Cyclic Peptides

Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).

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Networked: 55 relevant articles (3 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schmitt, Manfred: 3 articles (01/2003 - 09/2002)
2.	Magdolen, Viktor: 3 articles (01/2003 - 09/2002)
3.	Kessler, Horst: 3 articles (01/2003 - 09/2002)
4.	Wang, Conan K: 2 articles (09/2014 - 01/2014)
5.	Craik, David J: 2 articles (09/2014 - 01/2014)
6.	Gilon, Chaim: 2 articles (01/2012 - 01/2005)
7.	Bondu-Hawkins, Virginie: 2 articles (09/2009 - 06/2008)
8.	Hall, Pamela R: 2 articles (09/2009 - 06/2008)
9.	Larson, Richard S: 2 articles (09/2009 - 06/2008)
10.	Ye, Chunyan: 2 articles (09/2009 - 06/2008)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2002 - "This paper reported an ongoing study of cyclic peptides as carriers of potential anti-tumor agents. " 08/02/2001 - "This study demonstrates a possibility of mimicking the well-documented antibody effects and its applications in tumor therapy by much smaller antibody-based cyclic peptides with potentially significant therapeutic advantages. " 08/01/2012 - "Although cyclization does not necessarily improve the cancer-targeting properties of linear analogues, cyclic peptides may obtain properties that allow them to be used for additional applications. " 01/01/2012 - "There are many cyclic peptides with diverse biological activities, such as antibacterial activity, immunosuppressive activity, and anti-tumor activity, and so on. " 07/31/2009 - "Using biophysical methods and fluorescence microscopy, we show that pHLIP can successfully deliver polar and membrane-impermeable cyclic peptides linked to its C terminus through the membranes of lipid vesicles and cancer cells. "
2.	Inflammation 07/21/2005 - "More importantly, one of the cyclic peptides showed a protective effect against inflammation and articular destruction in DBA/1 mouse collagen-induced arthritis, a model of RA. " 10/10/1997 - "Recently peptides containing a consensus LDV sequence based on the connecting segment-1 (CS-1) of fibronectin and cyclic peptides containing an RCD motif have shown promise in modulating leukocyte migration and inflammation presumably by blocking the interaction of alpha 4 beta 1 with VCAM-1. "
3.	Melanoma (Melanoma, Malignant) 07/01/2001 - "In the present study we investigated whether AVPs carrying cyclic peptides with an RGD integrin binding motif (RGD-AVPs) are suitable for the specific and efficient transduction of human melanoma cells. " 04/01/2010 - "Biodistribution and imaging studies in the B16 mouse melanoma modeled showed rapid tumor uptake of the radiolabeled peptides, with the cyclic peptides demonstrating prolonged tumor retention. "
4.	Multiple Sclerosis 01/17/2014 - "Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis." 03/10/2005 - "The mutant cyclic peptides, the cyclo(91-99)[Ala(96)]MBP(87)(-)(99) and the cyclo(87-99)[Arg(91)Ala(96)]MBP(87)(-)(99), reported previously for suppressing, to a varying degree, autoimmune encephalomyelitis in a rat animal model, were found in this study to possess the following immunomodulatory properties: (i) they suppressed the proliferation of a CD4 T-cell line raised from a multiple sclerosis patient, (ii) they scored the best in vitro TH2/TH1 cytokine ratio in peripheral blood mononuclear cell cultures derived from 13 multiple sclerosis patients, inducing IL-10 selectively, and (iii) they bound to HLA-DR4, first to be reported for cyclic MBP peptides. "
5.	Amyloid Plaque 03/13/2008 - "Here we report on the synthesis, antibody binding, and QSAR studies of a series of linear and cyclic peptides containing a beta-amyloid plaque-specific epitope (Abeta(4-10); FRHDSGY). "

Related Drugs and Biologics

1.	Peptides
2.	Histones (Histone)
3.	Fibronectins (Fibronectin)
4.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
5.	Rhenium
6.	Lysine (L-Lysine)
7.	Ligands
8.	Benzamides
9.	Paclitaxel (Taxol)
10.	Interleukin-10 (Interleukin 10)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Traditional Medicine (Folk Remedies)