Glypicans

A family of GLYCOSYLPHOSPHATIDYLINOSITOL-anchored, cell-surface heparan sulfate proteoglycans that may play a role in CELL GROWTH PROCESSES and CELL DIFFERENTIATION by modulating ligand-receptor interactions.

Also Known As:

Networked: 1051 relevant articles (25 outcomes, 117 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nakatsura, Tetsuya: 38 articles (08/2020 - 06/2003)
2.	Ho, Mitchell: 31 articles (01/2022 - 01/2011)
3.	Yoshikawa, Toshiaki: 19 articles (08/2020 - 07/2009)
4.	Filmus, Jorge: 16 articles (01/2016 - 12/2002)
5.	Gao, Wei: 14 articles (03/2022 - 01/2011)
6.	Feng, Mingqian: 12 articles (01/2022 - 05/2011)
7.	Campbell, Douglas H: 11 articles (01/2022 - 01/2016)
8.	Walsh, Bradley J: 11 articles (01/2022 - 01/2016)
9.	Ohtomo, Toshihiko: 11 articles (11/2019 - 01/2011)
10.	Yao, Min: 11 articles (11/2016 - 06/2011)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "This was combined with an scFv/CD28 co-stimulatory molecule targeting glypican-3 for increased efficacy towards tumor cells. " 01/01/2020 - "We have evaluated safety and antitumor efficacy of CAR-T cells targeting glypican-1 (GPC1) overexpressed in various solid tumors. " 06/01/2017 - "Glypican-3 levels may help to stratify intermediate outcome histology (triphasic) and Stage III Wilms tumors." 09/04/2023 - "In this study, we aimed to endow NK cells with the ability to specifically target glypican-3+ tumor cells without producing cell damage or genetic alterations, and further evaluated their therapeutic efficiency. " 01/01/2023 - "Our study highlights the pitfalls of evaluating focal liver lesions in infants when high AFP levels and glypican-3 expression may reflect immaturity rather than neoplasia."
2.	Hepatocellular Carcinoma (Hepatoma) 07/01/2018 - "To determine the diagnostic accuracy of Glypican-3 in differentiating hepatocellular carcinoma from metastatic liver tumours while taking histopathology as the gold standard.. " 09/01/2023 - "RUNX-3-expressing CAR T cells targeting glypican-3 in patients with heavily pretreated advanced hepatocellular carcinoma: a phase I trial." 01/01/2023 - "The present study aims at establishing a noninvasive and reliable model for the preoperative prediction of glypican 3 (GPC3)-positive hepatocellular carcinoma (HCC) based on multiparametric magnetic resonance imaging (MRI) and clinical indicators. " 01/01/2023 - "Objectives: The aim of this study is to investigate the value of multi-phase contrast-enhanced magnetic resonance imaging (CE-MRI) based on the delta radiomics model for identifying glypican-3 (GPC3)-positive hepatocellular carcinoma (HCC). " 01/01/2023 - "Glypican 3 (GPC3) is a promising target for hepatocellular carcinoma (HCC), and CAR-T cells targeting GPC3 have been tested in clinical trials. "
3.	Liver Neoplasms (Liver Cancer) 05/01/2020 - "Recently, a series of studies have been published to examine the possible diagnostic and prognostic values of glypican-3 (GPC3) in liver cancer with conflicting results observed. " 11/01/2014 - "This study identified HS, partly through glypican-3, as a novel binding partner of GEP on the surface of liver cancer cells. " 01/01/2023 - "Inhibition of Glypican-3 Cleavage Results in Reduced Cell Proliferation in a Liver Cancer Cell Line." 05/01/2020 - "Diagnostic value of serum glypican-3 alone and in combination with AFP as an aid in the diagnosis of liver cancer." 01/01/2019 - "The Role of Glypican-3 in Regulating Wnt, YAP, and Hedgehog in Liver Cancer."
4.	Adenocarcinoma 11/01/2023 - "Retraction Note: Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways." 01/01/2022 - "The diagnostic performance and prognostic value of serum exosomal glypican 1 (GPC-1) in pancreatic ductal adenocarcinoma (PDAC) remain controversial. " 01/01/2022 - "Serum exosomal and serum glypican-1 are associated with early recurrence of pancreatic ductal adenocarcinoma." 01/01/2020 - "Glypican 6 is highly expressed in gastric adenocarcinoma and may act as a diagnostic and prognostic marker; however, the functional importance and molecular mechanism of glypican 6 in GC remains unclear. " 05/16/2019 - "Here, we sought to investigate the diagnostic and prognostic value of the expression of glypican 3 (GPC3) on primary gastro-esophageal adenocarcinoma (GEA) tissue (tGPC3) and corresponding serum exosomes (eGPC3). "
5.	Carcinoma (Carcinomatosis) 01/01/2020 - "The expression frequency and distribution of glypican-3 (GPC3) was retrospectively assessed by immunohistochemistry in 316 accurately phenotyped ovarian clear cell carcinoma (OCCC) specimens from Canadian patients. " 12/03/2019 - "Conjugates have been shown to specifically attach to urothelial carcinoma cells with high expression of Glypican-1. " 01/01/2019 - "Gene polymorphism rs1048369 of glypican-4 (GPC4) gene has been reported to be significantly different between Epstein-Barr virus (EBV)-associated gastric carcinoma (GC) and EBV-negative GC. " 01/01/2018 - "Napsin A is a more sensitive marker for endometrial clear cell carcinoma than glypican 3. In histologically ambiguous cases, napsin A and glypican 3 may help distinguish clear cell carcinoma from other high-grade histologies. " 01/01/2018 - "No cases of clear cell carcinoma that stained negative for napsin A stained positive for glypican 3. No difference in the immunohistochemical profile was found between pure and mixed clear cell carcinomas and between early- and advanced-stage clear cell carcinomas. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Chimeric Antigen Receptors
3.	alpha-Fetoproteins (alpha-Fetoprotein)
4.	Biomarkers (Surrogate Marker)
5.	Glypicans
6.	Antigens
7.	codrituzumab
8.	Protein Subunit Vaccines
9.	Enzymes
10.	Membrane Proteins (Integral Membrane Proteins)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Liver Transplantation
4.	Precision Medicine
5.	Photothermal Therapy