Connexins

A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.

Also Known As:

Networked: 825 relevant articles (6 outcomes, 83 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mesnil, Marc: 14 articles (07/2015 - 11/2002)
2.	Kwak, Brenda R: 14 articles (04/2014 - 02/2002)
3.	Naus, Christian C: 13 articles (11/2015 - 01/2007)
4.	Scherer, Steven S: 10 articles (08/2015 - 10/2002)
5.	Willecke, Klaus: 10 articles (05/2014 - 05/2002)
6.	Spray, David C: 10 articles (01/2011 - 05/2002)
7.	Laird, Dale W: 9 articles (11/2015 - 08/2002)
8.	Bechberger, John F: 8 articles (11/2015 - 06/2002)
9.	White, Thomas W: 8 articles (09/2015 - 06/2003)
10.	Crespin, Sophie: 8 articles (05/2014 - 12/2005)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2000 - "Therefore, analysis of gap junction protein may be helpful for the differential diagnosis of benign and malignant adrenal tumors. " 01/01/2010 - "An intracellular location of connexins, the site of their common and the most frequent detection within cancer cells in our study may be of significance. " 02/08/2007 - "In the present study, using reverse transcription-polymerase chain reaction (RT-PCR) and in situ RT-PCR, we examined expression of Connexins (Cx26, 32, 37, 40, 43 and 45) in the normal lung and lung tumors of mice to determine whether their expressions change during lung tumorigenesis. " 12/01/2006 - "In support of this hypothesis are studies showing that reexpression of connexins in cancer cells causes normalization of cell growth control and reduced tumor growth. " 01/01/2006 - "These studies indicate that connexins have unique properties that contribute to their tumor suppressive function."
2.	Atrial Fibrillation 12/01/2015 - "We have previously shown that right-sided low-level tragus nerve stimulation (LL-TS) is an effective approach for the treatment of atrial fibrillation (AF) induced by rapid atrial pacing (RAP) and acts by preventing the loss of atrial connexins (Cxs). " 01/20/2015 - "Low level tragus nerve stimulation is a non-invasive approach for anti-atrial fibrillation via preventing the loss of connexins." 11/01/2014 - "The remodeling of myocyte connections and altered electrical conduction associated with atrial fibrillation (AF) likely involves perturbations of these connexins. " 01/01/2014 - "Mutations in GJA5 encoding the gap junction protein connexin40 (Cx40) have been linked to lone atrial fibrillation. " 12/01/2012 - "Alteration of cardiomyocyte gap-junctions and component connexins (Cx) has been suggested to contribute to the development of atrial fibrillation (AF), including postoperative AF. "
3.	Neuroblastoma 12/01/2006 - "Here, we used the dual whole-cell patch-clamp method to study the actions of 2-APB on gap junction channels formed by selected connexins expressed in a communication-deficient neuroblastoma cell line (N2A). " 11/15/2000 - "Transient functional expression in paired Xenopus oocytes and in the neuroblastoma N2A cell line indicate an extreme range of electrophysiological properties of these connexins in terms of voltage dependence and unitary conductance. " 06/01/2003 - "We determined the effect of flufenamic acid (FFA) and related derivatives on gap junction channel currents, applying the dual whole-cell patch-clamp technique to pairs of N2A neuroblastoma cells transfected with various connexins. " 04/01/2000 - "To further investigate the mechanism underlying cell death mediated by HSV-tk and to evaluate the efficacy of gap junction channels formed by different connexins in this process, we have stably transfected a virtually uncoupled mouse neuroblastoma cell line (N2A cells) with different connexin-types expressed by neural cells (Cx32, Cx37, Cx40, Cx43) and co-cultured these cells with N2A cells stably transfected with Cx37 and HSV-tk. " 05/01/2003 - "To regulate the expression of connexins in cells, plasmids encoding a transactivator and/or a lac-operon IPTG response-dependent Cx43 target gene were transfected into communication-deficient N2a neuroblastoma cells. "
4.	Pain (Aches) 01/01/2013 - "Connexins represent a novel, peripheral target for the treatment of chronic pain and dermatological disease." 02/01/2012 - "The involvement of dorsal root ganglia and spinal cord gap junctions in mediating chronic pain and the potential for targeting connexins as a novel modality for the treatment of intractable pain syndromes arising from nervous system injury and disorders are discussed." 01/30/2013 - "Gap junction protein connexin43 (Cx43) specific antisense oligodeoxynucleotides (AsODN) have been shown to improve a number of inflammatory conditions and may therefore offer a novel strategy for persistent pain management. "
5.	Ciguatera Poisoning (Ciguatera) 06/01/2013 - "The activation of astroglia was further indicated by activation of the gap junction protein connexin 43 and upregulation of excitatory amino acid transporter 2 expression suggesting that glutamate was normally rapidly cleared from the synaptic cleft during acute ciguatera poisoning. "

Related Drugs and Biologics

1.	Connexin 43 (Connexin43)
2.	Cadherins (E-Cadherin)
3.	Glutamic Acid (Glutamate)
4.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)
5.	Carbon Monoxide
6.	Oligodeoxyribonucleotides
7.	Excitatory Amino Acid Transporter 2
8.	involucrin
9.	Connexins
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Ligation
2.	Lasers (Laser)
3.	Chemoprevention
4.	Drug Therapy (Chemotherapy)
5.	Cochlear Implants (Cochlear Implant)