Histone Deacetylase 1

A histone deacetylase subtype that is found along with HISTONE DEACETYLASE 2; RETINOBLASTOMA-BINDING PROTEIN 4; and RETINOBLASTOMA-BINDING PROTEIN 7 as core components of histone deacetylase complexes.

Also Known As:

Networked: 122 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Shimada, Mitsuo: 4 articles (04/2015 - 01/2007)
2.	Seiser, Christian: 4 articles (12/2010 - 04/2003)
3.	Liu, Jing: 3 articles (08/2013 - 10/2007)
4.	Yoshikawa, Kozo: 2 articles (04/2015 - 08/2011)
5.	Kurita, Nobuhiro: 2 articles (04/2015 - 08/2011)
6.	Higashijima, Jun: 2 articles (04/2015 - 08/2011)
7.	Zhang, Qing: 2 articles (01/2015 - 01/2010)
8.	Robson, Craig N: 2 articles (07/2014 - 09/2006)
9.	Gaughan, Luke: 2 articles (07/2014 - 09/2006)
10.	Park, Chung S: 2 articles (06/2014 - 05/2012)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 09/01/2009 - "This study was designed to investigate the role of histone deacetylase 1 during tumorigenesis in MCF-7 human breast cancer cells. " 08/01/2012 - "Ras homolog enriched in brain (RHEB) plays an important role in cell growth and cell-cycle control, histone deacetylase 1 (HDAC1) is an important factor in breast tumor progression and prognosis, and WEE1 homolog (WEE1) functions as a tumor suppressor. " 08/01/2009 - "In further studies, BRCA1 overexpression inhibited the recruitment of coactivators (steroid receptor coactivator 1 and amplified in breast cancer 1) and enhanced the recruitment of a corepressor (histone deacetylase 1) to the c-Myc PRE, whereas BRCA1 knockdown increased the abundance of AIB1 and decreased the abundance of HDAC1 at the c-Myc PRE. " 02/04/2005 - "ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line." 11/10/2003 - "Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha."
2.	Neoplasms (Cancer) 06/01/2014 - "Pubertal supplementation of lipotropes in female rats reduces mammary cancer risk by suppressing histone deacetylase 1." 02/01/2012 - "Histone deacetylase 1 and 2 in mesenchymal tumors." 04/01/2011 - "Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer." 07/01/2007 - "Role for histone deacetylase 1 in human tumor cell proliferation." 08/01/2012 - "Ras homolog enriched in brain (RHEB) plays an important role in cell growth and cell-cycle control, histone deacetylase 1 (HDAC1) is an important factor in breast tumor progression and prognosis, and WEE1 homolog (WEE1) functions as a tumor suppressor. "
3.	Stomach Neoplasms (Stomach Cancer) 04/01/2015 - "This study investigated the correlation between cluster of differentiation 133 (CD133), histone deacetylase 1 (HDAC1) and thrombospondin-1 (THBS1) expression in advanced gastric cancer. " 08/01/2015 - "Depletion of histone deacetylase 1 inhibits metastatic abilities of gastric cancer cells by regulating the miR-34a/CD44 pathway." 04/01/2015 - "The relationship of CD133, histone deacetylase 1 and thrombospondin-1 in gastric cancer." 10/01/2011 - "Histone deacetylase 1 expression in gastric cancer." 12/01/2001 - "Expression profile of histone deacetylase 1 in gastric cancer tissues."
4.	Multiple Endocrine Neoplasia Type 1 (MEN I) 10/01/2002 - "In the present study deletions of 1p were characterized and the findings were evaluated in relation to the loci of MEN1 and histone deacetylase 1 gene (HDAC1), a menin interacting partner in 1p, as well as to the clinical characteristics. "
5.	Sialadenitis 01/01/2015 - "In this study, we examined the effects of administering EGCG to MRL-Fas(lpr) mice with autoimmune sialadenitis on the levels of AQP5, activated NF-κB p65 subunit, activated PKA, activated c-Jun N-terminal kinase (JNK) (an activator of NF-κB), inhibitor κB (IκB) and histone deacetylase 1 (HDAC1) (an inhibitor of NF-κB). "

Related Drugs and Biologics

1.	DNA methyltransferase 3A
2.	Nuclear Receptor Coactivator 1
3.	JNK Mitogen-Activated Protein Kinases
4.	Histones (Histone)
5.	DNA (Deoxyribonucleic Acid)
6.	Messenger RNA (mRNA)
7.	Chromatin
8.	Estrogen Receptor alpha
9.	Histone Deacetylases (Histone Deacetylase)
10.	Co-Repressor Proteins