascial interposition, as well as whether azoospermia is the only determination of a successful vasectomy."
05/01/2004 - "Vasal perfusion with saline during vasectomy was effective in removing sperm from the distal vas; however, perfusion did not increase the rate at which men achieve azoospermia."
10/01/2022 - "Vasectomy is a safe and effective technique to achieve azoospermia, although the failure rate of the technique is less than 1%. "
04/01/2015 - "The study included men undergoing MESA or TESE at St. Luke's Hospital for obstructive azoospermia due to CBAVD or vasectomy. "
04/01/2015 - "Our study suggests that proximal epididymal sperm (from MESA) result in higher live birth rates as compared with testicular sperm (from TESE) in couples where the man has obstructive azoospermia due to congenital bilateral absence of the vas deferens (CBAVD) or vasectomy. "

01/01/2016 - "In the setting of azoospermia owing to spermatogenic dysfunction, hormonal therapy - relying on truly objective parameters including the return of sperm to the ejaculate or successful surgical sperm retrieval - is a promising treatment. "
01/01/2023 - "Efficacy of Cellular Therapy for Azoospermia in Animal Models: A Systematic Review and Meta-Analysis."
01/01/2016 - "To validate the efficacy of salvage hormonal therapy in men with non-obstructive azoospermia at their second microdissection testicular sperm extraction. "
01/01/2021 - "To date, no randomized and controlled study has demonstrated the effect of adjuvant medical therapy on testicular sperm production before the sperm retrieval procedures in men with non-obstructive azoospermia (NOA). "
10/01/2012 - "The same patient underwent a trial of GH replacement therapy with poor response and his sperm analysis revealed azoospermia. "

02/18/1991 - " The goal of this preliminary study was to determine if azoospermia was necessary or sufficient for effective contraception. "
07/01/2022 - "A high percentage of responders reported permitting unprotected intercourse only if PVSA samples show azoospermia while, in the presence of few non-motile sperm, the majority of responders suggested using alternative contraception, followed by another PVSA. "
11/30/2007 - "Complete azoospermia might not be necessary in order to achieve an acceptable failure rate compared with other forms of male fertility control. "
11/01/2003 - "Hormonal male contraception aims at suppression of spermatogenesis to azoospermia or at least to severe oligoasthenozoospermia, incompatible with the ability to induce a pregnancy. "
11/01/2002 - "Suppression of spermatogenesis to azoospermia is required for effective hormonal male contraception, but the degree of suppression varies between ethnic groups. "

01/01/2020 - "Vasovasostomy remains highly efficacious in treating obstructive azoospermia. "
03/01/2015 - "This study included 76 patients with obstructive azoospermia, 53 treated by bilateral vasoepididymostomy (8 involving the epididymal head, 18 involving the epididymal body, 5 involving the epididymal tail, and 22 involving the epididymal head, body and tail), 14 by unilateral vasoepididymostomy, and the other 9 by unilateral vasoepididymostomy + unilateral vasovasostomy (including cross anastomosis). "
05/01/2005 - "The results of our study demonstrated that secondary azoospermia after vasovasostomy is rare. "
08/01/2020 - "We retrospectively analyzed the clinical data on 41 cases of microscopic vasovasostomy for obstructive azoospermia in our hospital from July 2015 to September 2018. "
01/01/2020 - "To assess the timing of patency and late failure (secondary azoospermia) after vasovasostomy (VV) using standardized kinetics definitions. "

02/01/2005 - "We conducted a systematic review of all randomized controlled trials of male hormonal contraception and azoospermia. "
07/01/2002 - "These results imply that FSH plays a key role in supporting spermatogenesis in monkeys in this experimental regimen and suggest that maximal suppression of FSH may be essential to ensure consistent azoospermia in men during hormonal contraception."
05/16/2006 - "Hormonal contraception for men interrupts this physiological axis by various means of gonadotrophin suppression; this interferes with spermatogonial differentiation and meiosis entry resulting in reversible azoospermia or severe oligozoospermia in virtually all men. "
10/01/1996 - "Male hormonal contraception has been limited to date because two fundamental requirements have not been concurrently satisfied, these are, consistent and dependable azoospermia and infertility coupled with maintenance of libido. "
01/01/1999 - "From these preclinical studies, it can be concluded that in men, applying hormonal contraception precautions against pregnancy must be recommended before azoospermia is induced, since the epididymis can partially compensate for poor-quality sperm produced by a regressing testis even when levels of circulating androgens and tissue androgens are low."