Membrane Transport Proteins (Biological Pump)

Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.

Also Known As:

Biological Pump; Permeases; Pump, Biological; Biological Pumps; Metabolic Pumps; Pump, Biologic; Pump, Metabolic; Pumps, Biological; Pumps, Metabolic; Biologic Pump; Protein, Membrane Transport; Transport Protein, Membrane; Transport Proteins, Membrane; Transporter, Membrane; Transporters, Membrane; Membrane Transport Protein; Membrane Transporter; Membrane Transporters; Metabolic Pump; Permease

Networked: 606 relevant articles (11 outcomes, 43 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - Membrane Transport Proteins: 606
  - Membrane Proteins: 10262
    - Membrane Transport Proteins: 606

Experts

1.	Tang, Wei: 7 articles (12/2021 - 10/2014)
2.	Lewis, David A: 7 articles (01/2017 - 10/2002)
3.	Jiang, Li: 6 articles (12/2021 - 10/2014)
4.	Huang, Ying: 5 articles (04/2009 - 06/2004)
5.	Kosuga, Toshiyuki: 4 articles (12/2023 - 09/2021)
6.	Kudou, Michihiro: 4 articles (12/2023 - 09/2021)
7.	Otsuji, Eigo: 4 articles (12/2023 - 09/2021)
8.	Shimizu, Hiroki: 4 articles (12/2023 - 09/2021)
9.	Shiozaki, Atsushi: 4 articles (12/2023 - 09/2021)
10.	Chen, Jing: 4 articles (11/2023 - 07/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "In addition, the role of membrane transporters in PTT will be highlighted and different methods of transporter modulation will be summarized from several PTT studies in which multifunctional NPs were used to treat cancers in vitro and in vivo." 02/05/2024 - "Water cycling across the membrane transporters is considered a hallmark of cellular metabolism and it could be of high diagnostic relevance in the characterization of tumors and other diseases. " 12/01/2023 - "The potential of membrane transporters activated in cancer stem cells (CSCs) as new therapeutic targets for cancer is attracting increasing interest. " 11/01/2023 - "Membrane transporters in cell physiology, cancer metabolism and drug response." 04/12/2023 - "Relevant Membrane Transport Proteins as Possible Gatekeepers for Effective Pharmacological Ascorbate Treatment in Cancer."
2.	Breast Neoplasms (Breast Cancer) 09/01/2021 - "Mechanisms which contribute to multidrug resistance of breast cancer cells to PTX include the active removal of the drug from the cell related to the increased activity of ABC family membrane transporters. " 06/01/2010 - "The expression of the membrane transporters MCT1 and MCT4 was analysed in a series of breast carcinomas (249 cases) and their clinicopathological significance investigated. " 10/01/2007 - "The adenotriphosphate-binding cassette membrane transporter family contributes to clinical drug resistance, especially in breast cancer. " 01/01/2018 - "Associations between genetic polymorphisms of membrane transporter genes and prognosis after chemotherapy: meta-analysis and finding from Seoul Breast Cancer Study (SEBCS)." 03/02/2016 - "SALL4 knockdown inhibits the growth of the drug resistant breast cancer due to cell cycle arrest and reverses tumor chemo-resistance through down-regulating the membrane transporter, BCPR. "
3.	Cardiovascular Diseases (Cardiovascular Disease) 07/01/2015 - "The membrane transporter ABCA1 is a key player in cholesterol efflux from macrophages and has been shown via human genetic studies to provide protection against cardiovascular disease. " 01/07/2024 - "The aim of our study was to investigate the levels of plasma and platelet serotonin, 5-hydroxyindoleacetic acid, and membrane transporter in a cross-sectional study of two pediatric groups, including patients with familial hypercholesterolemia and the control group, which consisted of apparently healthy children without cardiovascular diseases. " 03/01/2007 - "Several research groups concentrate on drugs used to treat specific medical disorders (asthma, depression, cardiovascular disease, addiction of nicotine, and cancer), whereas others are focused on specific groups of proteins that interact with drugs (membrane transporters and phase II drug-metabolizing enzymes). " 05/05/2011 - "A major obstacle to using bone marrow cell-based therapies for ischemic cardiovascular disease is that transplanted cells must survive in an ischemic microenvironment characterized by low oxygen, glucose, and pH. We demonstrate that treatment of bone marrow-derived angiogenic cells (BMDACs) with dimethyloxalylglycine, an α-ketoglutarate antagonist that induces hypoxia-inducible factor 1 (HIF-1) activity, results in metabolic reprogramming of these cells, with increased glucose uptake, decreased O(2) consumption, increased lactate production, decreased reactive oxygen species, and increased intracellular pH. These effects are dependent on HIF-1, which transactivates target genes encoding metabolic enzymes and membrane transporters. "
4.	Chronic Pain 11/30/2002 - "Intrathecal grafting of cells as biological pumps to deliver monoamines, endorphins, and/or trophic factors, has been shown to be effective in treating chronic pain both in experimental animals and in clinical trials. "
5.	Pulmonary Edema 05/01/2013 - "Studies with hamsters demonstrated that in leptospirosis a noncardiogenic pulmonary edema occurs consequently to a decrease in the clearance of alveolar fluid, due to a decrease in sodium transporter in the luminal membrane (ENaC) and an increase in the NKCC1 basolateral membrane transporter. "

Related Drugs and Biologics

1.	Membrane Transport Proteins (Biological Pump)
2.	Cholesterol
3.	Proteins (Proteins, Gene)
4.	Adenosine Triphosphate (ATP)
5.	Phenobarbital (Luminal)
6.	Sodium
7.	Endorphins
8.	ATP-Binding Cassette Transporters (ABC Transporters)
9.	Bile Acids and Salts (Bile Acids)
10.	Phospholipids (Phosphatides)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Photothermal Therapy
4.	Quantum Dots (Quantum Dot)
5.	Continuous Ambulatory Peritoneal Dialysis (CAPD)