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Glucuronidase

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Also Known As:

Endo-beta-D-Glucuronidase; Endoglucuronidase; Exo-beta-D-Glucuronidase; beta-Glucuronidase; Endo beta D Glucuronidase; Exo beta D Glucuronidase; beta Glucuronidase; beta-D-Glucuronoside glucuronosohydrolase

Networked: 1534 relevant articles (43 outcomes, 152 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Glycoside Hydrolases: 275
      - Glucuronidase: 1534
        heparanase: 740
        klotho protein: 35
        mucopolysaccharidase: 20
        glusulase: 1
        alpha-(4-O-methyl)-D-glucuronidase
        glycyrrhetic acid mono-glucuronide beta-glucuronidase
        glycyrrhizin beta-D-glucuronidase
        N-acetyl-beta-glucuronidase

Experts

1.	Sly, William S: 16 articles (01/2016 - 11/2002)
2.	Haskins, Mark E: 16 articles (11/2015 - 02/2002)
3.	Vlodavsky, Israel: 14 articles (01/2012 - 07/2002)
4.	Roffler, Steve R: 13 articles (11/2015 - 11/2002)
5.	Vogler, Carole: 13 articles (10/2012 - 11/2002)
6.	Ponder, Katherine P: 11 articles (02/2015 - 11/2008)
7.	Grubb, Jeffrey H: 11 articles (10/2012 - 11/2002)
8.	Sands, Mark S: 10 articles (09/2014 - 07/2002)
9.	Ilan, Neta: 10 articles (01/2012 - 05/2004)
10.	Sands, M S: 9 articles (04/2007 - 09/2000)

Related Diseases

1.	Mucopolysaccharidoses 06/01/2003 - "A comprehensive analysis of AAV1-treated brains from beta-glucuronidase-deficient mice (mucopolysaccharidosis type VII) showed complete reversal of pathology in all areas of the brain for at least 1 year, demonstrating that the combination of this serotype and experimental strategy is therapeutically effective for treating global neurometabolic disorders." 10/16/2012 - "We recently reported that PerT-GUS, a form of β-glucuronidase (GUS) chemically modified to eliminate its uptake and clearance by carbohydrate-dependent receptors, crossed the BBB and cleared neuronal storage in an immunotolerant model of murine mucopolysaccharidosis (MPS) type VII. In this respect, the chemically modified enzyme was superior to native β-glucuronidase. " 09/15/1999 - "To better understand the contribution of specific hematopoietic lineages to the efficacy of BMT, we transplanted beta-glucuronidase-positive mononuclear phagocytes derived from either the peritoneum or from bone marrow in vitro into syngeneic recipients with mucopolysaccharidosis type VII (MPS VII). " 05/01/2000 - "Recombinant adenoviruses expressing human beta-glucuronidase (AxCAhGUS) and CTLA-4Ig (AxCACTLA-4Ig) were generated and therapeutic efficacy was investigated using a murine model of mucopolysaccharidosis type VII (MPSVII). " 09/15/1999 - "Behavior and therapeutic efficacy of beta-glucuronidase-positive mononuclear phagocytes in a murine model of mucopolysaccharidosis type VII."
2.	Mucopolysaccharidosis VII (Sly Syndrome) 11/16/2001 - "Biodistribution, kinetics, and efficacy of highly phosphorylated and non-phosphorylated beta-glucuronidase in the murine model of mucopolysaccharidosis VII." 03/01/2003 - "In this study, an adenovirus vector expressing human beta-glucuronidase was injected into mice with mucopolysaccharidosis VII within 24 h of birth, and therapeutic efficacy was evaluated. " 10/01/1998 - "The enzymatic activity of beta-glucuronidase in transduced cells were increased above the control level up to 5 wk. Considering that correction of the enzyme deficiency in a small number of hematopoietic cells can be therapeutic for the Sly disease mouse, our data provide encouragement that human trials of gene therapy based on transferring beta-glucuronidase gene to hematopoietic cells may be efficacious." 06/17/2008 - "Infused Fc-tagged beta-glucuronidase crosses the placenta and produces clearance of storage in utero in mucopolysaccharidosis VII mice." 12/01/1993 - "These studies show that recombinant beta-glucuronidase administered to newborn mice reaches the sites of clinically important storage in murine mucopolysaccharidosis VII."
3.	Neoplasms (Cancer) 02/15/2012 - "The development of near-IR (NIR) probes for imaging of β-glucuronidase activity would be ideal to allow estimation of reporter expression and for personalized glucuronide prodrug cancer therapy in preclinical studies. " 01/01/1996 - "An experimental study of urinary bladder tumor in rats has demonstrated that their development is suppressed and latency period is increased as a result of a prolonged inhibition of a urine enzyme, beta-glucuronidase by treatment with poglucar." 01/01/1969 - "A histochemical study on the distribution and localization of beta-glucuronidase activity in cerebral tumors." 02/01/1967 - "1. Histochemical study of beta-glucuronidase in solid tumors]." 02/01/1966 - "3. Trial of enzymic diagnosis of cancer by beta-glucuronidase isozyme]."
4.	Urinary Bladder Neoplasms (Bladder Cancer) 08/01/1984 - "Additionally, 15 bladder cancer patients judged to be disease free for a median time of 5 years did not have elevated levels of urinary beta-glucuronidase when compared to a normal population of 125 individuals. " 11/01/1972 - "Some statistical and experimental studies on the long term administration of -glucuronidase inhibitor (2,5-di-o-acetyl, D-glucaro(1-4)(6-3) dilactone) to patients of bladder tumor]." 04/01/1969 - "[Study of beta-glucuronidase activity in bladder tumors]." 05/01/1966 - "[Studies on urinary beta-glucuronidase in patients with bladder cancer]." 08/01/1984 - "Thus, the high levels of glucuronidase observed in bladder cancer patients are most likely a consequence of disease rather than a cause."
5.	Wounds and Injuries (Trauma) 02/01/2003 - "To study the wound-responsive expression of CsAAO1 in detail, we examined transgenic tobacco plants harboring a CsAAO1 promoter-beta-glucuronidase fusion gene. " 10/01/1997 - "To study wound-responsive expression of the FAD7 gene in further detail, we analyzed transgenic tobacco plants carrying the -825 Arabidopsis FAD7 promoter-beta-glucuronidase fusion gene. " 03/01/1990 - "Transcriptional fusions between the gene encoding win2 from potato and the reporter gene encoding beta-glucuronidase (GUS) have been used to study the spatial and temporal patterns of wound induced gene activity in transgenic potato and tobacco plants. " 11/01/2010 - "Histochemical observations of Nicotiana benthamiana transformed with 657 bp of the MsPR10.1A promoter fused to the β-glucuronidase (GUS) gene showed that GUS expression was wound-inducible in leaves, which was consistent with MsPR10.1A expression in alfalfa leaves. " 10/01/2006 - "In order to localize cis-regulatory elements involved in the developmental and wound-induced regulation of the At4CL gene family members, At4CL promoter-beta-glucuronidase (GUS) reporter gene fusions were constructed and transferred into Arabidopsis plants. "

Related Drugs and Biologics

1.	Acid Phosphatase
2.	Hexosaminidases (Hexosaminidase)
3.	Muramidase (Lysozyme)
4.	irinotecan (Camptosar)
5.	Enzymes
6.	beta-Galactosidase (Lactaid)
7.	Oxidoreductases
8.	Hydrolases
9.	Prodrugs
10.	Acetylesterase

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Injections
3.	Drug Therapy (Chemotherapy)
4.	Intravenous Injections
5.	Heterologous Transplantation (Xenotransplantation)