Abstract | BACKGROUND: Patients with impaired renal function have been known to have elevated concentrations of serum pepsinogens, which are raised by Helicobacter pylori infection of the stomach. The present study was performed to examine the effect of H. pylori infection on serum pepsinogen concentrations in dialysis patients. METHODS: Forty nine patients on dialysis and 48 subjects with no known kidney disease were examined for upper gastroduodenal endoscopy, H. pylori infection and serum concentrations of pepsinogen I and II. The status of H. pylori infection was evaluated from results of a urease test, histology and culture of biopsy specimens of the gastric mucosa. Serum pepsinogen levels were measured by radioimmunoassay. RESULTS: CONCLUSIONS: We conclude that H. pylori status should be taken into account when serum pepsinogen concentrations are evaluated in dialysis patients.
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Authors | H Tamura, H Tokushima, M Murakawa, O Matsumura, S Itoyama, T Mitarai, K Isoda |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 14
Issue 1
Pg. 113-7
(Jan 1999)
ISSN: 0931-0509 [Print] England |
PMID | 10052488
(Publication Type: Journal Article)
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Chemical References |
- Pepsinogen C
- Pepsinogen A
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Topics |
- Female
- Gastritis
(etiology)
- Helicobacter Infections
(blood, complications, enzymology)
- Helicobacter pylori
- Humans
- Kidney Failure, Chronic
(blood, enzymology, therapy)
- Male
- Middle Aged
- Pepsinogen A
(blood)
- Pepsinogen C
(blood)
- Peritoneal Dialysis, Continuous Ambulatory
- Radioimmunoassay
- Reference Values
- Renal Dialysis
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