Alamethicin

A cyclic nonadecapeptide antibiotic that can act as an ionophore and is produced by strains of Trichoderma viride. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Networked: 17 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Brimble, Margaret A: 1 article (01/2021)
2.	Hanna, Cameron C: 1 article (01/2021)
3.	Harris, Paul W R: 1 article (01/2021)
4.	Hermant, Yann O: 1 article (01/2021)
5.	Burdette, Joanna E: 1 article (01/2017)
6.	Graf, Tyler N: 1 article (01/2017)
7.	Oberlies, Nicholas H: 1 article (01/2017)
8.	Pearce, Cedric J: 1 article (01/2017)
9.	Raja, Huzefa A: 1 article (01/2017)
10.	Rivera-Chávez, José: 1 article (01/2017)

Related Diseases

1.	Infections 01/01/2013 - "graminicola infection or treatment with alamethicin. " 05/01/2002 - "Furthermore, 8 days of treatment of HeLa cell cultures experimentally contaminated with either mycoplasma species with 70 microM enrofloxacin cured the cultures of infection, whereas treatment with alamethicin and gramicidin S alone was not reliable because the concentrations and treatment times required were toxic to the cells. "
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2007 - "Epigallocatechin gallate also inhibited beta-glucuronidase activity in native Hepa 1c1c7 mouse hepatoma cells, while failed to affect the enzyme in alamethicin-permeabilized cells, where the endoplasmic membrane barrier was eliminated. "
3.	Neuroblastoma 03/06/2006 - "Studies were conducted with alamethicin-permeabilized SH-SY5Y human neuroblastoma cells. " 12/01/1989 - "Utilizing whole cells treated with alamethicin, total (Na+ + K+)-ATPase activity was determined in clonal pheochromocytoma cells (PC12), neuroblastoma x glioma hybrid cells (NG108-15), and myocytes isolated from adult and neonatal rat hearts. " 01/01/2009 - "Differential short-term cellular responses were observed between botulinum neurotoxin A and ricin toxin with neuroblastoma cells, alamethicin and anthrax protective antigen with RAW macrophages, and cholera toxin, muscarine, 2,4-dinitro-phenol, and NaF with CHO cells. "
4.	Rupture 08/04/2005 - "We find that although alamethicin is too small to span the bilayer, the peptide interacts with, and ruptures, thick polymer membranes." 06/01/2010 - "Importantly, whereas low peptide concentrations leave pure POPC liposomes intact and seemingly unperturbed, POPC liposomes supplemented with 40 mol.% cholesterol change their shape, rupture and fuse in response to the addition of both melittin and alamethicin. "
5.	Pheochromocytoma 12/01/1989 - "Utilizing whole cells treated with alamethicin, total (Na+ + K+)-ATPase activity was determined in clonal pheochromocytoma cells (PC12), neuroblastoma x glioma hybrid cells (NG108-15), and myocytes isolated from adult and neonatal rat hearts. " 06/01/2007 - "To this end, membrane permeabilization of the neuron-like rat pheochromocytoma cell (PC12) by the channel-forming ZER was studied with the whole-cell patch-clamp technique, and compared with the permeabilizations of the well-known voltage-gated peptaibol alamethicin F50/5 (ALA) and the cation channel-forming peptide-antibiotic gramicidin D (GRAM). "

Related Drugs and Biologics

1.	Gramicidin (Gramicidin A)
2.	Enzymes
3.	Glucuronidase
4.	Enrofloxacin
5.	epigallocatechin gallate (epigallocatechin-3-gallate)
6.	Peptides (Polypeptides)
7.	Peptaibols
8.	Lipids
9.	Anti-Bacterial Agents (Antibiotics)
10.	Adenosine Triphosphatases (ATPase)