AMP-Activated Protein Kinase Kinases

Protein Serine-threonine kinases that phosphorylate the 63-kDa subunit of AMP-ACTIVATED PROTEIN KINASES. This action results in reactivation of AMP-ACTIVATED PROTEIN KINASE activity and downstream signaling aimed at decreased metabolism.

Also Known As:

Networked: 13 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Prabhakar Bhandary, Yashodhar: 1 article (08/2020)
2.	Shaikh, Sadiya Bi: 1 article (08/2020)
3.	Ao, Juan: 1 article (01/2020)
4.	Chen, Deshi: 1 article (01/2020)
5.	Chen, Hu: 1 article (01/2020)
6.	Fei, Junjie: 1 article (01/2020)
7.	Li, Fengtian: 1 article (01/2020)
8.	Luo, Yangkun: 1 article (01/2020)
9.	Luo, Zhijun: 1 article (01/2020)
10.	Niu, Mengmeng: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "Numerous studies have shown that down-regulation of AMPK kinase activity or protein stability not only lead to abnormality of metabolism but also contribute to tumor development. " 08/01/2009 - "An identical mitotic geography of P-AMPKalpha(Thr172) was observed in cancer cells lacking the AMPK kinase LKB1, in non-cancerous human epithelial cells, and in mouse fibroblasts. " 01/01/2020 - "Ablation of AMPKα1 expression or inhibition of AMPK kinase activity leads to disruption of E-cadherin-mediated cell-cell adhesion in vitro and increased tumor metastasis in vivo. "
2.	Hypoxia (Hypoxemia) 01/01/2012 - "The goals of this study were to assess the relative contribution to AMPK activation of phosphorylation by AMPK kinase (AMPKK) and of positive allosterism due to AMP:ATP ratios in the early stages of hypoxia. "
3.	Ischemia 05/31/1996 - "This suggests that following ischemia AMPK is phosphorylated and activated (possibly by an AMPK kinase). " 01/07/2005 - "Although AMPK signaling in the ischemic heart is well characterized, the relative contribution of phosphorylation by AMPK kinase (AMPKK), and positive allosterism by the ratios of AMP:ATP and creatine (Cr):phosphocreatine (PCr), in stimulating AMPK during ischemia are unknown. "
4.	Acute Lung Injury 08/01/2020 - "Effect of curcumin on IL-17A mediated pulmonary AMPK kinase/cyclooxygenase-2 expressions via activation of NFκB in bleomycin-induced acute lung injury in vivo."
5.	Tuberous Sclerosis (Bourneville's Disease) 11/15/2007 - "Furthermore, translation in MDA-MB-231 cells, which lack the AMPK kinase LKB1, and in tuberous sclerosis complex 2 null (TSC2(-/-)) mouse embryonic fibroblasts was unaffected by metformin, indicating that LKB1 and TSC2 are involved in the mechanism of action of metformin. "

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	Adenosine Monophosphate (AMP)
3.	TOR Serine-Threonine Kinases
4.	Cyclooxygenase 2 (Cyclooxygenase-2)
5.	Interleukin-17 (Interleukin 17)
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Cadherins (E-Cadherin)
8.	Uric Acid (Urate)
9.	Protein Kinases (Protein Kinase)
10.	Phosphotransferases (Kinase)