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Tetracaine (ametop) compared to placebo for reducing pain associated with intramuscular injection of palivizumab (synagis).

Abstract
Infants receive many painful immunizations before they are 2 years old. The purpose of this study was to evaluate if topical tetracaine reduces the pain of intramuscular palivizumab compared to placebo. There were two study injections, one with tetracaine and one with placebo. Pain was scored by their parents and a pediatric nurse. Topical tetracaine was not associated with a significant reduction in pain score, although it did lead to faster recovery times. Additional pain-reduction strategies are required.
AuthorsBrandi D Newby, Gwen D Faschoway, Cheryl I Soukoroff
JournalJournal of pediatric nursing (J Pediatr Nurs) Vol. 24 Issue 6 Pg. 529-33 (Dec 2009) ISSN: 1532-8449 [Electronic] United States
PMID19931151 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Anesthetics, Local
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antiviral Agents
  • Tetracaine
  • Palivizumab
Topics
  • Administration, Cutaneous
  • Anesthetics, Local (therapeutic use)
  • Antibodies, Monoclonal (adverse effects)
  • Antibodies, Monoclonal, Humanized
  • Antiviral Agents (adverse effects)
  • British Columbia
  • Child, Preschool
  • Double-Blind Method
  • Female
  • Humans
  • Infant
  • Injections, Intramuscular (adverse effects)
  • Male
  • Pain (diagnosis, etiology, prevention & control)
  • Pain Measurement
  • Palivizumab
  • Parents (psychology)
  • Pilot Projects
  • Respiratory Syncytial Virus Infections (prevention & control)
  • Statistics, Nonparametric
  • Tetracaine (therapeutic use)
  • Treatment Outcome
  • Videotape Recording

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