Compounds based on CHALCONE. They are important intermediates in the formation of FLAVONOIDS.
Also Known As:
1,3-Diphenyl-propanediones; 1,3-Diphenyl-propenones; 1,3-Diphenylpropanediones; 1,3-Diphenylpropenones; 1,3 Diphenyl propanediones; 1,3 Diphenyl propenones; 1,3 Diphenylpropanediones; 1,3 Diphenylpropenones
Networked: 182 relevant articles (4 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Nunes, Ricardo José: 8 articles (01/2015 - 09/2008)
2. Winter, Evelyn: 6 articles (01/2015 - 05/2013)
3. Yunes, Rosendo Augusto: 6 articles (08/2014 - 12/2008)
4. Chiaradia, Louise Domeneghini: 5 articles (08/2014 - 12/2008)
5. Mascarello, Alessandra: 5 articles (01/2014 - 12/2008)
6. Di Pietro, Attilio: 4 articles (01/2015 - 04/2012)
7. Diederich, Marc: 4 articles (09/2014 - 04/2006)
8. Haratake, Mamoru: 4 articles (09/2010 - 10/2007)
9. Ono, Masahiro: 4 articles (09/2010 - 10/2007)
10. Nakayama, Morio: 4 articles (09/2010 - 10/2007)

Related Diseases

1. Neoplasms (Cancer)
2. Prostatic Neoplasms (Prostate Cancer)
3. Edema
10/15/2013 - "The aim of this study was to synthesize three nitro substituted chalcones and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. "
04/01/2011 - "Chalcones of 2a-f and their corresponding products, pyrazolines 3a-f, were synthesized and evaluated for their anti-inflammatory activity against carrageenan edema in albino rats at a dose of 10 mg/kg. All the compounds of this series showed promising anti-inflammatory activity. "
06/01/2013 - "Some unnatural chalcones (1a-q) and flavones (2a-d) have been synthesized and evaluated for their antiinflammatory activity using carrageenan-induced rat paw edema assay. "
05/01/2006 - "The synthesis of 1,3-diaryl propen-1-ones (chalcones) by the Claisen-Schmidt condensation between acetophenones and benzaldehydes in potassium hydroxide/methanol medium at room temperature yielded: 1-(4-nitrophenyl)-3-(2,4,6-trimethoxyphenyl)propen-1-one (3a), 1-(4-nitrophenyl)-3-(3-bromophenyl)propen-1one (3b), 1-(4-methoxyphenyl)-3-(3-bromophenyl)propen-1-one (3c), 1-(4-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)propen-1-one (3d), 1-(2,4-dihydroxyphenyl)-3-(phenyl)propen-1-one (3e), 1-(4-nitrophenyl)-3-(4-chlorophenyl)propen-1-one (3f) which were evaluated for anti-inflammatory activity at doses of 20, 40 and 80mg/kg. The compounds were found to be effective inhibitors of carrageenan-induced rat paw edema in Wistar rats and this activity was dose dependent and increased between the third and fourth hour. "
4. Carcinoma (Carcinomatosis)
10/01/2014 - "We synthesized racemic mixtures of these flavanones from corresponding chalcones and herein we report for the first time the molecular mechanisms of cell death, anti-proliferative effect and ability to induce apoptosis in human cervical carcinoma (HeLa) cells. "
01/01/2014 - "In this study, a group of recently synthesized chalcones, with the structure of 1,3-diarylprop-2-en-1-one having different COX-1 and/or COX-2 selectivities have been examined on human hepatocarcinoma (HepG2), lung carcinoma (A549), and breast adenocarcinoma (MCF-7) cell line, using Sulforhodamine B (SRB) assay. "
02/01/2001 - "Fourteen novel C-prenylated and O-allylated 1,3-diarylpropenones (chalcones) were synthesized by Claisen-Schmidt condensation reaction of C-prenylated/O-allylated acetophenones with appropriate aldehydes; twelve of these model chalcones were screened in an assay based on the confrontation of invasive human MCF-7/6 mammary carcinoma cells with fragments of normal embryonic chick heart in vitro. "
01/01/2012 - "Chalcones promoted 1 of the 2 steps in a rapid, convergent synthesis of a small library of hydrazinyl pyrazole derivatives, all of which exhibited significant antitumor activity against Ehrlich Ascites Carcinoma (EAC) human tumor cell line comparable to that of the natural anticancer doxorubicin, as a reference standard during this study. "
05/15/2007 - "A series of synthetic chalcones, flavanones, and flavones has been synthesized and evaluated for antitumor activity against the human kidney carcinoma cells TK-10, human mammary adenocarcinoma cells MCF-7 (estrogen receptor-positive), and human colon adenocarcinoma cells HT-29. "
5. Inflammation

Related Drugs and Biologics

1. Acetophenones
2. Carrageenan
3. P-Glycoprotein
4. Tubulin
5. Oxidoreductases
6. Type II DNA Topoisomerases (Topoisomerase II)
7. Cathepsin K
8. Proteasome Endopeptidase Complex (Proteasome)
9. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10. Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)

Related Therapies and Procedures

1. Chemoprevention
2. Traditional Medicine (Folk Remedies)
3. Drug Therapy (Chemotherapy)
4. Radiotherapy