Vitamin B 6

VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.

Also Known As:

Networked: 1243 relevant articles (82 outcomes, 204 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Selhub, Jacob: 19 articles (12/2013 - 07/2002)
2.	Kato, Norihisa: 10 articles (05/2014 - 05/2003)
3.	Giovannucci, Edward: 10 articles (04/2013 - 05/2005)
4.	Ueland, Per Magne: 9 articles (01/2015 - 09/2004)
5.	Hankey, Graeme J: 8 articles (08/2013 - 01/2008)
6.	Lerner, Vladimir: 8 articles (07/2008 - 01/2002)
7.	Miodownik, Chanoch: 8 articles (07/2008 - 01/2002)
8.	Midttun, Øivind: 6 articles (06/2015 - 06/2010)
9.	Yanaka, Noriyuki: 6 articles (05/2014 - 04/2011)
10.	Eikelboom, John W: 6 articles (08/2013 - 06/2008)

Related Diseases

1.	Nausea 12/01/2009 - "compared with baseline, the decrease in the visual analogue scores of post-therapy nausea in the ginger group was significantly greater than that for the vitamin B6 group (p = 0.024). " 12/01/2009 - "In the ginger group, 29/35 women reported an improvement in nausea symptoms, compared with 23/34 women in the vitamin B6 group (p = 0.52). " 01/01/2013 - "In a clinical trial in health centers of Qazvin University of Medical Sciences from November 2010 to February 2011 on pregnant mothers, the effects of vitamin B6 (40 mg twice daily) and ginger (250 mg four times daily) were evaluated in treatment of pregnancy nausea. " 01/01/2013 - "Comparing the effectiveness of vitamin B6 (40 mg twice daily) and ginger (250 mg four times daily) in treatment of pregnancy nausea. " 09/01/2003 - "The ginger and vitamin B6 significantly reduced the nausea scores from 5.0 (SD, 1.99) to 3.6 (SD, 2.48) and 5.3 (SD, 2.08) to 3.3 (SD, 2.07) respectively, with p < 0.001. "
2.	Vomiting 01/01/2013 - "Vomiting was more reduced in vitamin B6 group; however, this reduction was not statistically significant. " 09/01/2003 - "The ginger and vitamin B6 also significantly reduced the number of vomiting episodes from 1.9 (2.06) to 1.2 (1.75) and 1.7 (1.81) to 1.2 (1.50) respectively, with p < 0.01. " 07/01/1991 - "At the completion of 3 days of therapy, only eight of 31 patients in the vitamin B6 group had any vomiting, compared with 15 of 28 patients in the placebo group (P less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)" 02/01/1966 - "[Post anesthetic vomiting and vitamin B 6 prophylaxis]." 12/02/1961 - "[Research on the effect of vitamin B6 on postanesthesia vomiting]."
3.	Neoplasms (Cancer) 07/01/1996 - "A comparison of the control, remission and other ailments groups with the cancer patient groups shows them to be significantly different (P < 0.00001) and strongly supports the use of the novel vitamin B6 conjugate metabolite for detection of human cancers." 07/01/1996 - "The results show that the level of the vitamin B6 metabolite in the blood of cancer patients is up to 4x or higher than levels seen in the blood of normal volunteers, patients in remission or patients with other diseases. " 04/01/2012 - "This study provides an insight into the genomic activities of dietary vitamin B6 that may be protective against colon tumor development." 08/15/1996 - "The results show that the level of the vitamin B6 conjugate in the circulation of control subjects, cancer patients in remission, and patients with other diseases was only minimal. " 06/15/2015 - "Markers of vitamin B6 status and metabolism as predictors of incident cancer: the Hordaland Health Study."
4.	Vitamin B 6 Deficiency (Pyridoxine Deficiency) 01/01/1991 - "The present study indicates that vitamin B6 deficiency is prevalent in CDC stage III HIV-1-infected subjects, despite adequate dietary vitamin B6 intake. " 11/01/1977 - "Two metabolic trials using early-weaned piglets were performed to find out whether highly vitamin B6 deficient prest,rter- or starter feeds (0.4 mg vitamin B6/Kg) would affect the excretion and retention of Ca, P, Mg, K and Na as compared with pair-fed control animals given 6.5 mg B6/Kg. The depleted animals showing typical vitamin B6 deficiency symptoms in the course of the trials, were found to excrete in the feces somewhat smaller amounts of minerals during both metabolic periods. " 01/01/2015 - "Over the past years, the essential role of vitamin B6 in brain development and functioning has been recognized and genetic metabolic disorders resulting in functional vitamin B6 deficiency have been identified. " 01/01/2013 - "The main potentially treatable causes comprise vitamin B6 (pyridoxine deficiency), biotine, and GLUT1 deficiency (GLUT1DS) syndromes. " 09/01/2011 - "The aims of this review were (i) to determine the current level of vitamin B(6) deficiency in the haemodialysis population; (ii) to determine the effect of current haemodialysis prescriptions on vitamin B(6) levels; and (iii) to consider the impact of recent medical advances in haemodialysis on vitamin B(6) levels. "
5.	Movement Disorders (Movement Disorder) 11/01/2004 - "In earlier studies, vitamin B6 was found to be effective in the treatment of neuroleptic-induced movement disorders. " 09/01/2001 - "Vitamin B(6) appears to be effective in reducing symptoms of tardive dyskinesia." 07/01/2000 - "There are several reports regarding the efficacy of vitamin B6 in the treatment of tardive dyskinesia (TD). " 07/01/1999 - "Vitamin B6 in treatment of tardive dyskinesia: a preliminary case series study." 07/01/2008 - "Some clinical experiments showed that vitamin B6 may ameliorate different drug-induced movement disorders, including tardive dyskinesia (TD). "

Related Drugs and Biologics

1.	Pyridoxine (Pyridoxin)
2.	Folic Acid (Vitamin M)
3.	Vitamin B 12 (Cyanocobalamin)
4.	Magnesium
5.	Homocysteine
6.	Vitamins
7.	Ascorbic Acid (Vitamin C)
8.	Zinc
9.	Adrenocorticotropic Hormone (ACTH)
10.	Valproic Acid (Valproate, Semisodium)

Related Therapies and Procedures

1.	Injections
2.	Acupressure (Shiatsu)
3.	Transplantation (Transplant Recipients)
4.	Oral Administration
5.	Drug Therapy (Chemotherapy)