Synthesis and anti-inflammatory activity of three nitro chalcones.

Abstract

The aim of this study was to synthesize three nitro substituted chalcones and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. The nitro chalcone were prepared by aldol condensation using of mechanical agitation and environmentally friendly solvents with 72-73% yields in approximately 2h. The three structures were evaluated on biological activity at dose of 200mg/kg and they showed anti-inflammatory protective effect by both oral and intraperitoneal administration, this effect was time dependent.

• Authors: Abraham Gómez-Rivera, Hidemí Aguilar-Mariscal, Nancy Romero-Ceronio, Luis F Roa-de la Fuente, Carlos E Lobato-García
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 23 Issue 20 Pg. 5519-22 (Oct 15 2013) ISSN: 1464-3405 [Electronic] England
• PMID: 24012185 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Chalcone

Topics

• Administration, Oral
• Animals
• Anti-Inflammatory Agents (chemical synthesis, chemistry, therapeutic use)
• Area Under Curve
• Chalcone (chemical synthesis, chemistry, therapeutic use)
• Disease Models, Animal
• Edema (chemically induced, drug therapy)
• ROC Curve
• Rats