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Cocaine (Cocaine HCl)

An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Also Known As:
Cocaine HCl; Cocaine Hydrochloride; HCl, Cocaine; Hydrochloride, Cocaine; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-
Networked: 10317 relevant articles (331 outcomes, 1364 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Gelernter, Joel: 47 articles (01/2021 - 04/2002)
2. Kranzler, Henry R: 43 articles (01/2021 - 07/2003)
3. Kosten, Thomas R: 36 articles (01/2021 - 01/2002)
4. Sinha, Rajita: 32 articles (01/2019 - 03/2005)
5. Volkow, Nora D: 31 articles (02/2022 - 04/2003)
6. Brady, Kathleen T: 29 articles (09/2022 - 01/2002)
7. Potenza, Marc N: 28 articles (09/2021 - 10/2004)
8. Kreek, Mary Jeanne: 27 articles (02/2022 - 10/2002)
9. Schmitz, Joy M: 27 articles (12/2021 - 07/2004)
10. Petry, Nancy M: 27 articles (12/2017 - 01/2003)

Related Diseases

1. Cocaine-Related Disorders (Cocaine Addiction)
2. Substance-Related Disorders (Drug Abuse)
3. Alcoholism (Alcohol Abuse)
4. Opioid-Related Disorders (Opiate Addiction)
5. Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)

Related Drugs and Biologics

1. Nicotine
2. Amphetamine (Amfetamine)
3. Methadone (Dolophine)
4. Heroin (Diamorphine)
5. Opiate Alkaloids
6. Opioid Analgesics (Opioids)
7. Epinephrine (Adrenaline)
8. Tetracaine (Amethocaine)
9. Methamphetamine (Desoxyn)
10. Disulfiram (Antabuse)

Related Therapies and Procedures

1. Therapeutics
2. Self Administration (Administration, Self)
3. Drug Therapy (Chemotherapy)
4. Injections
5. Acupuncture Therapy