Acute Lung Injury

A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).

Also Known As:

Networked: 5523 relevant articles (388 outcomes, 799 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Adult Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
2.	Lung Injury
3.	Sepsis (Septicemia)
4.	Inflammation
5.	Pulmonary Edema

Experts

1.	Matthay, Michael A: 118 articles (08/2015 - 03/2002)
2.	Ware, Lorraine B: 56 articles (12/2015 - 03/2002)
3.	Traber, Daniel L: 54 articles (12/2013 - 09/2002)
4.	Traber, Lillian D: 45 articles (12/2013 - 09/2002)
5.	Enkhbaatar, Perenlei: 44 articles (12/2013 - 03/2003)
6.	Garcia, Joe G N: 43 articles (12/2015 - 05/2003)
7.	Thompson, B Taylor: 36 articles (10/2015 - 01/2002)
8.	Abraham, Edward: 33 articles (05/2014 - 09/2002)
9.	Gajic, Ognjen: 31 articles (08/2015 - 09/2004)
10.	Schultz, Marcus J: 31 articles (01/2013 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Lung Injury:

1.	Oleic Acid (Oleate)IBA 12/01/2006 - "[The protective effects of intermedin 1-53 on oleic acid induced acute lung injury in rats]." 04/01/2004 - "Changes in liquid clearance of alveolar epithelium after oleic acid-induced acute lung injury in rats." 09/15/2015 - "In this study, we showed that E and/or P administration increased AFC by more than 25% and increased the expression of the α and γ subunits of ENaC by approximately 35% in rats subjected to oleic acid-induced acute lung injury (ALI). " 11/01/2011 - "In this study, we examined the possible role of H(2)S in regulation of the oxidative stress in oleic acid-induced acute lung injury in rats. " 02/01/2011 - "In the present study we observed effects of PTS2 on mouse acute lung injury (ALI) model induced by oleic acid (OA) to analyze the anti-inflammatory activities of PTS2 further. "
2.	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/01/2002 - "Inhalation of nitric oxide (NO) results in selective pulmonary vasodilation, which may be beneficial in the treatment of acute lung injury. " 05/01/2014 - "The advantages and disadvantages of inhaled nitric oxide (iNO) are better recognized today and iNO is not recommended for ARDS and acute lung injury (ALI) in children and adults because iNO results in a transient improvement in oxygenation but does not reduce mortality, and may be harmful. " 02/01/2007 - "Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury." 08/09/2013 - "Rat models of acute lung injury: exhaled nitric oxide as a sensitive, noninvasive real-time biomarker of prognosis and efficacy of intervention." 04/07/2004 - "To evaluate the clinical efficacy of low-dose (5-ppm) inhaled nitric oxide in patients with acute lung injury. "
3.	ONO 5046 (sivelestat)IBA 12/01/2008 - "The present study was designed to examine whether inhibition of NE activity by sivelestat, a specific NE inhibitor with low cellular permeability, is beneficial for acute lung injury induced by Streptococcus pneumoniae in hamsters. " 06/01/2006 - "These results suggest the possibility of conducting prospective clinical trials to assess the efficacy of early sivelestat-Na therapy for aspiration-related acute lung injury." 06/01/2006 - "The efficacy of sivelestat-Na on aspiration-related acute lung injury was analyzed by reviewing case reports published before or after the appearance of the drug on the clinical practice in Japan. " 04/01/2010 - "The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study." 08/01/2008 - "The aim of this study was to evaluate the effect of sivelestat and to determine whether it can reduce lipopolysaccharide (LPS)-induced acute lung injury in rats. "
4.	ParaquatIBA 01/01/2015 - "We hypothesized that SF and OMT combination treatment might have protective effects on paraquat-induced acute lung injury. " 06/01/2012 - "This study investigated the effect of the bark extract of Bathysa cuspidata on paraquat (PQ)-induced extra-pulmonary acute lung injury (ALI) and mortality in rats. " 02/01/2015 - "In conclusion, paraquat can induce IL-1β/IL-18 secretion via NLRP3-ASC-caspase-1 pathway, and the NLRP3 inflammasome is essential for paraquat-induced acute lung injury. " 02/01/2015 - "Acute lung injury was induced by administering paraquat (PQ) intraperitoneally. " 02/01/2015 - "The innate immune response is important in paraquat-induced acute lung injury, but the exact pathways involved are not elucidated. "
5.	Leukocyte Elastase (Neutrophil Elastase)IBA 08/01/2006 - "Several reports have suggested that the earlier neutrophil elastase inhibitor (NEI) is used, the more dramatically the acute lung injury (ALI) following SIRS can be improved. " 03/01/2002 - "Protection against acute lung injury by intravenous or intratracheal pretreatment with EPI-HNE-4, a new potent neutrophil elastase inhibitor." 02/01/2012 - "The objective of this study was to evaluate the effect of neutrophil elastase on the process of tissue repair after acute lung injury in mice. " 08/01/2004 - "Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study." 06/01/2013 - "Neutrophil elastase (NE) takes part in the pathogenesis of acute lung injury. "
