Tubulin

A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.

Also Known As:

Networked: 2450 relevant articles (49 outcomes, 262 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hamel, Ernest: 38 articles (08/2015 - 10/2002)
2.	Dumontet, Charles: 21 articles (10/2012 - 12/2002)
3.	Kavallaris, Maria: 18 articles (02/2015 - 09/2002)
4.	Panda, Dulal: 17 articles (11/2015 - 10/2002)
5.	Ferlini, Cristiano: 16 articles (06/2015 - 01/2005)
6.	Katsetos, Christos D: 15 articles (07/2015 - 04/2002)
7.	Brancale, Andrea: 13 articles (08/2015 - 12/2004)
8.	Romagnoli, Romeo: 12 articles (04/2015 - 05/2007)
9.	Scambia, Giovanni: 12 articles (06/2014 - 01/2005)
10.	Jordan, Mary Ann: 11 articles (11/2015 - 05/2004)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2007 - "BM6, a new semi-synthetic vinca alkaloid, exhibits its potent in vivo anti-tumor activities via its high binding affinity for tubulin and improved pharmacokinetic profiles." 05/03/2004 - "Compounds inhibited tubulin polymerization with potencies commensurate with their cytotoxic activity and a more soluble anilino-containing analogue was very effective in inhibiting the growth of AR42J rat pancreatic tumors transplanted into in nude mice. " 02/01/2012 - "In tumors of treated animals, a significant reduction of Ki67, which was negatively correlated with tubulin acetylation, was observed. " 02/01/2001 - "Vascular targeting of solid tumors, using tubulin-compromising agents, seems a promising and selective novel treatment. " 10/20/2015 - "Furthermore, in silico docking studies of compounds 2l, 2e and 2h within the active site of tubulin were carried out in order to rationalize the mechanism of the anti-cancer properties of these compounds. "
2.	Breast Neoplasms (Breast Cancer) 02/01/2012 - "Measuring β-tubulin III, Bcl-2, and ERCC1 improves pathological complete remission predictive accuracy in breast cancer." 02/01/2015 - "NAC-TC may be especially effective in ER-breast cancer with low class III β tubulin or non-basal TNBC." 01/01/2015 - "In this study, we report that elevated levels of α-tubulin acetylation are a sufficient cause of metastatic potential in breast cancer. " 02/15/2014 - "In this study, we report that breast cancer cell lines with more stem-like properties display higher levels of microtentacles (McTN), a type of tubulin-based protrusion of the plasma cell membrane that forms on detached or suspended cells and aid in cell reattachment. " 01/01/2014 - "Mechanistic studies reveal that γ-tubulin interacts with and recruits Mdp3 to the centrosome and that the centrosomal localization of Mdp3 is required for its activity to promote breast cancer cell proliferation and motility. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/21/2012 - "Tubulin-binding agents (TBAs) are effective in non-small cell lung cancer (NSCLC) treatment. " 06/01/2015 - "The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1." 01/15/2015 - "βIII-tubulin (encoded by TUBB3) expression is associated with therapeutic resistance and aggressive disease in non-small cell lung cancer (NSCLC), but the basis for its pathogenic influence is not understood. " 01/15/2015 - "TUBB3/βIII-tubulin acts through the PTEN/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer." 08/20/2014 - "Increased expression of βIII-tubulin has been implicated in non-small cell lung cancer (NSCLC) cell lines. "
4.	Infection 05/01/2015 - "These positive findings, showing absence of elevated frequencies of BZ-resistance-associated β-tubulin alleles, have considerable significance since it suggests that farmers can still rely on the efficacy of this important drug class when used for controlling trichostrongyle infections in cattle in Nigeria. " 01/25/2008 - "Thus, the immunization of goldfish with recombinant parasite beta-tubulin conferred partial antibody-mediated protection against a challenge infection with live trypanosomes. " 01/25/2008 - "Administration of recombinant parasite beta-tubulin to goldfish (Carassius auratus L.) confers partial protection against challenge infection with Trypanosoma danilewskyi Laveran and Mesnil, 1904." 05/01/2004 - "In this study, we investigated the role of actin and tubulin in productive MV infection by inducing disassembly of the microfilaments and microtubules. " 01/01/2015 - "Moreover, H5N1 infection did not appear to alter expression of neuronal and astrocytic markers of hNPCs, such as β-III tubulin and GFAP, respectively. "
5.	Carcinoma (Carcinomatosis) 04/01/2014 - "Our study aims to investigate the expressions of β-tubulin isotypes and their significances in urothelial carcinoma of the bladder (UCB) as altered expression of a specific β-tubulin isotype is associated with chemoresistance and poor prognosis in other malignancies. " 02/01/2011 - "Based on this, we have demonstrated in this study that patients with a high expression of the miR-200 family show low levels of β-tubulin class III in ovarian carcinoma. " 01/01/2015 - "[BETA-III TUBULIN AS A POTENTIAL TARGET FOR BLOCKING INVASIVE GROWTH OF MALIGNANT EPITHELIAL TUMORS]." 11/24/2014 - "Moreover, the compounds induced G2/M phase arrest in human cervical carcinoma HeLa cells as reported for tubulin depolymerizing agents." 04/01/2014 - "Expression of β-tubulin isotypes in urothelial carcinoma of the bladder."

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	P-Glycoprotein
3.	Proteins (Proteins, Gene)
4.	taxane
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	benzimidazole
7.	Vinca Alkaloids
8.	Prodrugs
9.	docetaxel (Taxotere)
10.	Colchicine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Laser Therapy (Surgery, Laser)
4.	Adjuvant Chemotherapy
5.	Aftercare (After-Treatment)