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Nervous System Malformations (Nervous System Congenital Malformations)

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Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.

Also Known As:

Nervous System Congenital Malformations; Abnormalities, Congenital, Nervous System; Abnormalities, Nervous System; Anomalies, Nervous System; Congenital Abnormalities, Nervous System; Congenital Anomalies, Nervous System; Congenital Malformations, Nervous System; Cranioschisis; Malformations, Nervous System, Congenital; Nervous System Anomalies; Nervous System Congenital Abnormalities; Nervous System Malformations, Congenital; Abnormality, Nervous System; Anomaly, Nervous System; Cranioschises; Malformation, Nervous System; Malformations, Nervous System; Nervous System Abnormality; Nervous System Anomaly; Nervous System Malformation; Nervous System Abnormalities

Networked: 24 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neural Tube Defects (Exencephaly)
2.	Seizures (Seizure)
3.	Chloracne
4.	Neurodegenerative Diseases (Neurodegenerative Disease)
5.	Hyperpigmentation

Experts

1.	MacPhail, Robert: 1 article (04/2012)
2.	Hunter, Deborah: 1 article (04/2012)
3.	Jensen, Karl: 1 article (04/2012)
4.	Cowden, John: 1 article (04/2012)
5.	Padilla, Stephanie: 1 article (04/2012)
6.	Padnos, Beth: 1 article (04/2012)
7.	Qu, Xun: 1 article (12/2010)
8.	Zhan, Xinfeng: 1 article (12/2010)
9.	Liu, Cun: 1 article (12/2010)
10.	Ma, Zhe: 1 article (12/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nervous System Malformations:

1.	Anti-Bacterial Agents (Antibiotics)IBA 07/01/1989 - "Usually, there will be significant improvement following the use of antibiotics, but there are some patients who will continue to have persistent, probably irreversible, nervous system abnormalities. "
2.	Warfarin (Coumadin)FDA LinkGeneric 01/01/1985 - "In studies with the cranioschisis gene administration of warfarin and thyroxine resulted in frequencies of exencephaly significantly below that expected of a recessive trait, perhaps indicating selective elimination of abnormal conceptuses. "
3.	Thyroxine (Levothyroxine)FDA LinkGeneric 01/01/1985 - "In studies with the cranioschisis gene administration of warfarin and thyroxine resulted in frequencies of exencephaly significantly below that expected of a recessive trait, perhaps indicating selective elimination of abnormal conceptuses. "
4.	Ethanol (Ethyl Alcohol)IBA 04/01/1983 - "Cranioschisis was maximal on d 7, 11, and 15, and microcephalic offspring were most frequently born to dams given ethanol on d 7 or 14. " 11/01/1986 - "Exposure of the mammalian fetus to ethanol causes a variety of nervous system abnormalities, but the evidence relating to seizure susceptibility is contradictory. " 04/01/1983 - "Malformations such as hydronephrosis, pelvic kidney, microcephalus, cranioschisis, and microphthalmia occurred in 72-100% of the ethanol treated offspring, as compared to 12% of controls. " 04/01/2012 - "Embryos were exposed to nominal concentrations of either valproate or ethanol then examined for lethality, malformation, nervous system structure and locomotor activity. "
5.	Chromogranin AIBA 05/01/1993 - "Several lines of evidence link chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, with the cholinergic nervous system, abnormalities of which may play a central role in memory deficits in Alzheimer dementia. "
6.	Vitamin B 6IBA 08/01/1989 - "We examined the sequence of nervous system abnormalities that resulted when rats were given excess amounts of vitamin B6 (pyridoxine). "
7.	Nerve Growth Factor (NGF)IBA 08/15/1999 - "In addition, these data suggest that nervous system abnormalities observed in diabetic embryopathy may also derive by insufficient neurotrophic factor biosynthesis involving sequentially NGF in the embryo and BDNF and IGF-I in the early postnatal days. "
8.	Brain-Derived Neurotrophic Factor (BDNF)IBA 08/15/1999 - "In addition, these data suggest that nervous system abnormalities observed in diabetic embryopathy may also derive by insufficient neurotrophic factor biosynthesis involving sequentially NGF in the embryo and BDNF and IGF-I in the early postnatal days. "
9.	AnkyrinsIBA 04/01/1999 - "Ankyrin-B and L1 thus are candidates to collaborate in the same structural pathway and defects in this pathway can lead to nervous system malformations and mental retardation. "
10.	VitaminsIBA 01/01/1987 - "Possible mechanisms for this nervous system abnormality, not previously reported in vitamin B-6 deficiency, are discussed." 01/01/1987 - "Vitamin B-6 deficient rats exhibit changes in behavior, sensory function, and other nervous system abnormalities such as convulsive seizures and motor disturbances. "

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 06/01/1980 - "Early dialysis and/or transplantation should be considered in such children in an attempt to modify the serious nervous system abnormalities."
2.	Lasers (Laser) 12/01/2010 - "Different protein profile in amniotic fluid with nervous system malformations by surface-enhanced laser desorption-ionization/time-of-flight mass spectrometry (SELDI-TOF-MS) technology." 12/01/2010 - "Surface-enhanced laser desorption-ionization/time-of-flight mass spectrometry was used to characterize AF peptides in AF between nervous system malformations fetuses and normal fetuses. "