Pepsinogens

Proenzymes secreted by chief cells, mucous neck cells, and pyloric gland cells, which are converted into pepsin in the presence of gastric acid or pepsin itself. (Dorland, 28th ed) In humans there are 2 related pepsinogen systems: PEPSINOGEN A (formerly pepsinogen I or pepsinogen) and PEPSINOGEN C (formerly pepsinogen II or progastricsin). Pepsinogen B is the name of a pepsinogen from pigs.

Also Known As:

Networked: 148 relevant articles (2 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hamajima, Nobuyuki: 6 articles (04/2011 - 01/2006)
2.	Goto, Yasuyuki: 5 articles (04/2011 - 01/2006)
3.	Naito, Mariko: 4 articles (04/2011 - 01/2006)
4.	Shimoyama, Tadashi: 3 articles (09/2012 - 04/2009)
5.	Fukuda, Shinsaku: 3 articles (09/2012 - 04/2009)
6.	Rugge, Massimo: 3 articles (07/2011 - 10/2004)
7.	Sugano, Kentaro: 2 articles (07/2015 - 03/2008)
8.	Malfertheiner, P: 2 articles (04/2015 - 08/2008)
9.	Stolte, Manfred: 2 articles (01/2014 - 01/2011)
10.	Sorokina, N N: 2 articles (02/2013 - 01/2013)

Related Diseases

1.	Gastritis 10/01/2006 - "We sought to study the relationship between serum pepsinogens and different histopathologic features of Helicobacter pylori-related chronic gastritis. " 09/01/2001 - "The aim of this study was to evaluate the diagnostic potential of serum pepsinogens I and II in predicting the topography and severity of gastritis in H. " 09/01/2001 - "It has long been recognised that specific patterns of gastritis are linked with different gastroduodenal diseases and that serum pepsinogens vary with the histological state of the gastric mucosa. " 09/01/2001 - "Variation in serum pepsinogens with severity and topography of Helicobacter pylori-associated chronic gastritis in dyspeptic patients referred for endoscopy." 11/01/1993 - "Serum pepsinogens as markers of response to therapy for Helicobacter pylori gastritis."
2.	Atrophic Gastritis 06/01/2008 - "We evaluated the clinical utility of serum pepsinogens (PG) as a biomarker for screening of atrophic gastritis. " 09/01/2006 - "Relationship between Helicobacter pylori status and serum pepsinogens as serologic markers in atrophic gastritis." 06/01/1996 - "Cases are those who were not diagnosed as having atrophic gastritis in 1991 or 1992 but were diagnosed as having atrophic gastritis in 1995 by the examination of serum pepsinogens. " 01/01/2015 - "Significance of Serum Pepsinogens as a Biomarker for Gastric Cancer and Atrophic Gastritis Screening: A Systematic Review and Meta-Analysis." 01/01/2014 - "Accuracy of pepsinogens for early diagnosis of atrophic gastritis and gastric cancer in Iranian population."
3.	Atrophy 04/01/2011 - "Serum pepsinogens were measured to evaluate gastric atrophy. " 01/01/2009 - "Serum pepsinogens were measured to evaluate gastric atrophy. " 04/01/2008 - "Gastric atrophy was evaluated with serum pepsinogens (PG1<70 ng/ml and PG1/PG2<3). " 04/01/2006 - "Gastric atrophy was evaluated with serum pepsinogens (PGI < 70 ng/dl and PGI/II < 3), and TNF T-1031C and C-857T were genotyped by polymerase chain reaction with confronting two-pair primers (PCR-CTPP). " 01/01/2006 - "Gastric atrophy was evaluated with serum pepsinogens (PGs); PG I, less than 70 ng/dl and PG I/II ratio, less than 3. The genotype frequency of PTPN11 was in Hardy-Weinberg equilibrium: 65.5% for G/G, 30.4% for G/A, and 4.1% for A/A. "
4.	Stomach Neoplasms (Stomach Cancer) 02/01/1999 - "Gastric cancer, cytotoxin-associated gene A-positive Helicobacter pylori, and serum pepsinogens: an international study. " 12/01/1995 - "The aim of this study was to estimate the validity of mass screening for gastric cancer using serum pepsinogens (PG test). " 01/01/1988 - "[Immunomorphologic study of pepsinogens in stomach cancer]." 07/01/2015 - "Randomized controlled trial comparing gastric cancer screening by gastrointestinal X-ray with serology for Helicobacter pylori and pepsinogens followed by gastrointestinal endoscopy." 01/01/2015 - "Serologic screening of gastric cancer (GC) by serum pepsinogens (sPG) levels and Helicobacter pylori (Hp) sero-status, though highly informative, has provided heterogeneous results. "
5.	Duodenal Ulcer (Curling's Ulcer) 04/01/1990 - "The pattern of serum pepsinogens after stopping the drug was different for duodenal ulcer patients and normal subjects. " 05/01/1983 - "Thirty-three duodenal ulcer patients (group A) were examined for gastric acid secretion capacity and serum group I pepsinogens (PG I) under basal conditions. " 02/01/1982 - "Duodenal pepsinogens in experimental duodenal ulcer in rats." 05/01/1983 - "Serum group I pepsinogens in unoperated duodenal ulcer patients and in duodenal ulcer patients after proximal gastric vagotomy." 01/01/1985 - "Immunoperoxidase staining for human group I and group II pepsinogens (PG I, PG II) was performed on stomachs including surgically removed 42 Borrmann IV type gastric carcinomas (B-IV), 6 duodenal ulcers and 6 autopsy cases of traffic accident. "

Related Drugs and Biologics

1.	gastrin 17 (G 17)
2.	Gastrins
3.	Antibodies
4.	Biological Markers (Surrogate Marker)
5.	Pepsinogen A (Pepsinogen)
6.	Pepsinogen C
7.	Omeprazole (Esomeprazole)
8.	beta Carotene (Betacarotene)
9.	Mucins
10.	Monoclonal Antibodies

Related Therapies and Procedures

1.	Proximal Gastric Vagotomy
2.	Gastrectomy
3.	Transplants (Transplant)
4.	Vagotomy
5.	Gastroenterostomy