6.	CytokinesIBA 04/01/1996 - "By allowing the monitoring of phenotypic and functional parameters, cultures of pulmonary MVEC isolated from ARDS patients may thus represent a useful system to analyze further the mechanisms of acute lung injury and to evaluate the efficacy of drugs, including inhibitors of cytokines and of adhesion molecules." 06/01/2002 - "Therefore, blockade of TF-FVIIa complex protects the lung from injury by LPS in part by reducing local expression of proinflammatory cytokines and may offer promise for therapy of acute lung injury." 09/01/2015 - "Acute lung injury scores, peripheral blood lymphocyte subsets, plasma cytokines, and Foxp3 expression in the spleen were determined. " 05/01/2014 - "Acute lung injury, a frequent complication of intestinal I/R, is an inflammatory disorder of the lung, which is characterized by an overproduction of proinflammatory cytokines and increased permeability of the alveolar-capillary barrier, resulting in multiple organ dysfunction. " 05/01/2014 - "In conclusion, treatment with Del-1-expressed MSCs significantly decreases the severity of endotoxin-induced acute lung injury and the level of inflammatory cytokines in mice."
7.	SodiumIBA 04/01/2009 - "Part of it may be via activating epithelial sodium transport, thus suggesting an important role of alveolar fluid transport in such a model of acute lung injury." 01/01/2001 - "Very recent data suggest that mechanisms that augment transepithelial sodium transport and enhance the clearance of alveolar edema may lead to more effective prevention or treatment for pulmonary edema and acute lung injury." 01/01/2005 - "This study examined the role of NE in PMA-induced acute lung injury in conscious rabbits, using a specific NE inhibitor, sivelestat sodium hydrate (Sivelestat). " 01/01/2012 - "Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor." 12/01/2011 - "The impact of sodium aescinate on acute lung injury induced by oleic acid in rats."
8.	Dexamethasone (Maxidex)FDA LinkGeneric 12/01/2014 - "[A comparison of the protective effects between dexamethasone in overdose and conventional-dose on rat model of acute lung injury]." 01/01/2000 - "To determine whether apoptosis occurs in the lung tissues from rats with acute lung injury (ALI), and observe protective effects of dexamethasone by regulating apoptosis of lung tissues in rats with ALI. " 08/18/2006 - "To study the difference between the preventive and therapeutic effects of dexamethasone on acute lung injury models induced by lipopolysacharide (LPS) in different phases. " 04/01/2006 - "Therefore, this study aimed to investigate whether dexamethasone treatment can attenuate seawater instillation-induced acute lung injury in rabbits. " 02/01/2005 - "The effects of intratracheal dexamethasone on acute lung injury in rabbits--experimental study."
9.	OxygenIBA 11/28/2014 - "P326TAT can be a novel therapeutic agent to treat or prevent acute lung injury in oxygen toxicity." 10/01/2004 - "The 150-kilodalton oxygen-regulated protein ameliorates lipopolysaccharide-induced acute lung injury in mice." 01/01/2010 - "Pharyngeal oxygen administration increases the time to serious desaturation at intubation in acute lung injury: an experimental study." 02/01/2009 - "It is now emerging from these studies that the anatomical localization of NO release, which depends, in part, on whether the oxygen exposure is normobaric or hyperbaric, strongly influences whether toxicity emerges and what form it takes, for example, acute lung injury, central nervous system excitation, or both. " 04/01/2004 - "The purpose of this study was to evaluate the effect of hyperbaric oxygen on acute lung injury induced by intratracheal spraying of lipopolysaccharide (LPS) in rats. "
10.	SmokeIBA 01/01/2013 - "In the present study, we ask whether apple polyphenol provides protection against cigarette smoke (CS)-induced acute lung injury. " 05/01/2006 - "The results of present study show that iNOS may be partially involved in the pathogenesis of acute lung injury induced by smoke inhalation followed by bacterial instillation in the airway." 03/01/2014 - "Identifying inflammatory changes that occur in pulmonary parenchyma earlier than that could provide insight into the pathogenesis of smoke-induced acute lung injury. " 02/01/2014 - "Inhaled anticoagulation regimens are increasingly being used to manage smoke inhalation-associated acute lung injury. " 02/01/2014 - "Inhaled anticoagulation regimens for the treatment of smoke inhalation-associated acute lung injury: a systematic review."

