Usefulness of serum pepsinogens in Helicobacter pylori chronic gastritis: relationship with inflammation, activity, and density of the bacterium.
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| Abstract |
We sought to study the relationship between serum pepsinogens and different histopathologic features of Helicobacter pylori-related chronic gastritis. One hundred forty-nine consecutive dyspeptic patients underwent endoscopy with biopsies; serum pepsinogens I and II were measured by immunoassay. Serum levels of pepsinogens (sPG) were significantly correlated with H. pylori density both of the corpus (sPGI: r = 0.32, P < .001; sPGII: r = 0.56, P < .001) and antrum (sPGI: r = 0.41, P < .001; sPGII: r = 0.43, P < .001) as well as with chronic inflammation (sPGI: r = 0.26, P < .001; sPGII: r = 0.49, P < .001) and activity (sPGI: r = 0.38, P < .001; sPGII: r = 0.50, P < .001) in the antrum. Only sPGII was correlated with chronic inflammation (r = 0.44, P < .001) and activity (r = 0.40, P < .001) in the corpus. SPGI was inversely correlated with atrophy (r = -0.33, P < .001) and intestinal metaplasia (r = -0.37, P < .001) in the corpus. sPGII levels could be considered as markers of gastric inflammation all over in the stomach. sPGI levels are inversely related to atrophic body gastritis.
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| Authors | Francesco Di Mario, Lucas Giovanni Cavallaro, Ali Mahamat Moussa, Pietro Caruana, Roberta Merli, Andrea Maini, Simone Bertolini, Nadia Dal Bó, Massimo Rugge, Giulia Martina Cavestro, Giovanni Aragona, Mario Plebani, Angelo Franzé, Giorgio Nervi |
| Journal | Digestive diseases and sciences (Dig Dis Sci) Vol. 51 Issue 10 Pg. 1791-5 (Oct 2006) ISSN: 0163-2116 [Print] United States |
| PMID | 17203556 (Publication Type: Journal Article) |
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