Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development.

Abstract

Breast cancer is the most common malignancy among women and has an age-specific incidence profile. Over the last decade, many studies have demonstrated the anticancer activity of α-tocopherol, the main and most active form of natural vitamin E. α-Tocopherol-associated protein (TAP) was found to be one of the major α-tocopherol binding proteins in human serum and in liver, brain, and prostate tissues. In this study, we found that reduced TAP expression was significantly correlated with Her2/neu receptor expression, breast cancer stage and nodal stage in paired normal and cancerous breast tissue samples from 93 patients using real-time PCR analysis. A cell viability assay showed that α-tocopheryl succinate (α-TOS), a synthetic derivative of α-tocopherol, enhanced the cells' sensitivity to doxorubicin and resulted in a reduction in cell viability in breast cancers. Taken together, these data suggest that the use of vitamin E or its analogue as a dietary supplement may be beneficial for the treatment of cancer.

• Authors: Ka-Wai Tam, Chi-Tang Ho, Wen-Jui Lee, Shih-Hsin Tu, Ching-Shui Huang, Ching-Shyang Chen, Chia-Hwa Lee, Chih-Hsiung Wu, Yuan-Soon Ho
• Journal: Food chemistry (Food Chem) Vol. 138 Issue 2-3 Pg. 1015-21 (Jun 01 2013) ISSN: 1873-7072 [Electronic] England
• PMID: 23411208 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Carrier Proteins
• Lipoproteins
• SEC14L2 protein, human
• Trans-Activators
• Vitamin E
• Receptor, ErbB-2
• alpha-Tocopherol

Topics

• Breast Neoplasms (drug therapy, genetics, metabolism, pathology)
• Carrier Proteins (genetics, metabolism)
• Cell Line, Tumor
• Dietary Supplements (analysis)
• Disease Progression
• Epithelial Cells (metabolism)
• Female
• Humans
• Lipoproteins (genetics, metabolism)
• Receptor, ErbB-2 (genetics, metabolism)
• Trans-Activators (genetics, metabolism)
• Vitamin E (administration & dosage)
• alpha-Tocopherol (administration & dosage)