Therapies and Procedures

1.	Liquid Ventilation 03/01/2006 - "Partial liquid ventilation may be beneficial in young patients with acute lung injury or ARDS, although further study is needed to confirm this." 10/01/2009 - "Partial liquid ventilation with various types of perfluorocarbon (PFC) has been shown to be beneficial in treating acute lung injury, a clinical outcome that may involve the anti-inflammatory activity of PFC. " 10/01/2003 - "We sought to know whether there is a further improvement in gas exchange when partial liquid ventilation (PLV) is added to high-frequency oscillatory ventilation (HFOV) in a piglet model of saline lavage-induced acute lung injury. " 01/01/2002 - "Partial liquid ventilation (PLV) with various types of perfluorochemicals (PFC) has been shown to be beneficial in treating acute lung injury. " 01/01/2002 - "Partial liquid ventilation (PLV) with high-specific-weight perfluorocarbon liquids has been shown to improve oxygenation in acute lung injury, possibly by redistributing perfusion from dependent, injured regions to nondependent, less injured regions of the lung. "
2.	Artificial Respiration (Mechanical Ventilation) 04/01/2006 - "In patients with acute lung injury, a diet enriched with EPA + GLA may be beneficial for gas exchange, respiratory dynamics, and requirements for mechanical ventilation." 01/01/2009 - "Better understanding of the pathophysiology of acute lung injury and progress in supportive care and mechanical ventilation have led to slightly improved clinical outcomes. " 01/01/2011 - "Lung protective ventilation (LPV) has been shown to improve survival and the duration of mechanical ventilation in acute lung injury (ALI) patients. " 11/01/2015 - "Effect of statins on the mortality and mechanical ventilation duration of acute lung injury patients: a meta-analysis of five randomized controlled trials." 05/01/2013 - "After acute lung injury with saline lavage, newborn piglets were randomly assigned to 5 study groups (6 in each group): control (no mechanical ventilation), conventional mechanical ventilation for 24 hours, conventional ventilation for 48 hours, HFOV for 24 hours, and HFOV for 48 hours. "
3.	Positive-Pressure Respiration (PEEP) 03/01/2012 - "In the setting of acute lung injury, use of the constant-flow, pressure-volume curve to prescribe PEEP appears associated with improvement in oxygenation with limited risk of acute, process-related, cardiopulmonary deterioration." 01/01/1989 - "Pulmonary clearance of radiotracers after positive end-expiratory pressure or acute lung injury." 09/01/2013 - "Global and regional parameters to visualize the 'best' PEEP during a PEEP trial in a porcine model with and without acute lung injury." 03/01/2013 - "Pressure-volume curves and a recruitment maneuver followed by decremental PEEP trials, with a Vt of 6 and 12 mL/kg, were performed in 24 Wistar rats with acute lung injury induced by intraperitoneally injected (n = 8) or intratracheally instilled (n = 8) Escherichia coli lipopolysaccharide. " 12/01/2012 - "Six piglets with lavage-induced acute lung injury were mechanically ventilated in a decremental PEEP trial that was reduced from 20 to 4 cm H(2)O in steps of 4 cm H(2)O every 10 min. EELV was measured by the modified EELV-N(2) method and computed tomography scan (EELV-CT), volumetric capnography, blood gas measurements, and hemodynamic data were recorded at each PEEP level. "
4.	Mechanical Ventilators (Ventilator) 09/01/2006 - "Several previous investigations have shown improved oxygenation when ventilator-treated patients with acute lung injury are turned prone. " 02/01/2014 - "The use of β2 agonist as an intervention for acute lung injury (ALI) and ARDS patients is controversial, so we performed a systematic review and meta-analysis of the published randomized controlled trials of using β2 agonists to improve outcomes (mortality and ventilator free days) among patients with ALI/ARDS. " 01/01/2012 - "Objective: To determine if dietary supplementation of these substances to patients with acute lung injury would increase ventilator-free days to study day 28. " 10/12/2011 - "To determine if dietary supplementation of these substances to patients with acute lung injury would increase ventilator-free days to study day 28. " 04/01/2011 - "Analysis of plasma biomarker levels and prospectively collected clinical data from patients enrolled in two randomized controlled trials of ventilator therapy for acute lung injury. "
5.	Transplantation (Transplant Recipients) 12/01/2015 - "Bone marrow-derived mesenchymal stem cells (BMSCs) reduced the severity of acute lung injury after transplantation in multiple experimental studies, and several paracrine soluble factors secreted by the cells likely contribute to their therapeutic effect. " 01/01/2014 - "Our previous works demonstrated that systemic orbital fat-derived stem cell (OFSC) transplantation was effective in ameliorating lipopolysaccharide (LPS)-induced extensive acute lung injury (ALI) in vivo mainly through paracrine regulation of macrophage-mediated cytokine-storm. " 12/01/2012 - "Our study has therefore demonstrated the proof-of-concept of using iPS cells for the repair of acute lung injury, demonstrating the potential usefulness of using patient's own iPS cells to prevent immune rejection which arise from allogenic transplantation." 04/01/2012 - "The objective of this study is to investigate the effects and the mechanisms of systemic human orbital fat-derived stem/stromal cell transplantation on lipopolysaccharide-induced acute lung injury. " 10/01/2015 - "When considering the anti-inflammatory, antioxidant, and antiapoptotic properties of iPSCs, the transplantation of iPSCs may represent an effective treatment option for mesenteric I/R-induced acute lung injury."