Cyclins

A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They generally function as ENZYME ACTIVATORS that drive the CELL CYCLE through transitions between phases. A subset of cyclins may also function as transcriptional regulators.

Also Known As:

Networked: 3646 relevant articles (40 outcomes, 348 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Grant, Steven: 21 articles (03/2014 - 02/2002)
2.	Pestell, Richard G: 16 articles (03/2014 - 04/2002)
3.	Musgrove, Elizabeth A: 15 articles (01/2015 - 01/2002)
4.	Dent, Paul: 15 articles (05/2014 - 09/2002)
5.	Sutherland, Robert L: 15 articles (01/2014 - 01/2002)
6.	Agarwal, Rajesh: 12 articles (05/2013 - 03/2003)
7.	Diehl, J Alan: 11 articles (11/2011 - 05/2002)
8.	Knudsen, Karen E: 10 articles (05/2015 - 08/2003)
9.	Knudsen, Erik S: 10 articles (08/2014 - 11/2002)
10.	Wang, Chenguang: 10 articles (03/2012 - 07/2002)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2001 - "The disease-free 5-year survival rate of patients with pRB+/cyclin D1- tumors was significantly better than that of other groups (P=0.001). " 10/16/2012 - "To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains that allow acute and global ablation of individual D-cyclins in a living animal. " 01/01/2014 - "In conclusion, the present study indicates anti-tumor effects of cyclin D1b in cervical cancer, suggesting that cyclin D1b may represent a potential therapeutic target for cervical cancer. " 01/01/2014 - "In this study, using a cervical cancer cell line with stable expression of cyclin D1b, we found that upregulation of cyclin D1b initiated cell cycle arrest at the G0/G1 phase and induced apoptosis, thereby inhibiting cell proliferation and colony formation. " 01/01/2014 - "Our previous study has reported low cyclin D1b expression in cervical cancer tissue, with an expression level in moderately or poorly differentiated tissues that was significantly lower than that in well-differentiated tissues. "
2.	Retinoblastoma (Glioblastoma, Retinal) 11/01/2006 - "The etiology of the tumour remains unclear, but molecular analysis studies have hypothesised the involvement of mutations of several genes in the pathogenesis of PC, including the oncogene cyclin Dl or PRADI located at the chromosome 13, the retinoblastoma and the p53 tumour suppressor gene. " 02/28/2014 - "Pin1 is required for cell cycle progression and loss of Pin1 causes cell cycle arrest in the G1 phase in CPCs, concomitantly associated with decreased expression of Cyclins D and B and increased expression of cell cycle inhibitors p53 and retinoblastoma (Rb). " 01/01/2012 - "At the molecular level, we found that ERβ downregulated total retinoblastoma (Rb), phosphorylated Rb and phospho-AKT cellular content as well as cyclins D1 and A2. " 09/01/2010 - "Sonic hedgehog signaling induces vascular smooth muscle cell proliferation via induction of the G1 cyclin-retinoblastoma axis." 01/01/2009 - "The use of conditional ABP1 defective plants reveals that the protein is essential for maintenance of the root meristem and acts at least on the D-type CYCLIN/RETINOBLASTOMA pathway to control entry into the cell cycle. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/01/2011 - "The aim of this study was to evaluate the expression of cyclins A, B1, D1 and E in advanced non-small cell lung cancer (stages IIIB-IV) with its prognostic significance. " 04/01/2011 - "We did not observe prognostic value of cyclins A, B1, D1 or E expression in advanced non-small cell lung cancer." 01/01/2011 - "The role of cell cycle protein cyclin Y (CCNY) in non-small-cell lung cancer (NSCLC) is not clear. " 01/01/2011 - "Cell cycle protein cyclin Y is associated with human non-small-cell lung cancer proliferation and tumorigenesis." 07/01/2009 - "In non-small cell lung cancer (NSCLC) cell lines, cyclins D1, D2, and E1 are directly regulated by physiologic concentrations of miR-15a/miR-16. "
4.	Multiple Myeloma 05/01/2015 - "Protein Expression for Novel Prognostic Markers (Cyclins D1, D2, D3, B1, B2, ITGβ7, FGFR3, PAX5) Correlate With Previously Reported Gene Expression Profile Patterns in Plasma Cell Myeloma." 01/01/2013 - "In this review, we focus on significance of cyclins D in multiple myeloma." 01/01/2013 - "Cyclins D are prognostic markers and are also used for subclassification of multiple myeloma. " 01/01/2013 - "It is a heterogenous disease; however, dysregulation of cyclins D seems to be an early unifying pathogenic event in multiple myeloma. " 01/01/2013 - "[Cyclins D in regulation and dysregulation of the cell cycle in multiple myeloma]."
5.	Pancreatic Neoplasms (Pancreatic Cancer) 04/01/2010 - "The aim of the present study was to compare the expression levels of the cyclins and the differentiation-related factors in pancreatic neoplasms. " 01/01/2013 - "The loss of miR-26a-mediated post-transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival." 04/15/2009 - "Thus, quiescent pancreatic cancer cells depleted of Mirk became less viable because they were damaged by ROS, and had increased levels of G(1) cyclins to prime cells to escape quiescence." 07/01/2001 - "The role of cyclins in the pathogenesis of pancreatic cancer is largely unknown. " 06/01/2005 - "Inhibition of p27Kip1 expression in Mia PaCa-2 cells restored the activity of cyclin/cdk2, phosphorylation of pRb, and E2F activity and partially relieved the effects of U0126 on pancreatic cancer cell cycle arrest. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Cyclin D1
3.	roscovitine
4.	flavopiridol
5.	Proliferating Cell Nuclear Antigen (PCNA)
6.	Messenger RNA (mRNA)
7.	NF-kappa B (NF-kB)
8.	Biological Markers (Surrogate Marker)
9.	Curcumin
10.	Metformin (Glucophage)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Chemoprevention
4.	Aftercare (After-Treatment)
5.	Transplants (Transplant)