Relationship between Helicobacter pylori status and serum pepsinogens as serologic markers in atrophic gastritis.

Abstract

BACKGROUND/AIMS:

Serum pepsinogen levels are considered as a non-endoscopic blood test in the diagnosis of atrophic gastritis. The objective of the present study was to investigate whether there is any difference between pepsinogen levels in Helicobacter pylori-positive and -negative patients with atrophic gastritis, and to analyze the relationship between histopathology and pepsinogen levels after treatment in H. pylori-positive patients with atrophic gastritis.

METHODS:

The study enrolled a total of 30 cases with atrophic gastritis (18 H. pylori-positive and 12 H. pylori-negative). The H. pylori-positive cases received a one-week eradication treatment. Initially for all and after the treatment for H. pylori-positive cases, serum pepsinogen I and II levels, anti-H. pylori IgG titration and histopathologic analysis were carried out.

RESULTS:

In the H. pylori-positive patients with atrophic gastritis, the levels of pepsinogen I and pepsinogen I/II ratio were lower while the levels of pepsinogen II were higher compared to the H. pylori-negative patients (p<0.05 for all). The post-treatment serum pepsinogen I levels and pepsinogen I/II ratios did not change in the H. pylori-positive group, while the levels of pepsinogen II, H. pylori antibody titration and gastric atrophy degree remarkably decreased (p<0.05 for all).

CONCLUSIONS:

In atrophic gastritis, the levels of serum pepsinogen and pepsinogen I/II ratio show a difference in H. pylori-negative versus -positive cases. Additionally, the usage of pepsinogen II as a serum marker in predicting the eradication of H. pylori with atrophic gastritis could be more reliable than pepsinogen I or the I/II ratio.

• Authors: Cengiz Bölükbaş, Füsun F Bölükbaş, Oya Ovünç, Güray Kiliç, Remzi Dalay, Hatice Güven, Fikriye Uras, Turay K Yardimci, Mehmet H Sökmen, Ahmet F Agan, Nezih Pişkinpaşa
• Journal: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology (Turk J Gastroenterol) Vol. 17 Issue 3 Pg. 172-6 (Sep 2006) ISSN: 1300-4948 [Print] Turkey
• PMID: 16941249 (Publication Type: Journal Article)

Chemical References

• Antibodies, Bacterial
• Immunoglobulin G
• Pepsinogen C
• Pepsinogen A

Topics

• Adult
• Antibodies, Bacterial (blood)
• Case-Control Studies
• Female
• Follow-Up Studies
• Gastric Mucosa (microbiology, pathology)
• Gastritis, Atrophic (diagnosis, enzymology, microbiology)
• Helicobacter Infections (diagnosis, microbiology)
• Helicobacter pylori (immunology, isolation & purification)
• Humans
• Immunoglobulin G (blood)
• Male
• Middle Aged
• Pepsinogen A (blood)
• Pepsinogen C (blood)
• Predictive Value of Tests
• Pyloric Antrum (microbiology, pathology)
• Serologic Tests