Telbivudine

A thymidine derivative and antiviral agent that inhibits DNA synthesis by HEPATITIS B VIRUS and is used for the treatment of CHRONIC HEPATITIS B.

Also Known As:

1-(2-Deoxy-beta-L-erythropentafuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione; Telbivudin; Tyzeka; beta-L-2'-Deoxythymidine; beta L 2' Deoxythymidine; 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-L-erythro-pentofuranosyl)-5-methyl-

Networked: 425 relevant articles (83 outcomes, 90 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Lai, Ching-Lung: 12 articles (12/2019 - 09/2004)
2.	Brown, Nathaniel A: 10 articles (02/2009 - 09/2004)
3.	Tang, Hong: 9 articles (09/2021 - 12/2011)
4.	Hou, Jinlin: 9 articles (01/2020 - 02/2008)
5.	Sun, Jian: 9 articles (01/2020 - 02/2011)
6.	Trylesinski, Aldo: 9 articles (03/2016 - 10/2012)
7.	Ren, Hong: 8 articles (01/2020 - 05/2007)
8.	Yuen, Man-Fung: 7 articles (12/2019 - 09/2004)
9.	Jia, Jidong: 7 articles (03/2018 - 02/2008)
10.	Hu, Tsung-Hui: 7 articles (07/2017 - 03/2012)

Related Diseases

1.	Chronic Hepatitis B 06/12/2020 - "To observe the efficacy of telbivudine in chronic hepatitis B (CHB) women with high viral load during pregnancy and the long-term effects on intelligence, growth, and development of the newborns.A total of 87 patients were included. " 12/14/2007 - "Telbivudine: a new treatment for chronic hepatitis B." 11/01/2017 - "Safety and efficacy of telbivudine for chronic hepatitis B during the entire pregnancy: Long-term follow-up." 01/01/2014 - "An observational study to evaluate the safety and efficacy of telbivudine in adults with chronic hepatitis B." 01/01/2009 - "Safety and efficacy of telbivudine for the treatment of chronic hepatitis B."
2.	Infections 09/04/2012 - "Our meta-analysis provides preliminary evidence that telbivudine application in late pregnancy is effective in the interruption of intrauterine HBV infection, with no significant adverse effects or complications. " 02/01/2012 - "Telbivudine treatment has significantly improved the clinical outcome of chronic HBV infection. " 02/01/2009 - "However, concerns about resistance with long-term use, along with inferior cost-effective analyses, have relegated telbivudine to a second-line agent in the management of chronic HBV infection." 09/04/2012 - "A few studies have evaluated the efficacy of telbivudine in preventing intrauterine HBV infection during late pregnancy. " 08/01/2009 - "To investigate the efficacy of telbivudine on intrauterine hepatitis B virus (HBV) infection during the last stage of pregnancy. "
3.	Hepatitis B 05/01/2008 - "Hepatitis B goes globe: Telbivudine as a new treatment option." 10/01/2008 - "A review of telbivudine for the management of chronic hepatitis B virus infection." 12/01/2007 - "Telbivudine for the management of chronic hepatitis B virus infection." 12/01/2011 - "A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infection." 01/01/2023 - "In this retrospective study, serum samples from 39 hepatitis B patients receiving telbivudine were collected and examined for sACE2 concentrations using an ELISA kit.. "
4.	Fibrosis (Cirrhosis) 07/01/2015 - "In conclusion, we showed that telbivudine administration in LT recipients for HBV cirrhosis was effective and it was associated with significant improvement in renal function, but this remains to be confirmed in larger well-designed studies." 04/01/2014 - "Data are limited for comparison of the long-term efficacy of telbivudine (LdT) between hepatitis B virus (HBV)-related compensated and decompensated cirrhosis. " 02/01/2018 - "Telbivudine attenuates UUO-induced renal fibrosis via TGF-β/Smad and NF-κB signaling." 05/01/2017 - "The long-term effects of telbivudine (TBV) on decompensated hepatitis B virus (HBV)-related cirrhosis were still not established. " 03/01/2015 - "We aimed to investigate whether telbivudine could prevent HBV-related fibrosis progression by their influence on CD4(+) T-cell response. "
5.	Liver Failure 02/01/2013 - "This study presents the cases of 2 patients who were chronically infected with HBV and suffered hepatic failure resulting from withdrawal of telbivudine and adefovir, respectively." 11/01/2013 - "Efficacy and safety of telbivudine therapy in liver failure patients with chronic hepatitis B virus infection." 11/01/2013 - "Thus, telbivudine treatment is superior to lamivudine treatment in improving the condition of patients with liver failure as a result of chronic HBV infection in the short term." 11/01/2013 - "The objective of this study was to evaluate the short-term efficacy and safety of telbivudine therapy as compared to lamivudine therapy in liver failure patients with chronic hepatitis B virus (HBV) infection. " 03/01/2018 - "A total of 1660 patients from 12 articles about the efficacy of lamivudine, entecavir, telbivudine and tenofovir for HBV-related liver failure treatment were recruited in the study. "

Related Drugs and Biologics

1.	Lamivudine (Epivir)
2.	entecavir
3.	Hepatitis B e Antigens
4.	Tenofovir (Viread)
5.	adefovir
6.	adefovir dipivoxil (Hepsera)
7.	Antiviral Agents (Antivirals)
8.	lipoarabinomannan (LAM)
9.	DNA (Deoxyribonucleic Acid)
10.	Interferons

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Liver Transplantation
4.	Combination Drug Therapy (Combination Chemotherapy)
5.	Hematopoietic Stem Cell Transplantation