Cyclins

A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They generally function as ENZYME ACTIVATORS that drive the CELL CYCLE through transitions between phases. A subset of cyclins may also function as transcriptional regulators.

Also Known As:

Networked: 3150 relevant articles (39 outcomes, 326 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sicinski, Piotr: 19 articles (01/2022 - 01/2002)
2.	Pestell, Richard G: 18 articles (01/2020 - 04/2002)
3.	Diehl, J Alan: 14 articles (01/2022 - 05/2002)
4.	Musgrove, Elizabeth A: 14 articles (01/2015 - 01/2002)
5.	Caldon, C Elizabeth: 13 articles (01/2022 - 02/2006)
6.	Sutherland, Robert L: 13 articles (02/2013 - 01/2002)
7.	Geng, Yan: 10 articles (01/2022 - 12/2003)
8.	Casimiro, Mathew C: 10 articles (01/2018 - 07/2006)
9.	Knudsen, Karen E: 10 articles (10/2017 - 08/2003)
10.	Knudsen, Erik S: 9 articles (01/2022 - 11/2002)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2001 - "The disease-free 5-year survival rate of patients with pRB+/cyclin D1- tumors was significantly better than that of other groups (P=0.001). " 08/13/2020 - "Low CCNE2 is associated with improved overall survival in breast cancers, and we demonstrate that low cyclin E2 protects from excess genome rereplication. " 10/16/2012 - "To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains that allow acute and global ablation of individual D-cyclins in a living animal. " 01/10/2002 - "Our results imply that the combinatorial inhibition of cyclins D1 and E might be useful in the treatment of malignancies induced by Neu." 11/01/2023 - "This review then provides a summary of current Cyclin K-associated cancer studies, with an emphasis on the available Cyclin K-targeting drugs. "
2.	Ovarian Neoplasms (Ovarian Cancer) 10/01/2016 - "While many studies have helped elucidate the functions and regulatory mechanisms of cyclin E1, further research utilizing cyclin E1 as a therapeutic target in ovarian cancer is warranted. " 10/27/2022 - "Then, we demonstrated that exosomes secreted by HO-ADSCs (HO-ADSC exosomes) enhanced ovarian cancer cell function, and further mechanistic studies showed that the FOXM1, Cyclin F, KIF20A, and MAPK signaling pathways were involved in this process. " 08/01/2016 - "This study is designated to investigate the roles of cyclin Y (CCNY) and Wnt signaling pathway in regulating ovarian cancer (OC) cell proliferation, migration, and invasion. " 01/01/2014 - "Cyclin E1 (CCNE1) as independent positive prognostic factor in advanced stage serous ovarian cancer patients - a study of the OVCAD consortium." 06/01/2010 - "This study examined the clinical significance of CCNE1 (Cyclin E1) amplification and assessed whether CCNE1 is a potential therapeutic target in ovarian cancer. "
3.	Breast Neoplasms (Breast Cancer) 08/01/2023 - "This study aimed to explore the relationship between breast cancer cells overexpressing cyclin D1b and TAMs. " 10/01/2022 - "In this study, 15 subtypes of the cyclin genes in breast cancer from public databases were selected using bioinformatics analysis, the correlation between their transcriptional expression levels and survival rates were analyzed, and the results were further confirmed using reverse transcription-quantitative PCR in vitro in various breast cancer cell lines. " 12/01/2021 - "The present study determined whether cyclin D1b contributed to the interaction between breast cancer cells and macrophages. " 12/01/2021 - "Our previous study showed that non-metastatic epithelial-like breast cancer cells were highly metastatic in vivo when cyclin D1b was overexpressed. " 10/01/2020 - "In the current study, we examined the requirement for E-type cyclins in the c-Myc-driven mouse model of breast cancer (MMTV-c-Myc mice). "
4.	Leukemia 10/01/2005 - "The major objective of the present study was to compare the levels of cyclins A, B1, D3 and E in G1 phase of the cell cycle between synchronized and unperturbed asynchronously growing human lymphocyte leukemia MOLT-4 cells. " 08/01/2003 - "This study was designed to investigate the relationship between expression of cyclins and prognosis of acute leukemia. " 10/09/2023 - "Above all, our results demonstrated that CADM1 attenuated the role of miR-1246 in promoting cell cycle progression and cell survival, thus influencing multidrug resistance within chemo-resistant leukemia cells via CDKs/Cyclins. " 10/09/2023 - "Interference with CADM1 could reduce the increased drug sensitivity induced by miR-1246 inhibition, and notably restore drug resistance by promoting cell cycle progression and cell survival via regulating CDKs/Cyclins complexes in chemo-resistant leukemia cells. " 01/01/2018 - "SETD1A Interacts with Cyclin K to Promote Leukemia Cell Survival."
5.	Neoplasm Metastasis (Metastasis) 12/01/2022 - "This study finds that by promoting the PBX3 transcription, LINC00478 can further regulate the expressions of downstream cyclins, thereby facilitating the metastasis and invasion of ccRCC." 11/26/2015 - "Taken together, these data point to this cyclin as a potential mediator of cell-niche interactions whose dysregulation could be taken as a hallmark of metastasis. " 02/20/2015 - "Harboring a cyclin amplification was not associated with overall survival, the time to metastasis/recurrence, nor with the best progression-free survival. " 03/01/2012 - "These findings demonstrate that Cyclin E2 may play important roles in the invasion, metastasis, and poor prognosis of NPC." 04/16/2009 - "In contrast, elevated cyclin D1b expression was independently associated with adverse outcomes, including recurrence, distant metastasis and decreased survival. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Cyclin D1
3.	Biomarkers (Surrogate Marker)
4.	Catenins
5.	Proteins (Proteins, Gene)
6.	Cyclin-Dependent Kinases (cdk Proteins)
7.	Cyclins
8.	Proliferating Cell Nuclear Antigen (PCNA)
9.	Survivin
10.	MicroRNAs (MicroRNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Chemoprevention
4.	Transplantation
5.	Immunotherapy