Cyclin G2

An unusual cyclin subtype that is found highly expressed in terminally differentiated cells. Unlike conventional cyclins increased expression of cyclin G2 is believed to cause a withdrawal of cells from the CELL CYCLE.

Networked: 50 relevant articles (0 outcomes, 18 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Cell Cycle Proteins: 807
    - Cyclins: 3150
      - Cyclin G: 38
        Cyclin G2: 50
        human CCNG2 protein
  - Intracellular Signaling Peptides and Proteins: 32
    - Cyclins: 3150
      - Cyclin G: 38
        Cyclin G2: 50
        human CCNG2 protein
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Cyclins: 3150
      - Cyclin G: 38
        Cyclin G2: 50
        human CCNG2 protein

Experts

1.	Luo, Yang: 10 articles (08/2021 - 06/2002)
2.	Liu, Qi: 8 articles (08/2021 - 01/2018)
3.	Gao, Jinlan: 7 articles (08/2021 - 01/2018)
4.	Zhao, Chenyang: 7 articles (08/2021 - 01/2018)
5.	Li, Sen: 6 articles (08/2021 - 01/2018)
6.	Xing, Xuesha: 6 articles (08/2021 - 01/2018)
7.	Hou, Xiaoyu: 5 articles (01/2020 - 01/2018)
8.	Sun, G G: 5 articles (04/2014 - 03/2014)
9.	Wang, Shusen: 3 articles (08/2021 - 01/2018)
10.	Zhuang, Xinbin: 3 articles (08/2021 - 01/2019)

Related Diseases

1.	Carcinoma (Carcinomatosis) 04/01/2014 - "This study aimed to analyze the expression, clinical significance of cyclin G2 (CCNG2) in esophageal carcinoma, and the biological effect in its cell line by CCNG2 overexpression. " 04/01/2014 - "This study aimed to analyze the expression, clinical significance of cyclin G2 (CCNG2) in prostate carcinoma, and the biological effect in its cell line by CCNG2 overexpression. " 04/01/2014 - "This study aims to analyze the expression and clinical significance of cyclin G2 (CCNG2) in kidney carcinoma, and the biological effect in its cell line by CCNG2 overexpression. " 03/01/2014 - "This study aimed to analyze the expression, clinical significance of cyclin G2 (CCNG2) in gastric carcinoma, and the biological effect in its cell line by CCNG2 overexpression. " 05/01/2003 - "However, little is known about the cyclin G2 expression in human carcinomas. "
2.	Neoplasms (Cancer) 01/01/2016 - "In vitro and in vivo studies using several EOC-derived tumor cell lines revealed that cyclin G2 inhibited cell proliferation, migration, invasion and spheroid formation, as well as tumor formation and invasion. " 06/01/2002 - "The current study was aimed at clarifying the effects of cyclin G2 transgene expression on proliferation of cancer cells in vitro. " 12/24/2022 - "Cyclin G2 is upregulated by IFN-γ in macrophages, promotes the secretion of CXCL9 to increase CTL chemotaxis and inhibit angiogenesis to suppress tumor growth. " 12/24/2022 - "Mouse tumor models were used to determine the effect of cyclin G2 in macrophages on tumor growth in vivo following IFN-γ treatment. " 12/24/2022 - "Cyclin G2 functions as a tumor suppressor in various cancer cells; however, its role in macrophages remains unclear. "
3.	Squamous Cell Carcinoma of Head and Neck 01/01/2020 - "This study aimed to investigate the effect of cyclin G2 on oral squamous cell carcinoma (OSCC). " 01/01/2015 - "Our previous study found that miR-93 was significantly upregulated in laryngeal squamous cell carcinoma (LSCC), and cyclin G2 (CCNG2) was a potential target of miR-93 in LSCC. " 01/01/2015 - "MicroRNA-93 regulates cyclin G2 expression and plays an oncogenic role in laryngeal squamous cell carcinoma." 06/01/2002 - "Furthermore, down-regulated cyclin G2 was detected in oral squamous cell carcinomas. " 01/01/2020 - "Cyclin G2 Inhibits Oral Squamous Cell Carcinoma Growth and Metastasis by Binding to IGFBP3 and Regulating the FAK-SRC-STAT Signaling Pathway."
4.	Breast Neoplasms (Breast Cancer) 11/01/2007 - "The purpose of this study was to explore how HER2 signaling modulates cyclin G2 expression and the effect of elevated cyclin G2 on breast cancer cell growth. " 11/01/2007 - "Enforced expression of HER2 in T47D and MDAMB435 breast cancer cells reduced cyclin G2 levels. " 11/01/2007 - "The negative effects of cyclin G2 on cell cycle and cell proliferation, which occur without altering p27(Kip1) levels, may contribute to the ability of trastuzumab to inhibit breast cancer cell growth." 06/16/2006 - "We show that cyclin G2 is a primary ER target gene in MCF-7 breast cancer cells that is rapidly and robustly down-regulated by estrogen. " 12/01/2016 - "Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival."
5.	Stomach Neoplasms (Stomach Cancer) 12/14/2018 - "The effects of ectopic and endogenous cyclin G2 on the proliferation and migration of gastric cancer cells were assessed using the MTS assay, colony formation assay, cell cycle assay, wound healing assay and transwell assay. " 12/14/2018 - "TCGA datasets were used to evaluate the association between cyclin G2 expression and the prognostic landscape of gastric cancers. " 12/14/2018 - "Real-time PCR, immunohistochemistry and in silico assay were used to determine the expression of cyclin G2 in gastric cancer. " 12/01/2009 - "However, cyclin G2 appears to be a negative cell-cycle regulator in gastric cancer, and its expression seems to be inversely related to gastric cancer progression." 12/14/2018 - "We found that cyclin G2 levels were decreased in gastric cancer tissues and were associated with tumor size, migration and poor differentiation status. "

Related Drugs and Biologics

1.	Cyclins
2.	Catenins
3.	Cyclin A1
4.	Glypicans
5.	Apolipoproteins
6.	oxidized low density lipoprotein
7.	Proteins (Proteins, Gene)
8.	Messenger RNA (mRNA)
9.	cotylenin A
10.	Cyclin G1

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Immunotherapy