Cyclic Peptides

Peptides whose amino acid residues are linked together forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS; some are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).

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Networked: 530 relevant articles (30 outcomes, 61 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tan, Ninghua: 14 articles (06/2022 - 09/2009)
2.	Wang, Zhe: 10 articles (06/2022 - 08/2015)
3.	Craik, David J: 8 articles (01/2021 - 01/2014)
4.	Lam, Kit S: 8 articles (10/2019 - 10/2005)
5.	Parang, Keykavous: 6 articles (01/2020 - 01/2013)
6.	Wilce, Jacqueline A: 6 articles (10/2019 - 09/2007)
7.	Chen, Huachao: 5 articles (01/2021 - 01/2017)
8.	Gruber, Christian W: 5 articles (01/2021 - 01/2014)
9.	Holthoff, Hans-Peter: 5 articles (01/2021 - 11/2012)
10.	Ungerer, Martin: 5 articles (01/2021 - 11/2012)

Related Diseases

1.	Neoplasms (Cancer) 04/12/2021 - "A large number of natural cyclopeptides have been reported to be highly effective against different cancer cells, some of which are renowned for their clinical uses. " 04/30/2017 - "The best cyclopeptide-free analogues preserved efficacy against Plasmodium falciparum and cancer cell lines. " 01/01/2022 - "The cyclic peptides demonstrated up to a 34-fold improvement in the PD-1/PD-L1 blocking activity and significant in vivo anti-tumor activity. " 01/01/2019 - "Here we improved the binding affinity to CK2α and cell-based anti-cancer activity of a CK2β-derived cyclic peptide (Pc) by combining structure-based computational design with experimental evaluation. " 01/01/2023 - "The study indicated dimerization and cyclic peptide structures as promising strategies for prolonging tumor residence time, sparing healthy tissues. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2017 - "The study highlights the discovery of a novel proteolytically stable cyclic peptide that can be used for targeted drug delivery or for enumerating circulating breast tumor cells." 01/08/2009 - "Based on the established structure-activity relationship (SAR) study, two highly focused cyclic peptide libraries were further designed, synthesized, and screened against MDA-MB-231 breast cancer cells under stringent conditions. " 10/17/2019 - "Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity." 01/01/2019 - "A novel formulation significantly increases the cytotoxicity of flaxseed orbitides (linusorbs) LOB3 and LOB2 towards human breast cancer MDA-MB-231 cells." 01/01/2018 - "Efficacy and tolerability of AFPep, a cyclic peptide with anti-breast cancer properties."
3.	Glioblastoma (Glioblastoma Multiforme) 01/01/2009 - "One-bead one-compound combinatorial cyclic peptide libraries were screened with live human glioblastoma U-87MG cells. " 01/01/2022 - "The cyclic peptide (referred to as BGF1) effectively inhibited the FGF2-induced proliferation of HUVECs, 4T1 mammary carcinoma, U87 glioblastoma, and SKOV3 ovarian carcinoma cells. " 05/01/2023 - "The αvβ3 integrin-binding peptide cyclic RGD was utilized to modify codelivery system to achieve glioblastoma targeting strategy. " 12/01/2009 - "Cilengitide is a cyclic peptide antagonist of integrins alphavbeta3 and alphavbeta5 that is currently being evaluated as a novel therapeutic agent for recurrent and newly diagnosed glioblastoma. " 04/03/2023 - "Here the SA installation at the C terminus of an integrin-binding cyclopeptide, leading to enhanced ligand affinity for the receptor as well as stronger biological activity in cultured glioblastoma cells is reported."
4.	Inflammation (Inflammations) 06/10/2020 - "Flaxseed orbitides, linusorbs, inhibit LPS-induced THP-1 macrophage inflammation." 11/25/2019 - "Collectively, the engineered head-to-tail cyclic peptide OIR3 was considerable potential candidate for use as a clinical therapeutic for the treatment of bacterial infections and skin inflammation." 01/01/2017 - "An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease." 07/21/2005 - "More importantly, one of the cyclic peptides showed a protective effect against inflammation and articular destruction in DBA/1 mouse collagen-induced arthritis, a model of RA. " 06/28/2017 - "Importantly, when the lead cyclic peptide c[wLwReQeR] was administered to mice (ip), it also promoted the formation of small, lipid-poor HDLs in vivo, displayed good plasma half-life (∼6 h), did not appear to have adverse side effects, and exerted potent anti-inflammatory effects in an acute in vivo inflammation assay. "
5.	Rheumatoid Arthritis 09/25/2017 - "Efficacy of Bioactive Cyclic Peptides in Rheumatoid Arthritis: Translation from In Vitro to In Vivo Models." 03/01/2017 - "Anti-Citrullinated Cyclic Peptide Antibody and Functional Disability Are Associated With Poor Sleep Quality in Rheumatoid Arthritis." 01/01/2020 - "Anti-citrullinated cyclic peptide antibodies (ACPA) were initially considered very specific for the diagnosis of rheumatoid arthritis (RA), and can predict the prognosis of the disease. " 12/22/2014 - "This paper extends these findings, putting those amino acids into a short cyclic peptide scaffold, and determining the optimal configuration required to overcome the problems of conformational instability, and give rise to molecules which have potential as therapeutic agents in human disease, such as rheumatoid arthritis. " 01/01/2012 - "Developing potent backbone cyclic peptides bearing the shared epitope sequence as rheumatoid arthritis drug-leads."

Related Drugs and Biologics

1.	Integrins
2.	Peptides (Polypeptides)
3.	Proteins (Proteins, Gene)
4.	Ligands
5.	Disulfides
6.	Enzymes
7.	RA V
8.	Amino Acids
9.	Prodrugs
10.	arginyl-glycyl-aspartic acid

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Subcutaneous Injections