Endorphins

One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.

Also Known As:

Networked: 670 relevant articles (22 outcomes, 66 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Csaba, György: 7 articles (09/2014 - 03/2004)
2.	Gong, Nian: 4 articles (02/2016 - 04/2014)
3.	Wang, Yong-Xiang: 4 articles (02/2016 - 04/2014)
4.	Sinchak, Kevin: 4 articles (01/2015 - 11/2011)
5.	Pállinger, Eva: 4 articles (01/2009 - 07/2006)
6.	Li, Teng-Fei: 3 articles (02/2016 - 01/2015)
7.	Fan, Hui: 3 articles (02/2016 - 04/2014)
8.	Zhang, Changqing: 3 articles (01/2013 - 10/2011)
9.	Sarkar, Dipak K: 3 articles (01/2013 - 10/2011)
10.	Csaba, G: 3 articles (09/2007 - 01/2004)

Related Diseases

1.	Pain (Aches) 02/04/1984 - "Pain relief from cryohypophysectomy is surmised to be due to the production of endorphins, but no proof of this is available." 01/01/2011 - "In this study, we determined the role of peripheral CB2Rs in the effects of EA on the expression of β-endorphin in inflamed skin tissues and inflammatory pain. " 01/01/2002 - "Previous studies established the increased output of messengers at neuronal junctions in spinal cord and hypothalamic locations, especially of endorphins which inhibit the perception of pain. " 01/01/2000 - "The aim of this study, therefore, was to determine whether the levels of β-endorphin in PBMC of patients with complex regional pain syndrome (CRPS) differ from those of healthy subjects. " 01/01/1985 - "Confirming our earlier studies, the therapy induced changes in pain measures showed a significant, positive correlation with increasing Fraction I endorphins in CSF. "
2.	Respiratory Insufficiency (Respiratory Failure) 04/01/1982 - "Hypoxic ventilatory depression appears not to be mediated by endorphins in adults." 03/27/1982 - "These findings suggest that in acute respiratory failure there may be overproduction of, or increased sensitivity to, endorphins." 07/01/1990 - "Naloxone, an endorphin antagonist, is widely used for the reversal of narcotic-induced respiratory depression but has not been shown to be clinically effective for either severely or moderately asphyxiated infants. " 08/01/1987 - "We conclude that endorphins play a role in septic ventilatory depression and that naloxone is effective in ameliorating it." 11/01/1983 - "We hypothesized that this ventilatory depression, like some other central nervous system effects of ethanol, might be mediated via endorphins. "
3.	Schizophrenia (Dementia Praecox) 08/01/1992 - "The lack of efficacy of DE-gamma-E suggests that the theories that the endorphins have an important role in schizophrenia have to be revised. " 01/01/1986 - "The present study does not support the hypothesis of dysfunction of the endorphin system in schizophrenia." 01/01/1981 - "Clinical studies on the role of endorphins in schizophrenia." 01/01/1981 - "On the basis of the hypothesis that hyperactivity of endorphin systems may be involved in the pathogenesis of schizophrenia and manic syndromes, the effect of opiate antagonists on psychotic and manic symptoms has been examined in a number of clinical studies in the past few years. " 01/01/1981 - "This attempt refers to studies which confirm any role of endorphins in the origin of schizophrenia. "
4.	Shock 02/01/1986 - "In this study, both drugs were given concurrently during shock to evaluate hemodynamic changes, plasma endorphin-like activity (PELA), and survival. " 05/01/1988 - "Endorphins in circulatory shock." 05/01/1988 - "Evidence for a role of endorphins in the cardiovascular pathophysiology of primate shock." 01/01/1986 - "The ulcerogenic effect of endotoxin shock is apparently mediated through the release of endorphins." 08/01/1985 - "The role of endorphins in septicaemic shock: a pilot study in burned patients."
5.	Migraine Disorders (Migraine) 04/01/2013 - "The improvement in migraine after rTMS was associated with increase in β endorphin level." 04/01/2013 - "It can be concluded from this study that the basal plasma β endorphin level was low in migraine patients, especially in chronic migraine. " 08/24/1983 - "This study was planned as a pilot study to determine to what extent acupuncture might help in severe cases of migraine and, if possible, to see whether the mechanism was endorphin mediated. " 04/01/2013 - "β endorphin level was lower in chronic compared to episodic migraine (3.74 ± 2.20 versus 5.65 ± 2.02 ng/ml). " 04/01/2013 - "β endorphin level was significantly lower in migraine (4.35 ± 2.29 ng/ml) compared to controls (6.68 ± 2.93 ng/ml). "

Related Drugs and Biologics

1.	Endorphins
2.	Naloxone (Narcan)
3.	Opioid Peptides (Opioid Peptide)
4.	Opioid Receptors (Opioid Receptor)
5.	Enkephalins
6.	Opioid Analgesics (Opioids)
7.	Neurotransmitter Agents (Neurotransmitter)
8.	Insulin (Novolin)
9.	Pro-Opiomelanocortin (Proopiomelanocortin)
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Transcutaneous Electric Nerve Stimulation (TENS)
2.	Analgesia
3.	Renal Dialysis (Hemodialysis)
4.	Acupuncture Points (Acupuncture Point)
5.	Balloon Occlusion