Mucin-2

A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.

Also Known As:

Networked: 147 relevant articles (4 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bartlett, David L: 5 articles (01/2020 - 10/2015)
2.	Choudry, Haroon A: 5 articles (01/2020 - 10/2015)
3.	Lee, Yong J: 5 articles (01/2020 - 10/2015)
4.	Sjölander, Anita: 4 articles (08/2020 - 11/2016)
5.	Dilly, Ashok K: 4 articles (01/2020 - 10/2015)
6.	Gibson, Deanna L: 3 articles (01/2022 - 01/2021)
7.	Haskey, Natasha: 3 articles (01/2022 - 01/2021)
8.	Mehdawi, Lubna M: 3 articles (08/2020 - 11/2016)
9.	Honick, Brendon D: 3 articles (01/2020 - 12/2017)
10.	Guo, Yuming: 3 articles (08/2018 - 01/2012)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2022 - "Recent studies have also demonstrated the expression of the gel-forming mucin 2 (MUC2) in EMPSGC, possibly signifying a lacrimal or conjunctival origin of these neoplasms. " 07/07/2021 - "Abnormal expression patterns of mucin 2 (MUC2) have been reported in a variety of malignant tumors and precancerous lesions. " 03/01/2017 - "Mucin 2 (MUC2) protects colon tissues from the formation of tumors. " 01/01/2020 - "We investigated the efficacy of dual MEK-PI3K drug therapy against KRAS mutated mucin 2 (MUC2)-secreting LS174T cells and patient-derived ex vivo and in vivo models of KRAS mutated mucinous colon/appendix cancers. " 03/01/2016 - "Targeting hypoxia-mediated mucin 2 production as a therapeutic strategy for mucinous tumors."
2.	Necrosis 08/01/2022 - "Interestingly, greater expression of tumour necrosis factor α (TNF-α) and mucin 2 (MUC2) genes (P = 0.039 and P = 0.067, respectively) were detected in the group receiving salinomycin.5. These effects may have collectively contributed to the significantly improved performance of broilers supplemented with salinomycin. " 07/01/2019 - "The EGCG supplementation promoted the gene expression of nuclear factor-erythroid 2-related factor 2 (Nrf2), Claudin-1, Mucin 2 (Muc2) and alleviated the nuclear factor-kappa B (NF-κB) and lipopolysaccharide-induced tumour necrosis factor (LITAF) gene expression compared with group HS0 (p < 0.05). " 08/01/2017 - "In addition, levels of intestinal mRNA expression of interleukin (IL)-4, IL-9, stem cell factor (SCF), type I and II interferons (IFN)-α/ γ, tumour necrosis factor (TNF)-α, mucin 2 (MUC2) and inducible nitric oxide synthase (iNOs) were investigated using real-time PCR. " 05/01/2022 - "In terms of specific transcripts of interest, pro-inflammatory cytokines (interleukin 1β and tumour necrosis factor), annexin A1, mucin 2, and calreticulin were upregulated, while cathepsin H, mucin 5AC, and perforin 1 were downregulated in lesion tissue. " 01/01/2020 - "Gene expression of interleukin (IL)-4, IL-5, IL-6, IL-10, IL-13, IL-17A, IL-22, IFN-γ, resistin-like molecule beta (RELM-β), Mucin 2 (MUC2) and tumour necrosis factor (TNF)-α was measured using qRT-PCR. "
3.	Body Weight (Weight, Body) 01/03/2023 - "Compared to the ZnSO4 group, we found that supplementation with Zn-Gly resulted in the significant increase of body weight at 35 d, 1 to 35 d average daily gain and average daily feed intake, villus height at 14 and 35 d, secretory immunoglobulin A and immunoglobulin G at 14 d, and mucin 2 mRNA level at 14 d. " 01/03/2023 - "Additionally, compared to the ZnSO4 group, we found that supplementation with Zn-Gly at 70 mg/kg Zn resulted in the significant increase of body weight at 35 d, 1 to 35 d ADG and average daily feed intake, villus height at 14 and 35 d, secretory immunoglobulin A and immunoglobulin G at 14 d, and mucin 2 mRNA level at 14 d (P < 0.05). " 11/01/2016 - "This cell-specific deletion of Metrnl did not affect body weight, food intake, blood glucose, colon length and histology, intestinal permeability, mucus content or mucin 2 expression under physiological conditions, but statistically decreased the expression of antimicrobial peptides, such as regenerating islet-derived 3 gamma (Reg3g) and lactotransferrin. " 01/20/2023 - "(1) Compared with birds in ST, AC supplementation increased the body weight (BW) at d 18 and the average daily gain (ADG) from d 1 to 18 of the Salmonella-infected chickens (P < 0.05); (2) AC decreased the number of Salmonella cells in the liver and spleen, the contents of NO in plasma and inflammatory cytokines in ileal mucosa of Salmonella-infected chickens (P < 0.05); (3) Salmonella infection decreased the ileal villi height, villi height to crypt depth (V/C), and the expression of zonulaoccludins-1 (ZO-1), claudin-1, occludin, and mucin 2 (MUC2) in ileal mucosa. " 01/03/2023 - "After 14 and 35 d of feeding, birds in the Zn groups had significantly increased body weight and average daily gain (ADG), decreased intestinal permeability indicator d-lactate, improved intestinal morphology and barrier function-related tight junction protein levels, and upregulated mucin 2 and secretory immunoglobulin A levels compared to the control (P < 0.05). "
4.	Alcoholic Liver Diseases (Alcoholic Liver Disease) 07/01/2013 - "Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice." 01/01/2022 - "Alcohol-induced thickening of the gut mucosal layer and increased expression of goblet cell gel-forming mucins, such as mucin-2 (MUC2) are associated with disruptions to the gut barrier in alcoholic liver disease (ALD). "
5.	Colitis 10/20/2023 - "Composed primarily of Mucin-2, proteolytic erosion of this barrier is an invariant feature of colitis; however, the molecular mechanisms are not well understood. " 01/01/2022 - "A Mediterranean-like fat blend protects against the development of severe colitis in the mucin-2 deficient murine model." 01/01/2021 - "Deletion of mucin 2 induces colitis with concomitant metabolic abnormalities in mice." 01/01/2021 - "In this study, a spontaneous model of colitis (mucin 2 knock-out mouse, Muc2-/-) was used to investigate the impact of intestinal disease on metabolic dysfunction. " 12/03/2020 - "In this study, we used Mucin-2 (Muc2) knockout mice predisposed to colitis to study intestinal barrier upon chronic inflammation. "

Related Drugs and Biologics

1.	Tight Junction Proteins
2.	Secretory Immunoglobulin A (SIgA)
3.	Lactic Acid (Lactate)
4.	Indicators and Reagents (Reagents)
5.	salinomycin
6.	Keratin-20 (Cytokeratin 20)
7.	Proteins (Proteins, Gene)
8.	Mucins
9.	Occludin
10.	Cytokines

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Cystectomy
3.	Oral Administration