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Oxycodone (Oxycontin)

A semisynthetic derivative of CODEINE.

Also Known As:

Oxycontin; Dihydrohydroxycodeinone; Dihydrone; Dinarkon; Eucodal; Oxycodone Hydrochloride; Oxycone; Pancodine; Purdue Frederick Brand of Oxycodone; Theocodin; Oxiconum; Oxycodeinon; Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5alpha)-

Networked: 931 relevant articles (159 outcomes, 307 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Upmalis, David: 12 articles (08/2013 - 11/2008)
2.	Etropolski, Mila: 11 articles (11/2015 - 06/2010)
3.	Suzuki, Tsutomu: 11 articles (04/2015 - 01/2008)
4.	Okamoto, Akiko: 11 articles (08/2013 - 11/2008)
5.	Hopp, Michael: 10 articles (12/2015 - 11/2008)
6.	Kokki, Hannu: 10 articles (12/2015 - 01/2003)
7.	Arendt-Nielsen, Lars: 10 articles (08/2015 - 07/2006)
8.	Matoba, Motohiro: 10 articles (12/2014 - 03/2005)
9.	Richards, Patricia: 10 articles (08/2013 - 03/2003)
10.	Benson, Carmela: 9 articles (10/2015 - 05/2011)

Related Diseases

1.	Pain (Aches) 03/01/2010 - "Oxycodone CR appears to be a very well tolerated and effective treatment for patients with visceral pain." 04/01/1999 - "Following titration with immediate release oxycodone, mean (SE) pain intensity (0, none to 3, severe) decreased from 2.44 (0.04) to 1.38 (0.05) (p=0.0001), and quality of sleep (1, very poor; 5, excellent) improved from 2.58 (0.08) to 3.57 (0.07) (p=0.0001). " 09/01/2011 - "Gel-cap oxycodone extended-release met the primary end point of significantly improved mean pain intensity scores compared with placebo in a Phase III, placebo-controlled trial. " 07/01/1996 - "Treatment with CR oxycodone was safe and effective in this study, and its characteristics will be beneficial in the treatment of pain." 04/01/2005 - "The summed pain intensity difference over 7 observations was significantly greater in the oxycodone group, 22 +/- 18 cm, than in the placebo group, 9 +/- 12 cm (mean difference 13 cm, with a 95% confidence interval of 2-24 cm; P = .04). "
2.	Neoplasms (Cancer) 01/01/2004 - "To assess clinical efficacy of controlled-release oxycodone (CRO) 20 mg on a 12-h dosing schedule in this prospective, randomised, placebo-controlled, double-blinded study of 40 ASA physical status I-III women undergoing breast surgery for cancer. " 03/01/2015 - "To evaluate the efficacy of preemptive intravenous oxycodone in the patients undergoing laparoscopic resection of ovarian tumor. " 01/01/2015 - "The participants of this study were 156 hospitalized cancer patients who underwent opioid switching from oral oxycodone to TDF at the Affiliated Hospital of Binzhou Medical University between January 1st, 2010 and March 31st, 2014. " 02/01/2014 - "This study aimed to investigate whether the characteristics of patients with advanced cancer explain the variability in oxycodone clearance, with the potential for this information to determine maintenance dosing. " 04/01/2012 - "Is saliva a valid substitute for plasma in pharmacokinetic studies of oxycodone and its metabolites in patients with cancer?"
3.	Constipation 04/01/2009 - "Discontinuing participation in the trial, primarily associated with constipation, occurred more frequently in subjects randomized to CR-oxycodone (27.6%) compared with placebo (6.9%). " 01/01/2011 - "After an increase in the dosage of oxycodone, he complained of abdominal distension and constipation. " 05/01/2013 - "Vomiting (odds ratio [95% CI], 1.74 [1.17 - 2.57]) and constipation (3.43 [1.45 - 8.11]) were significantly more likely to occur in the oxycodone IR treatment group. " 01/01/2011 - "The patient had taken oxycodone for several months and had never complained of either diarrhea or constipation. " 02/01/2004 - "Overall, oxycodone controlled-release patients had a significantly greater risk of developing constipation compared with transdermal fentanyl patients (transdermal fentanyl: n = 877; oxycodone controlled-release: n=1,218; OR = 2.55; 95% CI = 1.33-4.89; P = 0.005). "
4.	Low Back Pain (Lumbago) 10/01/1999 - "In a study of similar design, 57 patients with low back pain were titrated with either CR or IR oxycodone (maximum dose, 80 mg/day) for a period of up to 10 days. " 05/01/2011 - "Long-term safety of Remoxy® (extended-release oxycodone) in patients with moderate to severe chronic osteoarthritis or low back pain." 08/01/2010 - "Tapentadol ER (100 - 250 mg b.i.d.) effectively relieved moderate to severe chronic low back pain over 15 weeks and had better gastrointestinal tolerability than oxycodone HCl CR (20 - 50 mg b.i.d.)." 01/01/2005 - "Oxymorphone ER and oxycodone CR were generally safe and effective for controlling low back pain. " 10/01/2015 - "Validation analyses were conducted on data from a randomized, double-blind, parallel-group study of tapentadol immediate release vs oxycodone immediate release for acute low back pain (N = 666). "
5.	Osteoarthritis 11/01/2005 - "Daily functioning, as measured by the Western Ontario and McMaster Universities Osteoarthritis Index, was also significantly improved in the controlled-release oxycodone group. " 01/01/2012 - "Controlled release formulation of oxycodone in patients with moderate to severe chronic osteoarthritis: a critical review of the literature." 01/01/2006 - "Beyond significant pain control and better physical function, controlled-release oxycodone improved coping with pain in patients with osteoarthritis." 01/01/2006 - "The psychometric properties of the Brief Pain Inventory (BPI), a widely used measure of pain and its impact on functioning, were assessed using data from two clinical trials of controlled-release oxycodone in osteoarthritis (OA) patients. " 03/27/2000 - "Around-the-clock, controlled-release oxycodone therapy for osteoarthritis-related pain: placebo-controlled trial and long-term evaluation."

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	3- (3- dimethylamino- 1- ethyl- 2- methylpropyl)phenol
3.	Naloxone (Narcan)
4.	Opioid Analgesics (Opioids)
5.	Oxycodone (Oxycontin)
6.	Fentanyl (Sublimaze)
7.	Acetaminophen (Paracetamol)
8.	Tablets
9.	Hydromorphone (Dilaudid)
10.	Methadone (Dolophine)

Related Therapies and Procedures

1.	Analgesia
2.	Injections
3.	Therapeutics
4.	Premedication
5.	Anesthesia