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Tetracaine (Amethocaine)

A potent local anesthetic of the ester type used for surface and spinal anesthesia.

Also Known As:

Amethocaine; Ametop; Dicaine; Pantocaine; Pontocaine; Smith and Nephew Brand of Tetracaine HCl; Tetracaine Monohydrochloride; Tetrakain; Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester

Networked: 386 relevant articles (46 outcomes, 65 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Taddio, Anna: 7 articles (12/2009 - 04/2002)
2.	Radnovich, Richard: 5 articles (07/2015 - 01/2013)
3.	Koren, Gideon: 5 articles (12/2009 - 04/2002)
4.	Gammaitoni, Arnold R: 4 articles (07/2015 - 01/2013)
5.	Galer, Bradley S: 3 articles (07/2015 - 01/2013)
6.	O'Brien, Lisa: 3 articles (12/2009 - 12/2004)
7.	Trudeau, Jeremiah J: 2 articles (07/2015 - 04/2015)
8.	Jensen, Mark P: 2 articles (07/2015 - 04/2015)
9.	Cohen, Joel L: 2 articles (10/2014 - 09/2013)
10.	Marriott, Thomas: 2 articles (09/2014 - 09/2013)

Related Diseases

1.	Pain (Aches) 01/01/2006 - "Tetracaine 4% when applied for 30 minutes was not beneficial in decreasing procedural pain associated with a PICC in very small infants." 12/01/2009 - "Topical tetracaine was not associated with a significant reduction in pain score, although it did lead to faster recovery times. " 01/01/2005 - "In summary, the novel preparation of 4% amethocaine gel has been shown to be clinically effective for managing pain associated with minor cutaneous procedures while maintaining a good tolerability profile. " 04/01/2000 - "However, Ametop gel was more effective, with a statistically significant difference in the pain scores of the two groups (p < 0.05)." 01/01/2006 - "The objective of this trial was to assess the safety and efficacy of tetracaine gel on the pain response of very low birth weight (VLBW) infants during insertion of a PICC. "
2.	Lacerations 11/01/1996 - "Injection 2 was given on the opposite side of the laceration after topical application of a study solution that was 4 mL of either tetracaine or normal saline. " 12/01/1990 - "The tetracaine component of TAC is superfluous for obtaining topical anesthesia of minor dermal lacerations of the face in children. " 11/01/1991 - "The investigators hypothesized that there are no measurable plasma cocaine or tetracaine levels after application of TAC in a swine laceration model. " 05/01/1990 - "The combination of tetracaine, adrenalin, and cocaine (TAC) has become increasingly popular as a topical anesthetic for the suturing of simple skin lacerations. " 10/01/1988 - "A maximal dosage of 3 ml of TAC (containing 175 mg cocaine and 7.5 mg tetracaine) was applied to each laceration. "
3.	Wounds and Injuries (Trauma) 01/01/2009 - "Management of Ocular Trauma in Emergency (MOTE) Trial: A pilot randomized double-blinded trial comparing topical amethocaine with saline in the outpatient management of corneal trauma." 01/01/1953 - "[Injuries caused by pantocaine administration]." 04/01/2008 - "Complete removal of the corneal epithelium is an essential component of riboflavin-UVA crosslinking therapy as superficial epithelial trauma and tetracaine administration alone are not sufficient to permit the penetration of riboflavin into the corneal stroma. " 04/01/2008 - "The spectra of riboflavin-treated corneas with no epithelial trauma but tetracaine administration and those with superficial epithelial trauma did not differ from those of the non-riboflavin-treated controls. " 04/01/2008 - "The corneal surface of 6 tetracaine-treated eyes, 6 eyes with superficial epithelial trauma, and 6 eyes with a fully removed epithelium was exposed to UVA light for 30 minutes during riboflavin administration. "
4.	Strabismus (Squint) 01/01/1993 - "We advocate that either could be used routinely in strabismus surgery although topical amethocaine is easier to administer." 05/01/1991 - "Topical amethocaine in strabismus surgery." 05/01/1991 - "A randomized study was performed to assess the effect of topical 1% amethocaine hydrochloride on postoperative analgesia requirements after strabismus surgery. " 06/01/2007 - "Postoperative strabismus surgery pain was improved by the use of preoperative, and pre- and postoperative, tetracaine drops. " 07/01/2003 - "Comparison of lidocaine 2% gel versus amethocaine as the sole anesthetic agent for strabismus surgery."
5.	Cataract (Cataracts) 09/01/2003 - "in addition to intracameral anaesthesia, drop anaesthesia with tetracaine drops has been established for topical anaesthesia in cataract surgery. " 01/01/2009 - "To compare the clinical efficacy of lidocaine 2% with tetracaine 0.5% for cataract surgery. " 03/01/2010 - "Consecutive patients with age-related cataract having phacoemulsification under topical anesthesia (tetracaine 0.5%) were enrolled in a prospective double-blind randomized placebo-controlled study. " 01/01/2007 - "Tetracaine hydrochloride 0.5% versus lidocaine 2% jelly as a topical anesthetic agent in cataract surgery: comparative clinical trial." 09/01/2003 - "[Tetracaine drops versus lidocaine gel for topical anaesthesia in cataract surgery]."

Related Drugs and Biologics

1.	Lidocaine (Xylocaine)
2.	Epinephrine (Adrenaline)
3.	Tetracaine (Amethocaine)
4.	Cocaine (Cocaine HCl)
5.	EMLA
6.	Bupivacaine (Bupivacaine Hydrochloride)
7.	Prilocaine (Citanest)
8.	Tissue Adhesives (Tissue Adhesive)
9.	Menthol
10.	Benzocaine (Americaine)

Related Therapies and Procedures

1.	Anesthesia
2.	Catheters
3.	Photochemotherapy (Photodynamic Therapy)
4.	Sutures (Suture)
5.	Photorefractive Keratectomy