HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Vitamin E reduces progression of atherosclerosis in low-density lipoprotein receptor-deficient mice with established vascular lesions.

AbstractBACKGROUND:
A growing body of evidence from animal studies supports the hypothesis that oxidative stress-mediated mechanisms play a central role in early atherogenesis. In contrast, clinical trials with antioxidant vitamins have not produced consistent results in humans with established atherosclerosis.
METHODS AND RESULTS:
Low-density lipoprotein receptor-deficient mice (LDLR KO) were fed a high-fat diet for 3 months to induce atheroma. At this time, 1 group of mice was euthanized for examination of atherosclerosis, and 2 other groups were randomized to receive high-fat diet either alone or supplemented with vitamin E for 3 additional months. At the end of the study, LDLR KO on a vitamin E-supplemented fat diet had decreased 8,12-iso-isoprostane (iP)F(2alpha)-VI and monocyte chemoattractant protein-1 levels, but increased nitric oxide levels compared with mice on placebo. No difference in lipid levels was observed between the 2 groups. Compared with baseline, placebo group had progression of atherosclerosis. In contrast, vitamin E-treated animals showed a significant reduction in progression of atherosclerosis.
CONCLUSIONS:
These results demonstrate that in LDLR KO, vitamin E supplementation reduces progression of established atherosclerosis by suppressing oxidative and inflammatory reactions and increasing nitric oxide levels.
AuthorsTillmann Cyrus, Yuemang Yao, Joshua Rokach, Lina X Tang, Domenico Praticò
JournalCirculation (Circulation) Vol. 107 Issue 4 Pg. 521-3 (Feb 04 2003) ISSN: 1524-4539 [Electronic] United States
PMID12566360 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 8,12-iso-isoprostane F2alpha-VI
  • Biomarkers
  • Dietary Fats
  • Receptors, LDL
  • Triglycerides
  • Vitamin E
  • Nitric Oxide
  • Cholesterol
  • Dinoprost
Topics
  • Animals
  • Aorta (drug effects, pathology)
  • Arteriosclerosis (drug therapy, pathology)
  • Biomarkers (blood)
  • Cholesterol (blood)
  • Dietary Fats (adverse effects)
  • Dietary Supplements
  • Dinoprost (analogs & derivatives, blood)
  • Disease Progression
  • Immunohistochemistry
  • Lipid Peroxidation (drug effects)
  • Mice
  • Mice, Knockout
  • Nitric Oxide (metabolism)
  • Receptors, LDL (deficiency, genetics)
  • Treatment Outcome
  • Triglycerides (blood)
  • Vitamin E (blood, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: