Mucins

High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.

Also Known As:

Networked: 7065 relevant articles (111 outcomes, 694 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Batra, Surinder K: 56 articles (12/2015 - 01/2002)
2.	Van Seuningen, Isabelle: 34 articles (12/2015 - 12/2003)
3.	Yonezawa, Suguru: 28 articles (07/2015 - 01/2002)
4.	Nakanuma, Yasuni: 25 articles (03/2014 - 05/2002)
5.	Batra, S K: 21 articles (09/2015 - 06/2000)
6.	Jonckheere, Nicolas: 19 articles (12/2015 - 12/2003)
7.	Higashi, Michiyo: 18 articles (07/2015 - 01/2004)
8.	Hansson, Gunnar C: 18 articles (12/2014 - 01/2002)
9.	Klimstra, David S: 18 articles (10/2012 - 01/2002)
10.	Kim, Young S: 18 articles (10/2010 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2014 - "Expected 5 year disease free and overall survival for mucin positive and mucin negative tumors was 73% and 89% (P = 0.1) and 75% and 87% (P = 0.4). " 11/01/1998 - "Intraluminal ultrasonography, EUS and IDUS are very useful in making a differential diagnosis between benign and malignant tumors in mucin-producing pancreatic tumors." 01/01/2008 - "From these results, the development of new biological tools targeting mucins has been increasing and the recent attention given to these complex molecules may bring hope for improved cancer treatments in the future. " 08/01/2009 - "Furthermore, the results indicated that EGFR overexpression and histologic subtyping by predominant tumor cell type in mucin pools may be helpful for predicting clinical outcome in patients with MGC." 07/01/2003 - "As age increased, the characteristics of tumor stage at diagnosis, tumor differentiation, and mucin production improved."
2.	Infection 01/01/2015 - "Mucins secreted by intestinal goblet cells are considered an important component of innate defense in a number of enteric infections, including many parasitic infections, but also likely provide protection against the gut microbiota. " 01/01/2012 - "In this paper we present the latest knowledge about these intriguing interactions of both mucins and their interplay with the pathogen providing protection against infection." 01/01/2015 - "The study was designed to compare males with females for the susceptibility to Eimeria papillata infection as well as the expression of the mucin gene, MUC2. " 01/01/2013 - "The concept of the mucus layer functioning as a dynamic protective barrier is suggested by studies showing changes in mucins in inflammatory conditions of the GI tract, by the altered goblet cell response in germ-free animals, and by the enhanced mucus secretion seen in response to infections. " 01/01/2012 - "In contrast to previous studies, crude saliva and purified mucins from both HIV negative and HIV positive individuals inhibited the infection of HIV-1 in an in vitro assay. "
3.	Carcinoma (Carcinomatosis) 07/01/2002 - "Thus mucin stains are very helpful in deciding the types of carcinoma cervix and should be done in all cases of carcinoma cervix in order to avoid errors in diagnosis and to detect poorly differentiated mixed carcinomas, which may escape detection by H&E staining." 08/01/2015 - "Endocrine mucin-producing sweat gland carcinoma: a study of three cases and CK8, CK18 and CD5/6 immunoexpression." 08/01/2015 - "The objective of the present study was to characterize the morphological features and mucin expression profile of breast carcinomas with SRC differentiation. " 10/01/2014 - "WT1 expression in endocrine mucin-producing sweat gland carcinoma: a study of 13 cases." 09/01/2014 - "Although several studies have shown that the presence of acellular mucin pools in surgical specimens with rectal carcinomas examined after preoperative chemoradiotherapy indicated complete response to therapy, the proper meaning of these pools has yet to be elucidated. "
4.	Adenocarcinoma 12/01/1991 - "However, remnants of the apical mucous secretion from the "ordinary" pyloric cells, the nuclei usually near the free border of the cells, as well as the negative reaction in the "glassy" cytoplasm for neutral and acid mucins, helped to differentiate them from signet-ring adenocarcinoma cells." 01/01/1988 - "We confirm previous observations that intraluminal crystalloids and mucin are helpful in diagnosing prostate adenocarcinoma." 01/01/1986 - "Therefore resulted: the mucin pattern of the normal endocervical epithelium is related to the menstrual cycle; the histochemical evaluation of mucous secretion, presently doesn't seem to be helpful in differentiating endocervical from endometrial adenocarcinomas." 07/01/2015 - "The aim of this study was to further examine the utility of mucin (MUC) expression profiles as prognostic factors in pancreatic ductal adenocarcinoma (PDAC). " 02/01/2013 - "Napsin A expression in primary mucin-producing adenocarcinomas of the lung: an immunohistochemical study."
5.	Colonic Neoplasms (Colon Cancer) 05/01/2014 - "This study examines the relationship between increased mucin production and outcomes in colon cancer. " 11/01/2011 - "To study the regulation of the mucin protein in colon cancer cell line HT-29 by recombinant human interleukin-6(rIL-6) and to further elucidate the development of colon cancer. " 09/01/2000 - "In the present study, we sought to determine the effect of PMA on mucin gene expression and on the biological properties of a human colon cancer cell line, HM3. " 09/01/1997 - "The present study was undertaken to evaluate the influence of hormonal variations of the menstrual cycle on the mucin histochemistry of normal colonic mucosa and to analyse its significance in relation to colon cancers. " 04/01/1984 - "[Study of mucin histochemistry of the mucous cell of the colon--with special reference to its relationship to colonic cancer]."

Related Drugs and Biologics

1.	Mucins
2.	Antigens
3.	Immunoglobulins (Immunoglobulin)
4.	Glycoproteins (Glycoprotein)
5.	Antibodies
6.	Monoclonal Antibodies
7.	Messenger RNA (mRNA)
8.	Sialomucins
9.	Biological Markers (Surrogate Marker)
10.	sulfomucin

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Catheters
4.	Pancreatectomy
5.	Radiotherapy