Zonula Occludens-2 Protein

A zonula occludens protein subtype found in epithelial cell junctions. Several isoforms of zonula occludens-2 protein exist due to use of alternative promoter regions and alternative mRNA splicings.

Also Known As:

Tight Junction Protein 2; Zonula Occludens-2 Protein Isoform A1; Zonula Occludens-2 Protein Isoform C1; Zonula Occludens 2 Protein; Zonula Occludens 2 Protein Isoform A1; Zonula Occludens 2 Protein Isoform C1; Zona Occludens 2 Protein

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Tight Junction Proteins: 1698
      - Zonula Occludens Proteins: 2
        Zonula Occludens-2 Protein: 11
        human TJP2 protein
        mouse Tjp2 protein
        rat Tjp2 protein
        zebrafish tjp2a protein

Experts

1.	Sambrotta, Melissa: 3 articles (04/2022 - 04/2014)
2.	Thompson, Richard J: 3 articles (04/2022 - 04/2014)
3.	Knisely, A S: 2 articles (12/2015 - 04/2014)
4.	Asai, Akihiro: 1 article (04/2022)
5.	Baker, Oliver: 1 article (04/2022)
6.	Blackford, Samuel J I: 1 article (04/2022)
7.	Chen, Xindi: 1 article (04/2022)
8.	Danovi, Davide: 1 article (04/2022)
9.	Fukami, Aiko: 1 article (04/2022)
10.	Hayashi, Hisamitsu: 1 article (04/2022)

Related Diseases

1.	Lung Injury 05/01/2019 - "LPS stimulation significantly increased the pulmonary permeability and decreased the expression of SIRT1 and tight junction proteins (TJs), including occludin, claudin-5, tight junction protein 1 and tight junction protein 2. Morphological studies showed that LPS induced obvious lung injury with inflammatory cell infiltration in the interstitial and alveolar space, hemorrhage, edema, and the thickened alveolar wall compared to the control mice. "
2.	Hemorrhage 05/01/2019 - "LPS stimulation significantly increased the pulmonary permeability and decreased the expression of SIRT1 and tight junction proteins (TJs), including occludin, claudin-5, tight junction protein 1 and tight junction protein 2. Morphological studies showed that LPS induced obvious lung injury with inflammatory cell infiltration in the interstitial and alveolar space, hemorrhage, edema, and the thickened alveolar wall compared to the control mice. "
3.	Edema (Dropsy) 05/01/2019 - "LPS stimulation significantly increased the pulmonary permeability and decreased the expression of SIRT1 and tight junction proteins (TJs), including occludin, claudin-5, tight junction protein 1 and tight junction protein 2. Morphological studies showed that LPS induced obvious lung injury with inflammatory cell infiltration in the interstitial and alveolar space, hemorrhage, edema, and the thickened alveolar wall compared to the control mice. "
4.	progressive familial intrahepatic 1 Cholestasis 02/07/2020 - "New tight junction protein 2 variant causing progressive familial intrahepatic cholestasis type 4 in adults: A case report." 01/01/2016 - "Japanese scholars have proposed that mutation in the gene encoding the tight junction protein 2 (TJP2) may result in progressive familial intrahepatic cholestasis type 4. Gaining a detailed understanding of the pathogenesis of this disease form, and of its molecular underpinnings, will promote the development of new and more effective diagnostic tools for infantile progressive familial intrahepatic cholestasis. " 01/13/2022 - "One patient each with familial intrahepatic cholestasis 1 (FIC1) deficiency and bile salt export pump (BSEP) deficiency died after LDLT, and the four remaining patients, one each with deficiency of FIC1, BSEP, multidrug resistance protein 3 (MDR3), and tight junction protein 2 (TJP2), survived. "
5.	Hepatocellular Carcinoma (Hepatoma) 11/01/2017 - "Paediatric hepatocellular carcinoma in tight junction protein 2 (TJP2) deficiency." 12/01/2015 - "Hepatocellular carcinoma associated with tight-junction protein 2 deficiency."

Related Drugs and Biologics

1.	Occludin
2.	Zonula Occludens-1 Protein
3.	Tight Junction Proteins
4.	Claudin-5
5.	Sirtuin 1
6.	Proteins (Proteins, Gene)
7.	Mucin-2
8.	Interleukin-10 (Interleukin 10)
9.	Interleukin-6 (Interleukin 6)
10.	Transforming Growth Factors (Transforming Growth Factor)