Gastrins

A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.

Also Known As:

Networked: 3862 relevant articles (110 outcomes, 469 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Konturek, S J: 35 articles (04/2011 - 01/2000)
2.	Konturek, P C: 30 articles (12/2013 - 01/2000)
3.	Wang, Timothy C: 30 articles (01/2013 - 01/2002)
4.	Baldwin, Graham S: 26 articles (12/2015 - 04/2003)
5.	Varro, Andrea: 25 articles (07/2015 - 07/2002)
6.	Shulkes, Arthur: 24 articles (12/2015 - 01/2004)
7.	Brzozowski, T: 18 articles (12/2013 - 01/2000)
8.	Konturek, Peter C: 18 articles (01/2011 - 04/2002)
9.	Rehfeld, Jens F: 17 articles (10/2015 - 09/2002)
10.	Hahn, E G: 17 articles (09/2005 - 01/2000)

Related Diseases

1.	Duodenal Ulcer (Curling's Ulcer) 01/01/1993 - "pylori was eradicated in all patients who have received antibacterial therapy in 4 weeks, and serum gastrin concentrations were significantly decreased after eradication of the organism both in gastric and in duodenal ulcer diseases. " 10/01/1977 - "Gastric acid and gastrin responses to AAM were found to be significantly greater in duodenal ulcer patients than in normal subjects. " 07/01/1977 - "The duodenal ulcer patients showed an augmented and significantly greater release of GIP as well as of gastrin compared to normal subjects. " 02/01/1986 - "Serum gastrin has been reported to increase after therapy with some agents effective in the treatment of duodenal ulcer (DU). " 01/01/1985 - "[Dynamics of the basal gastrin concentration of duodenal ulcer patients during the development of remission of the disease]."
2.	Neoplasms (Cancer) 03/01/1986 - "Mice bearing gastrin-stimulated tumors died at a significantly greater rate than did mice with untreated tumors (80% of control mice and none of the treated mice were alive at day 55). " 09/01/2015 - "This increased tumor uptake, visualized also by SPECT/CT imaging, is expected to eventually translate into higher diagnostic sensitivity and improved therapeutic efficacy of radiolabeled gastrin analogs in CCK2R-expressing cancer patients." 09/01/2015 - "Radiolabeled gastrin/CCK analogs in tumor diagnosis: towards higher stability and improved tumor targeting." 01/01/2004 - "It is expected that targeting precursor gastrins (progastrins and gly-gastrins), exclusively rather than amidated gastrins, may be more effective for treating GI cancers. " 04/01/1986 - "Three patients have had no detectable tumor on follow-up, and two of these patients are clinically and biochemically "cured" with normal fasting gastrin levels and negative provocative gastrin tests at 14 and 32 months. "
3.	Infection 12/01/2014 - "The level of gastrin was 134.4±145.6 pg/mL in 224 patients with H. pylori infection and the level was significantly higher when compared with those in uninfected subjects and eradicated patients (P<0.01). " 05/01/1998 - "pylori-cured patients meal-induced gastrin and fasting PGI levels were significantly reduced after 6 months as compared with pretreatment values (peak serum gastrin, 76.0 +/- 23.4 versus 111.9+/-37.4 pg/ml; PGI, 57.1+/-23.4 versus 72.9+/-29.1 ng/ml), whereas they remained virtually unchanged in the 15 patients with persistent infection. " 03/01/1996 - "In our group of 15 patients with HP infection in coexistence with chronic active antrumgastritis we have found a significant decrease in the basal level of serum gastrin (p = 0,01) after successful therapy. " 05/01/2000 - "Cure of infection was associated with improvement in both basal (basal acid output mean 0.23 +/- 0.14 mmol/h vs. 1.75 +/- 0.7 mmol/h, P < 0.005) and stimulated acid secretion (peak acid output mean 3.0 +/- 1.06 mmol/h vs. 16.6 +/- 4.1 mmol/h, P=0.0017) as well as with reduction in hypergastrinemia (mean gastrin levels 444.1 +/- 110.7 pg/mL vs. 85.3. " 01/01/2011 - "Single studies are devoted to changes in serum gastrin levels in diseases, including infection pathology, of the body's other organs and systems other than the gastrointestinal tract. "
4.	Gastrinoma 12/01/1989 - "These four patients are well and have returned to work, and their serum gastrin levels are below 35 pg/mL. Thus we believe SASI and IOS tests are helpful for planning curative resection of gastrinomas." 08/01/1995 - "The introduction of sensitive radioimmunoassays for gastrin has led to the earlier and more accurate diagnosis of gastrinomas and, as methods for tumour localization both pre- and intraoperatively have improved, the emphasis of surgery has changed from control of gastric acid secretion to tumour removal. " 03/01/1992 - "Among these are a 74-year-old man who was cured after endoscopic removal of a submucosal duodenal gastrinoma, suggesting the usefulness of an operative approach using intraoperative endoscopic transillumination; a 33-year-old man in whom the manifestations of ZES brought him into conflict with the law; and a 10-year-old domestic cat who was cured surgically, the gastrinoma providing material for the first determination of the sequence of cat gastrins." 03/01/2006 - "This study confirms that a gastrinoma cannot be diagnosed on the basis of a fasting plasma gastrin assay while patients remain on PPI/H2 therapy." 04/01/1999 - "The aim of the current study was to assess this finding and compare the results with those from serum gastrin determinations (FSG) in a large cohort of patients with gastrinomas. "
5.	Ulcer 09/01/1986 - "Ulcer patients developed higher serum gastrin concentrations during G-17 infusion due to nearly twofold slower clearance of gastrin (8.8 vs. 15.7 ml/kg X min; P less than 0.01). " 10/01/1976 - "Gastrin determination therefore is not helpful in the choice of the correct operative procedure for the ulcer disease. " 03/01/1976 - "Results of this study suggest that the increased concentration of circulating gastrin in normal dogs subjected to severe stress may play a role in the development of a stress ulcer." 08/01/1964 - "The clinical studies are still tentative in view of the several variables present, but it seems likely that they will in due course clarify the role of gastrin in the ulcer problem." 01/01/2009 - "The presence of hypertrophic and heterotopic gastric mucosa is proposed to result from increased gastrin levels and may contribute to the increased incidence of postbulbar ulcers in these patients."

Related Drugs and Biologics

1.	Pepsinogen A (Pepsinogen)
2.	Antral
3.	Somatostatin (Somatotropin Release-Inhibiting Factor)
4.	Secretin
5.	Bombesin
6.	Omeprazole (Esomeprazole)
7.	big gastrin
8.	Messenger RNA (mRNA)
9.	Adrenocorticotropic Hormone (ACTH)
10.	Immunoglobulin G (IgG)

Related Therapies and Procedures

1.	Vagotomy
2.	Aftercare (After-Treatment)
3.	Gastrectomy
4.	Pancreaticoduodenectomy
5.	Drug Therapy (Chemotherapy)